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Frontiers in Cell and Developmental Biology, 2021 During development, sensory hair cells (HCs) in the cochlea assemble a stereociliary hair bundle on their apical surface with planar polarized structure and orientation.
Andre Landin Malt +8 more
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Planar cell polarity and the kidney [PDF]
Nephrology Dialysis Transplantation, 2013 Planar cell polarity (PCP) is the uniform orientation and alignment of a group of cells orthogonal to the apical-basal axis within a tissue. Originally described in insects, it is now known that PCP is required for many processes in vertebrates, including directional cell movement, polarized cell division, ciliary orientation, neural tube closure ...
Papakrivopoulou, E +3 more
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Epidermal growth factor signalling controls Myosin II planar polarity to orchestrate convergent extension movements during Drosophila tubulogenesis [PDF]
, 2014 Aditya Saxena was funded by the Cambridge Commonwealth Trust. Barry Denholm was funded by Kidney Research UK PDF1/2010. Stephanie Bunt was funded by The Rae and Edith Bennett Travelling Scholarship and John Stanley Gardiner Trust Fund.
Krishnaswamy VijayRaghavan +14 more
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The planar polarity pathway [PDF]
Current Biology, 2008 Research in the area of developmental biology has historically focused on the key question of how different cell fates are determined in different regions of the body. From the point of view of producing a functioning organism, however, an equally important question is how cells acquire the appropriate polarities.
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Modelling and Analysis of Planar Cell Polarity [PDF]
Bulletin of Mathematical Biology, 2009 Planar cell polarity (PCP) occurs in the epithelia of many animals and can lead to the alignment of hairs, bristles, and feathers. Here, we present two approaches to modelling this phenomenon. The aim is to discover the basic mechanisms that drive PCP, while keeping the models mathematically tractable.
Schamberg, Sabine +3 more
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CPLANE Complex and Ciliopathies
Biomolecules, 2022 Primary cilia are non-motile organelles associated with the cell cycle, which can be found in most vertebrate cell types. Cilia formation occurs through a process called ciliogenesis, which involves several mechanisms including planar cell polarity (PCP)
Jesús Eduardo Martín-Salazar +1 more
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G3: Genes, Genomes, Genetics, 2017 The Planar cell Polarity Effector (PPE) genes inturned, fuzzy, and fritz are downstream components in the frizzled/starry night signaling pathway, and their function is instructed by upstream Planar Cell Polarity (PCP) core genes such as frizzled and ...
Ying Wang +2 more
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Biology Open, 2015 Hair cells of the organ of Corti (OC) of the cochlea exhibit distinct planar polarity, both at the tissue and cellular level. Planar polarity at tissue level is manifested as uniform orientation of the hair cell stereociliary bundles. Hair cell intrinsic
Anna Kirjavainen +3 more
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Mathematical Modeling of Planar Polarity [PDF]
Developmental Cell, 2005 Although it is well established that the Frizzled receptor is involved in the transmission of polarity information from cell to cell in the Drosophila cuticle, its precise role is still unclear. A recent paper by presents a mathematical model of a feedback loop-based mechanism for propagation of polarity between cells that can account for the known ...
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Cell Polarity and Morphogenesis: Functions and Mechanisms of Cell Divisions in Vertebrate Gastrulation [PDF]
, 2004 Gastrulation shapes a vertebrate embryo from an egg-shaped aggregate of cells. In many vertebrates, massive cell divisions occur during gastrulation. In this thesis, I investigate the pattern, function, and regulation of mitotic divisions in zebrafish ...
Gong, Ying, Ying Gong
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