Results 51 to 60 of about 435,658 (283)
A New Spin on Planar Cell Polarity [PDF]
Cell, 2010 The generation of planar cell polarity (PCP) and tissue shape during morphogenesis is tightly linked, but it is not clear how. Aigouy et al. (2010) now show in the developing Drosophila wing that PCP initially has a radial orientation that becomes realigned to the proximal-distal axis of organ shape by mechanical forces and cell rearrangements mediated
Olguin, Patricio, Mlodzik, Marek
openaire +2 more sources
Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions
iScience, 2020 Summary: Polarized distribution of organelles and molecules inside a cell is vital for a range of cellular processes and its loss is frequently encountered in disease.
Jason Ear +6 more
doaj +1 more source
Journal of Developmental Biology, 2021 The septate junction (SJ) provides an occluding function for epithelial tissues in invertebrate organisms. This ability to seal the paracellular route between cells allows internal tissues to create unique compartments for organ function and endows the ...
Clinton Rice +4 more
doaj +1 more source
Organogenesis, 2011 The clinical burden of both adult and neonatal lung disease worldwide is substantial; in the UK alone, respiratory disease kills one in four people. It is increasingly recognized that genes and pathways that regulate lung development, may be aberrantly activated in disease and/or reactivated as part of the lungs' intrinsic repair mechanisms ...
Yates, LL, Dean, CH
openaire +3 more sources
eLife, 2017 Both oriented cell divisions and cell rearrangements are critical for proper embryogenesis and organogenesis. However, little is known about how these two cellular events are integrated.
Yuwei Li +3 more
doaj +1 more source
Modeling the control of planar cell polarity [PDF]
WIREs Systems Biology and Medicine, 2011 AbstractA growing list of medically important developmental defects and disease mechanisms can be traced to disruption of the planar cell polarity (PCP) pathway. The PCP system polarizes cells in epithelial sheets along an axis orthogonal to their apical–basal axis.
Jeffrey D, Axelrod, Claire J, Tomlin
openaire +2 more sources
Planar Cell Polarity: A Bridge Too Far? [PDF]
, 2008 SummaryThe mechanisms of planar cell polarity are being revealed by genetic analysis. Recent studies have provided new insights into interactions between three proteins involved in planar cell polarity: Flamingo, Frizzled and Van ...
Lawrence, Peter A. +2 more
core +1 more source
A PAR-1-dependent orientation gradient of dynamic microtubules directs posterior cargo transport in the Drosophila oocyte [PDF]
, 2011 Cytoskeletal organization is central to establishing cell polarity in various cellular contexts, including during messenger ribonucleic acid sorting in Drosophila melanogaster oocytes by microtubule (MT)-dependent molecular motors.
Lu, Weiping +26 more
core +1 more source
The morphological dimension of polarity licensing [PDF]
, 2012 Polarity items must, by definition, fit inside the scope of their licenser; items like any N, in addition, appear to require a c-commanding and overt licenser. It is argued that the relevant restriction refers to precedence, not e-command, and that it is
Acquaviva, Paolo
core +1 more source
Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription
FEBS Open Bio, EarlyView.In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang +10 more
wiley +1 more source