Results 1 to 10 of about 5,277,200 (190)
Cell polarity and planar cell polarity (PCP) in spermatogenesis [PDF]
Seminars in Cell and Developmental Biology, 2018 In adult mammalian testes, spermatids, most notably step 17–19 spermatids in stage IV–VIII tubules, are aligned with their heads pointing toward the basement membrane and their tails toward the tubule lumen.
Chris Wong, Haiqi Chen, Lui Wy
exaly +9 more sources
Planar cell polarity (PCP) proteins and spermatogenesis [PDF]
Seminars in Cell and Developmental Biology, 2016 In adult mammalian testes, spermatogenesis is composed of several discrete cellular events that work in tandem to support the transformation and differentiation of diploid spermatogonia to haploid spermatids during the seminiferous epithelial cycle ...
Haiqi Chen, C Yan Cheng
exaly +7 more sources
The PTK7 and ROR2 Protein Receptors Interact in the Vertebrate WNT/Planar Cell Polarity (PCP) Pathway [PDF]
Journal of Biological Chemistry, 2015 Background: The planar cell polarity pathway plays important roles in morphogenetic processes. Results: PTK7 and ROR2 form a heterodimeric complex and bind to WNT5A, promoting JNK phosphorylation and regulating expression of paraxial protocadherin ...
Jean-Paul Borg +2 more
exaly +8 more sources
Frontiers in Cell and Developmental BiologyIntrodution: During development, planes of cells give rise to complex tissues and organs. The proper functioning of these tissues is critically dependent on proper inter- and intra-cellular spatial orientation, a feature known as planar cell polarity ...
Kendra L. Stansak +5 more
doaj +7 more sources
Planar Cell Polarity Signaling: Coordinated Crosstalk for Cell Orientation
Journal of Developmental BiologyThe planar cell polarity (PCP) system is essential for positioning cells in 3D networks to establish the proper morphogenesis, structure, and function of organs during embryonic development.
Sandeep Kacker +7 more
doaj +5 more sources
Biochim Biophys Acta Mol Basis Dis, 2019 Autosomal Recessive Polycystic Kidney Disease (ARPKD) is a genetic disorder with an incidence of ~1:20,000 that manifests in a wide range of renal and liver disease severity in human patients and can lead to perinatal mortality.
Richards T +8 more
europepmc +7 more sources
Autoinhibition of Dishevelled protein regulated by its extreme C terminus plays a distinct role in Wnt/β-catenin and Wnt/planar cell polarity (PCP) signaling pathways. [PDF]
J Biol Chem, 2017 Dishevelled (Dvl) is a key intracellular signaling molecule that mediates the activation of divergent Wnt pathways. It contains three highly conserved domains known as DIX, PDZ, and DEP, the functions of which have been well characterized in β-catenin ...
Qi J +6 more
europepmc +8 more sources
Vangl as a Master Scaffold for Wnt/Planar Cell Polarity Signaling in Development and Disease
Frontiers in Cell and Developmental Biology, 2022 The establishment of polarity within tissues and dynamic cellular morphogenetic events are features common to both developing and adult tissues, and breakdown of these programs is associated with diverse human diseases. Wnt/Planar cell polarity (Wnt/PCP)
Courtney A. Dreyer +2 more
doaj +2 more sources
How do the Fat–Dachsous and core planar polarity pathways act together and independently to coordinate polarized cell behaviours? [PDF]
Open Biology, 2021 Planar polarity describes the coordinated polarization of cells within the plane of a tissue. This is controlled by two main pathways in Drosophila: the Frizzled-dependent core planar polarity pathway and the Fat–Dachsous pathway.
Helen Strutt, David Strutt
doaj +3 more sources
Communications Biology, 2022 The ubiquitin specific protease 39 (USP39) interacts with the transcription factor and cytoplasmic regulator of planar cell polarity (PCP), Grainyheadlike 3 (Grhl3). USP39-dependent PCP gene upregulation contributes to epithelial morphogenesis.
Chiharu Kimura-Yoshida +3 more
doaj +2 more sources