Results 1 to 10 of about 3,124 (186)

The Planar Polarity Component VANGL2 Is a Key Regulator of Mechanosignaling [PDF]

Frontiers in Cell and Developmental Biology, 2020
VANGL2 is a component of the planar cell polarity (PCP) pathway, which regulates tissue polarity and patterning. The Vangl2Lp mutation causes lung branching defects due to dysfunctional actomyosin-driven morphogenesis.
Armando del Río Hernández, Mark Griffiths, Sally Yunsun Kim   +2 more
exaly   +6 more sources

The role of VANGL2 in glioma oncogenesis and progression: insights into expression profiles and prognostic relevance [PDF]

Frontiers in Oncology
IntroductionThe Wnt/planar cell polarity (PCP) signaling pathway is pivotal in regulating various biological processes such as early embryonic development, neural crest cell migration, and cancer invasion.
Shanshuang Chen
exaly   +4 more sources

The bidirectional relationship between cilia and PCP signaling pathway core protein Vangl2 [PDF]

Science Progress
Vangl2, a core component of the PCP signaling pathway, serves as a scaffold protein on the cell membrane, playing a crucial role in organizing protein complexes. Cilia, dynamic structures on the cell surface, carry out a wide range of functions. Research
Xin Sheng, Junlin Wu
exaly   +3 more sources

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling. [PDF]

Adv Sci (Weinh)
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Zha F, Feng D, Xue Z, Liu Z, Lin X, Wang Z, Xu L, Chan JFW, Cheung M, Huen MSY, Guo Y, Chan KM, Liu Y, Gao B.   +13 more
europepmc   +2 more sources

Intra-articular delivery of Si-Vangl2 limits cartilage degeneration in an osteoarthritis rat model [PDF]

Frontiers in Bioengineering and Biotechnology
Osteoarthritis (OA) is driven by progressive cartilage degeneration associated with dysregulated chondrocyte metabolism and inflammatory signaling, for which effective disease-modifying treatments remain limited.
Peiru Li, Ke Zhang, Ke Zhang, Zhuoying Li, Yunyang Lu, Hong Zhang   +5 more
doaj   +2 more sources

FGF receptor modulates planar cell polarity in the neuroectoderm via Vangl2 tyrosine phosphorylation [PDF]

Nature Communications
FGF receptors play pivotal roles in morphogenetic processes, including vertebrate neurulation. Planar cell polarity signaling coordinates cell orientation in the tissue plane and is essential for neural tube closure.
Ilya Chuykin, Sergei Y. Sokol
doaj   +2 more sources

Planar cell polarity protein Vangl2 interacts with M-cadherin and stabilizes its cell surface expression in mouse C2C12 myoblasts [PDF]

Frontiers in Cell and Developmental Biology
Skeletal muscle regeneration depends on muscle stem cells (MuSCs), in which cadherin-mediated adhesion and planar cell polarity (PCP) signaling play critical roles.
Tadahiro Nagaoka, Erina Sasaki, Sakiho Takagi, Masashi Kishi, Keisuke Hitachi, Kunihiro Tsuchida   +5 more
doaj   +2 more sources

VANGL2 alleviates inflammatory bowel disease by recruiting the ubiquitin ligase MARCH8 to limit NLRP3 inflammasome activation through OPTN-mediated selective autophagy. [PDF]

PLoS Biology
Inflammatory bowel disease (IBD) is a chronic and potentially life-threatening inflammatory disease of gastroenteric tissue characterized by episodes of intestinal inflammation, but the underlying mechanisms remain elusive.
Huaji Jiang, Yingchao Xie, Zhiqiang Hu, Jiansen Lu, Jiahuan Zhang, Hongyu Li, Ke Zeng, Wenqiang Peng, Cheng Yang, Junsheng Huang, Zelong Han, Xiaochun Bai, Xiao Yu   +12 more
doaj   +2 more sources

CRB2 Facilitates Epithelial Ovarian Cancer Progression by Inducing Polarity Changes via Activation of the Wnt/PCP Signalling Pathway. [PDF]

J Cell Mol Med
ABSTRACT Ovarian cancer exhibits high molecular heterogeneity and metastatic potential, contributing to its status as a leading cause of gynecologic cancer mortality. Cell polarity is essential in tumorigenesis, yet the role of Crumbs family proteins (CRBs), key regulators of apical–basal polarity, in epithelial ovarian cancer (EOC) remains unclear. In
Tao C, Li S, Sun D, Zhou J, Chen Y, Zhang R, Ni X.   +6 more
europepmc   +2 more sources

VANGL2 downregulates HINT1 to inhibit the ATM-p53 pathway and promote cisplatin resistance in small cell lung cancer [PDF]

Cell Death Discovery
Cisplatin is a first-line drug for the treatment of small cell lung cancer (SCLC). Although the majority of patients with SCLC initially respond to cisplatin therapy, cisplatin resistance readily develops, leading to tumor progression.
Jiayi Xie, Huiying Liu, Chunqian Yang, Weitao Shen, Jian Zhang   +4 more
doaj   +2 more sources