Results 11 to 20 of about 3,124 (186)
Nuclear VANGL2 Inhibits Lactogenic Differentiation [PDF]
Cells, 2023 Planar cell polarity (PCP) proteins coordinate tissue morphogenesis by governing cell patterning and polarity. Asymmetrically localized on the plasma membrane of cells, transmembrane PCP proteins are trafficked by endocytosis, suggesting they may have ...
Natalia Sanz-Gómez +2 more
exaly +10 more sources
Vangl2 Promotes Hematopoietic Stem Cell Expansion [PDF]
Frontiers in Cell and Developmental Biology, 2022 Regulation of hematopoietic stem cell (HSC) self-renewal and differentiation is essential for their maintenance, and HSC polarity has been shown to play an important role in this regulation.
Sarah Bouali +4 more
doaj +5 more sources
Molecular characterisation of endogenous Vangl2/Vangl1 heteromeric protein complexes.
PLoS ONE, 2012 BackgroundMutations in the Planar Cell Polarity (PCP) core gene Vangl2 cause the most severe neural tube defects (NTD) in mice and humans. Genetic studies show that the Vangl2 gene genetically interacts with a close homologue Vangl1. How precisely Vangl2
Edwige Belotti +9 more
doaj +5 more sources
VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland [PDF]
Scientific Reports, 2019 \ua9 2019, The Author(s). The VANGL family of planar cell polarity proteins is implicated in breast cancer however its function in mammary gland biology is unknown. Here, we utilized a panel of Vang1 and Vangl2 mouse alleles to examine the requirement of
Smith P +9 more
core +12 more sources
Investigating the function of VANGL2 in intestinal homeostasis & disease [PDF]
, 2018 INTRODUCTION: Van Gogh-Like 2 (VANGL2) is a scaffolding planar cell polarity protein involved in non-canonical Wnt signalling. It has been shown to have crucial roles in regulating epithelial development and homeostasis.
Mellin, Ronan Peter
core +5 more sources
A vertebrate Vangl2 translational variant required for planar cell polarity
Journal of Biological ChemistryInternational audienceFirst described in the milkweed bug Oncopeltus fasciatus, planar cell polarity (PCP) is a developmental process essential for embryogenesis and development of polarized structures in Metazoans.
Kodjabachian, Laurent +9 more
core +4 more sources
Pathogenesis and potential therapeutic targets of trichorhinophalangeal syndrome; lessons obtained from animal studies. [PDF]
Dev DynAbstract Trichorhinophalangeal syndrome (TRPS) is a rare genetic disease inherited in an autosomal dominant manner. It occurs in 1 in 100,000 people globally and is caused by several types of mutations of the TRPS1 gene. Since the first human patient was reported in 1966, typical and atypical pathologies, disease courses, and treatment case ...
Saeki N +6 more
europepmc +2 more sources
MoleculesKidney failures in infants are mostly caused by congenital anomalies of the kidney and urinary tract (CAKUT), which are among the most common congenital birth disorders worldwide when paired with cardiac abnormalities. People with CAKUT often have severe
Zenon Pogorelić +2 more
exaly +3 more sources
Fold-and-fuse neurulation in zebrafish requires vangl2. [PDF]
Dev Biol, 2023 Abstract Shaping of the future brain and spinal cord during neurulation is an essential component of early vertebrate development. In amniote embryos, primary neurulation occurs through a “fold-and-fuse” mechanism by which the edges of the neural plate fuse into the hollow neural tube.
MacGowan J, Cardenas M, Williams MK.
europepmc +4 more sources
Functional analysis of germline VANGL2 variants using rescue assays of vangl2 knockout zebrafish
Human Molecular Genetics, 2023 Abstract Developmental studies have shown that the evolutionarily conserved Wnt Planar Cell Polarity (PCP) pathway is essential for the development of a diverse range of tissues and organs including the brain, spinal cord, heart and sensory organs, as well as establishment of the left-right body axis.
Derrick, Christopher +20 more
openaire +4 more sources