Results 41 to 50 of about 3,124 (186)

Planar polarization of Vangl2 in the vertebrate neural plate is controlled by Wnt and Myosin II signaling

Biology Open, 2015
The vertebrate neural tube forms as a result of complex morphogenetic movements, which require the functions of several core planar cell polarity (PCP) proteins, including Vangl2 and Prickle.
Olga Ossipova, Kyeongmi Kim, Sergei Y. Sokol   +2 more
doaj   +1 more source

486 Molecular Mechanisms of Type II Spiral Ganglion Neuron Development

Journal of Clinical and Translational Science, 2023
OBJECTIVES/GOALS: 30,000,000 people in the U.S. have hearing loss, negatively impacting quality of life and work. Understanding auditory axon guidance for spiral ganglia neurons (SGNs) will aid development of new therapies.
Deborah Jane George, Juliet Mejia, Shankar Thiru, Michael Deans, Thomas Coate   +4 more
doaj   +1 more source

Vangl2 disruption alters the biomechanics of late spinal neurulation leading to spina bifida in mouse embryos

Disease Models & Mechanisms, 2018
Human mutations in the planar cell polarity component VANGL2 are associated with the neural tube defect spina bifida. Homozygous Vangl2 mutation in mice prevents initiation of neural tube closure, precluding analysis of its subsequent roles in ...
Gabriel L. Galea, Oleksandr Nychyk, Matteo A. Mole, Dale Moulding, Dawn Savery, Evanthia Nikolopoulou, Deborah J. Henderson, Nicholas D. E. Greene, Andrew J. Copp   +8 more
doaj   +1 more source

Vangl-dependent Wnt/planar cell polarity signaling mediates collective breast carcinoma motility and distant metastasis

Breast Cancer Research, 2023
Background In light of the growing appreciation for the role of collective cell motility in metastasis, a deeper understanding of the underlying signaling pathways will be critical to translating these observations to the treatment of advanced cancers ...
Kacey VanderVorst, Courtney A. Dreyer, Jason Hatakeyama, George R. R. Bell, Julie A. Learn, Anastasia L. Berg, Maria Hernandez, Hyun Lee, Sean R. Collins, Kermit L. Carraway   +9 more
doaj   +1 more source

Gipc1 has a dual role in Vangl2 trafficking and hair bundle integrity in the inner ear [PDF]

, 2012
Vangl2 is one of the central proteins controlling the establishment of planar cell polarity in multiple tissues of different species. Previous studies suggest that the localization of the Vangl2 protein to specific intracellular microdomains is crucial ...
WANG, Lingyan, SANS, Nathalie, EZAN, Jerome, REBOUL, Jerome, RICHARD, Elodie, BRIGANDE, John, MONTCOUQUIOL, Mireille, LASVAUX, Lea, LEMBO, Frederique, KELLEY, Matthew W., BORG, Jean-Paul, GIESE, Arnaud P., MAZZOCCO, Claire   +12 more
core   +1 more source

The Wnt/Planar Cell Polarity Pathway Component Vangl2 Induces Synapse Formation through Direct Control of N-Cadherin

Cell Reports, 2014
Although regulators of the Wnt/planar cell polarity (PCP) pathway are widely expressed in vertebrate nervous systems, their roles at synapses are unknown.
Tadahiro Nagaoka, Riuko Ohashi, Ayumu Inutsuka, Seiko Sakai, Nobuyoshi Fujisawa, Minesuke Yokoyama, Yina H. Huang, Michihiro Igarashi, Masashi Kishi   +8 more
doaj   +1 more source

Exposure to ethanol leads to midfacial hypoplasia in a zebrafish model of FASD via indirect interactions with the Shh pathway

BMC Biology, 2021
Background Gene-environment interactions are likely to underlie most human birth defects. The most common known environmental contributor to birth defects is prenatal alcohol exposure.
Alfire Sidik, Groves Dixon, Desire M. Buckley, Hannah G. Kirby, Shuge Sun, Johann K. Eberhart   +5 more
doaj   +1 more source

Analysis of the Ubiquitination and Phosphorylation of Vangl Proteins

Bio-Protocol, 2022
The core planar cell polarity (PCP) protein Vang/Vangl, including Vangl1 and Vangl2 in vertebrates, is indispensable during development. Our previous studies showed that the activity of Vangl is tightly controlled by two important posttranslational ...
Di Feng, Ziwei He, Bo Gao
doaj   +1 more source

Wnt-induced Vangl2 Phosphorylation Is Dose-Dependently Required for Planar Cell Polarity in Mammalian Development

, 2017
Planar cell polarity (PCP) is an evolutionarily conserved essential mechanism that provides directional information to control and coordinate polarized cellular and tissue behavior during embryonic development.
Liu, X, Choi, NTV, Choi, NT, Garrett, L, Nga Ting Choi, Bo Gao, Yang, Y, Gao, B, Di Feng, Yang, W, Lisa Garrett, Gene Elliott, Elliott, G, Yang , Y, Feng, D, Wei Yang, Xilin Liu, Wang, N, Ni Wang, Wong, YM, Yu Ming Wong, Yingzi Yang, Wang , YM   +22 more
core   +1 more source

Mutant Vangl2 protein alters the distribution wild type Vangl1 and Vangl2.

, 2012
(A–F) The effect of mutant Vangl2 proteins on the distribution of Vangl1 was determined by co-expressing EGFP-Vangl1 in MDCK cells together with 3XHA Vangl2 (A–B), 3XHA Vangl2D255E (C–D) or 3XHA Vangl2S464N (E–F).
Lisa V. Goodrich (182668), Catherine O. Copley (182665), Michael R. Deans (182670), Haifeng Yin (182664)   +3 more
core   +1 more source