Results 21 to 30 of about 3,124 (186)

Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development. [PDF]

PLoS ONE, 2012
Experiments utilizing the Looptail mutant mouse, which harbors a missense mutation in the vangl2 gene, have been essential for studies of planar polarity and linking the function of the core planar cell polarity proteins to other developmental signals ...
Haifeng Yin, Catherine O Copley, Lisa V Goodrich, Michael R Deans   +3 more
doaj   +1 more source

Silencing of Vangl2 attenuates the inflammation promoted by Wnt5a via MAPK and NF-κB pathway in chondrocytes

Journal of Orthopaedic Surgery and Research, 2021
Background The Wnt planar cell polarity (PCP) pathway is implicated in osteoarthritis (OA) both in animals and in humans. Van Gogh-like 2 (Vangl2) is a key PCP protein that is required for the orientation and alignment of chondrocytes in the growth plate.
Ke Zhang, Zhuoying Li, Yunyang Lu, Linyi Xiang, Jiadong Sun, Hong Zhang   +5 more
doaj   +1 more source

Vangl2 Regulates E-Cadherin in Epithelial Cells [PDF]

Scientific Reports, 2014
E-cadherin belongs to the classic cadherin subfamily of calcium-dependent cell adhesion molecules and is crucial for the formation and function of epithelial adherens junctions. In this study, we demonstrate that Vangl2, a vertebrate regulator of planar cell polarity (PCP), controls E-cadherin in epithelial cells.
Nagaoka, Tadahiro, Inutsuka, Ayumu, Begum, Khadiza, hafiz, Khandakar musabbir bin, Kishi, Masashi   +4 more
openaire   +2 more sources

PDZ interaction of Vangl2 links PSD-95 and Prickle2 but plays only a limited role in the synaptic localisation of Vangl2 [PDF]

Scientific Reports, 2015
AbstractPostsynaptic density-95/Discs large/Zonula occludens-1 (PDZ) domain-mediated protein interactions play pivotal roles in various molecular biological events, including protein localisation, assembly and signal transduction. Although the vertebrate regulator of planar cell polarity Van Gogh-like 2 (Vangl2) was recently described as a postsynaptic
Tadahiro Nagaoka, Katsuhiko Tabuchi, Masashi Kishi   +2 more
openaire   +2 more sources

Bimodal regulation of Dishevelled function by Vangl2 during morphogenesis [PDF]

Human Molecular Genetics, 2017
Convergent extension (CE) is a fundamental morphogenetic mechanism that underlies numerous processes in vertebrate development, and its disruption can lead to human congenital disorders such as neural tube closure defects. The dynamic, oriented cell intercalation during CE is regulated by a group of core proteins identified originally in flies to ...
Hwa-Seon, Seo, Raymond, Habas, Chenbei, Chang, Jianbo, Wang   +3 more
openaire   +2 more sources

Structural basis of the human Scribble–Vangl2 association in health and disease [PDF]

Biochemical Journal, 2020
Scribble is a critical cell polarity regulator that has been shown to work as either an oncogene or tumor suppressor in a context dependent manner, and also impacts cell migration, tissue architecture and immunity. Mutations in Scribble lead to neural tube defects in mice and humans, which has been attributed to a loss of interaction with the planar ...
Jing Yuan How, Rebecca K. Stephens, Krystle Y.B. Lim, Patrick O. Humbert, Marc Kvansakul   +4 more
openaire   +3 more sources

Vangl2 interaction plays a role in the proteasomal degradation of Prickle2 [PDF]

Scientific Reports, 2019
AbstractThe PET and LIM domain-containing protein, Prickle, plays a key role in planar cell polarity (PCP) in Drosophila. It has been reported that mutations in the PRICKLE2 gene, which encodes one of the human orthologues of Prickle, are associated with human diseases such as epilepsy and autism spectrum disorder. To develop preventive and therapeutic
Tadahiro Nagaoka, Mikio Furuse, Toshihisa Ohtsuka, Kunihiro Tsuchida, Masashi Kishi   +4 more
openaire   +2 more sources

Contribution of VANGL2 mutations to isolated neural tube defects [PDF]

Clinical Genetics, 2010
Vangl2 was identified as the gene defective in the Looptail (Lp) mouse model for neural tube defects (NTDs). This gene forms part of the planar cell polarity (PCP) pathway, also called the non-canonical Frizzled/Dishevelled pathway, which mediates the morphogenetic process of convergent extension essential for proper gastrulation and neural tube ...
Z, Kibar, S, Salem, C M, Bosoi, E, Pauwels, P, De Marco, E, Merello, A G, Bassuk, V, Capra, P, Gros   +8 more
openaire   +2 more sources

Vangl2 regulates the dynamics of Wnt cytonemes in vertebrates [PDF]

, 2020
Abstract The Wnt signalling network regulates cell proliferation and cell differentiation as well as migration and polarity in development of multicellular organisms. However, it is still unclear how distribution of Wnt ligands is precisely controlled to fulfil all of these different functions.
Lucy Brunt, Gediminas Greicius, Benjamin D Evans, David M Virshup, Kyle CA Wedgwood, Steffen Scholpp   +5 more
openaire   +1 more source

The dorsal blastopore lip is a source of signals inducing planar cell polarity in the Xenopus neural plate

Biology Open, 2021
Coordinated polarization of cells in the tissue plane, known as planar cell polarity (PCP), is associated with a signaling pathway critical for the control of morphogenetic processes. Although the segregation of PCP components to opposite cell borders is
Pamela Mancini, Olga Ossipova, Sergei Y. Sokol   +2 more
doaj   +1 more source