Results 31 to 40 of about 3,124 (186)
Scientific Reports, 2023 Although the core constituents of the Wnt/planar cell polarity (PCP) signaling have been extensively studied, their downstream molecules and protein–protein interactions have not yet been fully elucidated.
Tadahiro Nagaoka +4 more
doaj +1 more source
Vangl2 coordinates cell rearrangements during gut elongation [PDF]
Developmental Dynamics, 2019 AbstractBackgroundThe embryonic gut tube undergoes extensive lengthening to generate the surface area required for nutrient absorption across the digestive epithelium. In Xenopus, narrowing and elongation of the tube is driven by radial rearrangements of its core of endoderm cells, a process that concomitantly opens the gut lumen and facilitates ...
Michael K. Dush +1 more
openaire +2 more sources
Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion [PDF]
Cell Reports, 2020 The organization of spatial information, including pattern completion and pattern separation processes, relies on the hippocampal circuits, yet the molecular and cellular mechanisms underlying these two processes are elusive. Here, we find that loss of Vangl2, a core PCP gene, results in opposite effects on pattern completion and pattern separation ...
Robert, Benjamin J.A. +16 more
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PCP Signaling between Migrating Neurons and their Planar-Polarized Neuroepithelial Environment Controls Filopodial Dynamics and Directional Migration. [PDF]
PLoS Genetics, 2016 The planar cell polarity (PCP) pathway is a cell-contact mediated mechanism for transmitting polarity information between neighboring cells. PCP "core components" (Vangl, Fz, Pk, Dsh, and Celsr) are essential for a number of cell migratory events ...
Crystal F Davey +2 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2022 Decline in episodic memory is one of the hallmarks of aging and represents one of the most important health problems facing Western societies. A key structure in episodic memory is the hippocampal formation and the dentate gyrus in particular, as the ...
Muriel Koehl +3 more
doaj +1 more source
Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth
eLife, 2020 Dynamic mechanical interactions between adhesion complexes and the cytoskeleton are essential for axon outgrowth and guidance. Whether planar cell polarity (PCP) proteins, which regulate cytoskeleton dynamics and appear necessary for some axon guidance ...
Steve Dos-Santos Carvalho +9 more
doaj +1 more source
The core planar cell polarity gene, Vangl2, directs adult corneal epithelial cell alignment and migration [PDF]
Royal Society Open Science, 2016 This study shows that the core planar cell polarity (PCP) genes direct the aligned cell migration in the adult corneal epithelium, a stratified squamous epithelium on the outer surface of the vertebrate eye.
Amy S. Findlay +7 more
doaj +1 more source
eLife, 2013 Planar cell polarity (PCP) requires the asymmetric sorting of distinct signaling receptors to distal and proximal surfaces of polarized epithelial cells.
Yusong Guo +2 more
doaj +1 more source
Wtip and Vangl2 are required for mitotic spindle orientation and cloaca morphogenesis [PDF]
Biology Open, 2012 Summary Defects in cilia and basal bodies function are linked to ciliopathies, which result in kidney cyst formation. Recently, cell division defects have been observed in cystic kidneys, but the underlying mechanisms of such defects remain unclear.
Ekaterina Bubenshchikova +8 more
openaire +3 more sources
Nuclear VANGL2 Inhibits Mammary Differentiation [PDF]
, 2022 Mammals are defined by a unique tissue, the mammary glands, which secrete milk that feed their offspring. Even though a milk supply is vital to species’ survival, the molecular mechanisms that regulate lactation remain obscure. Recent research shows that
Rubio, Stefany Alejandrina
core +1 more source