Conserved and Divergent Principles of Planar Polarity Revealed by Hair Cell Development and Function [PDF]
Frontiers in Neuroscience, 2021 Planar polarity describes the organization and orientation of polarized cells or cellular structures within the plane of an epithelium. The sensory receptor hair cells of the vertebrate inner ear have been recognized as a preeminent vertebrate model ...
Michael R. Deans, Michael R. Deans
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How do the Fat–Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours? [PDF]
Open Biology, 2021 Planar polarity describes the coordinated polarization of cells within the plane of a tissue. This is controlled by two main pathways in Drosophila: the Frizzled-dependent core planar polarity pathway and the Fat–Dachsous pathway.
Helen Strutt, David Strutt
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Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions [PDF]
iScience, 2020 Summary: Polarized distribution of organelles and molecules inside a cell is vital for a range of cellular processes and its loss is frequently encountered in disease.
Jason Ear +6 more
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Characterisation of cell-scale signalling by the core planar polarity pathway during Drosophila wing development [PDF]
eLifeIn developing epithelia, cells become planar polarised through asymmetric localisation of the core planar polarity proteins to opposite cell membranes, where they form stable intercellular complexes.
Alexandre Carayon +2 more
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Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing [PDF]
Nature CommunicationsPlanar polarity establishment in epithelia requires interpretation of directional tissue-level information at cellular and molecular levels. Mechanical forces exerted during tissue morphogenesis are emerging as crucial tissue-level directional cues, yet ...
Su Ee Tan, David Strutt
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DAnkrd49 and Bdbt act via Casein kinase Iε to regulate planar polarity in Drosophila. [PDF]
PLoS Genetics, 2020 The core planar polarity proteins are essential mediators of tissue morphogenesis, controlling both the polarised production of cellular structures and polarised tissue movements.
Helen Strutt, David Strutt
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Rapid Disruption of Dishevelled Activity Uncovers an Intercellular Role in Maintenance of Prickle in Core Planar Polarity Protein Complexes [PDF]
Cell Reports, 2018 Summary: Planar polarity, the coordinated polarization of cells in the plane of a tissue, is important for normal tissue development and function. Proteins of the core planar polarity pathway become asymmetrically localized at the junctions between cells
Margarida Ressurreição +2 more
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Centriole Translational Planar Polarity in Monociliated Epithelia [PDF]
CellsCiliated epithelia are widespread in animals and play crucial roles in many developmental and physiological processes. Epithelia composed of multi-ciliated cells allow for directional fluid flow in the trachea, oviduct and brain cavities.
Antoine Donati +2 more
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Planar Polarity and Tissue Morphogenesis [PDF]
Cell, 2007 Planar polarity is a global, tissue-level phenomenon that coordinates cell behavior in a two-dimensional plane. The Frizzled/planar cell polarity (PCP) and anterior-posterior (AP) patterning systems for planar polarity operate in a variety of cell types and provide direction to cells with different morphologies and behaviors.
Jennifer A Zallen
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Reciprocal action of Casein Kinase Iε on core planar polarity proteins regulates clustering and asymmetric localisation [PDF]
eLife, 2019 The conserved core planar polarity pathway is essential for coordinating polarised cell behaviours and the formation of polarised structures such as cilia and hairs.
Helen Strutt +2 more
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