Results 11 to 20 of about 5,277,200 (190)

Deciphering the impacts of modulating the Wnt-planar cell polarity (PCP) pathway on alveolar repair [PDF]

Frontiers in Cell and Developmental Biology
Many adult lung diseases involve dysregulated lung repair. Deciphering the molecular and cellular mechanisms that govern intrinsic lung repair is essential to develop new treatments to repair/regenerate the lungs.
Sally Yunsun Kim, Sek-Shir Cheong, Charlotte Dean   +2 more
exaly   +8 more sources

Planar Cell Polarity Effector Fritz Interacts with Dishevelled and Has Multiple Functions in Regulating PCP

G3: Genes, Genomes, Genetics, 2017
The Planar cell Polarity Effector (PPE) genes inturned, fuzzy, and fritz are downstream components in the frizzled/starry night signaling pathway, and their function is instructed by upstream Planar Cell Polarity (PCP) core genes such as frizzled and ...
Paul Adler, Ying Wang, Víctor Naturale   +2 more
exaly   +5 more sources

SEC14 and Spectrin Domains 1 (Sestd1) and Dapper Antagonist of Catenin 1 (Dact1) Scaffold Proteins Cooperatively Regulate the Van Gogh-like 2 (Vangl2) Four-pass Transmembrane Protein and Planar Cell Polarity (PCP) Pathway during Embryonic Development in Mice [PDF]

Journal of Biological Chemistry, 2013
Background: Dact1 and Vangl2 regulate the planar cell polarity (PCP) pathway during development. Results: Sestd1 genetically and biochemically interacts with Dact1 and Vangl2 and mediates PCP.
Benjamin Cheyette
exaly   +6 more sources

Planar Cell Polarity (PCP) Protein Vangl2 Regulates Ectoplasmic Specialization Dynamics via Its Effects on Actin Microfilaments in the Testes of Male Rats. [PDF]

Endocrinology, 2016
AbstractPlanar cell polarity (PCP) proteins confer polarization of a field of cells (eg, elongating/elongated spermatids) within the plane of an epithelium such as the seminiferous epithelium of the tubule during spermatogenesis. In adult rat testes, Sertoli and germ cells were found to express PCP core proteins (eg, Van Gogh-like 2 [Vangl2 ...
Chen H, Mruk DD, Lee WM, Cheng CY.
europepmc   +6 more sources

The signalling receptor MCAM coordinates apical-basal polarity and planar cell polarity during morphogenesis

Nature Communications, 2017
It is unclear if there is an interaction between apical-basal (AB) polarity and planar cell polarity (PCP) pathways during morphogenesis. Here, the authors define a role for the melanoma cell adhesion molecule (MCAM), known to regulate PCP, in AB ...
Qian Gao, Junfeng Zhang, Xiumei Wang, Ying Liu, Rongqiao He, Xingfeng Liu, Fei Wang, Jing Feng, Dongling Yang, Zhaoqing Wang, Anming Meng, Xiyun Yan   +11 more
doaj   +2 more sources

Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division [PDF]

eLife, 2017
Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g.
Jennifer J Banerjee, Birgit L Aerne, Maxine V Holder, Simon Hauri, Matthias Gstaiger, Nicolas Tapon   +5 more
doaj   +2 more sources

Planar Cell Polarity Controls Pancreatic Beta Cell Differentiation and Glucose Homeostasis [PDF]

Cell Reports, 2012
Planar cell polarity (PCP) refers to the collective orientation of cells within the epithelial plane. We show that progenitor cells forming the ducts of the embryonic pancreas express PCP proteins and exhibit an active PCP pathway.
Cedric Cortijo, Mathieu Gouzi, Fadel Tissir, Anne Grapin-Botton   +3 more
doaj   +2 more sources

Biomechanical regulation of planar cell polarity in endothelial cells

Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2022
Cell polarity refers to the uneven distribution of certain cytoplasmic components in a cell with a spatial order. The planar cell polarity (PCP), the cell aligns perpendicular to the polar plane, in endothelial cells (ECs) has become a research hot spot.
Tao Zhang, Rui Qin, Juhui Qiu
exaly   +2 more sources

SEC14 and Spectrin Domains 1 (Sestd1), Dishevelled 2 (Dvl2) and Dapper Antagonist of Catenin-1 (Dact1) co-regulate the Wnt/Planar Cell Polarity (PCP) pathway during mammalian development [PDF]

Communicative & Integrative Biology, 2013
We previously reported that Sestd1 KO phenocopies Dact1 KO in mice, consistent with a model in which Sestd1 and Dact1 act together to form a crucial functional complex that regulates Vangl2 in the Wnt/Planar Cell Polarity (PCP) pathway.
Xiaoyong Yang, Daniel A. Fisher, B. Cheyette   +2 more
semanticscholar   +5 more sources

Characterisation of cell-scale signalling by the core planar polarity pathway during Drosophila wing development [PDF]

eLife
In developing epithelia, cells become planar polarised through asymmetric localisation of the core planar polarity proteins to opposite cell membranes, where they form stable intercellular complexes.
Alexandre Carayon, Helen Strutt, David Strutt   +2 more
doaj   +2 more sources