Results 61 to 70 of about 3,124 (186)

VANGL2 regulates membrane trafficking of MMP14 to control cell polarity and migration [PDF]

Journal of Cell Science, 2012
Planar cell polarity (PCP) describes the polarized orientation of cells within the plane of a tissue. Unlike epithelial PCP, the mechanisms underlying PCP signaling in migrating cells remain undefined. Here, the establishment of PCP must be coordinated with dynamic changes in cell adhesion and extracellular matrix (ECM) organization.
B Blairanne, Williams, V Ashley, Cantrell, Nathan A, Mundell, Andrea C, Bennett, Rachel E, Quick, Jason R, Jessen   +5 more
openaire   +3 more sources

Functional role of Vangl2 in bile duct injury [PDF]

, 2017
The Liver is comprised of hepatocytes, the parenchymal cells, and non-parenchymal cells which includes stellate cells, portal fibroblasts, inflammatory cells and cholangiocytes.
Wilson, David Hubert Livingstone
core   +3 more sources

Celsr1 adhesive interactions mediate the asymmetric organization of planar polarity complexes

eLife, 2021
To orchestrate collective polarization across tissues, planar cell polarity (PCP) proteins localize asymmetrically to cell junctions, a conserved feature of PCP that requires the atypical cadherin Celsr1. We report that mouse Celsr1 engages in both trans-
Sara N Stahley, Lena P Basta, Rishabh Sharan, Danelle Devenport   +3 more
doaj   +1 more source

Advances in FGF/FGFR Signaling: Implications for Disease and Therapy

MedComm, Volume 7, Issue 9, September 2026.
The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song, Xi Liu, Yang Xiao, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Characterizing Vangl2's Interaction with Celsr1 And Investigating the Function of Neural Tube Defect-Associated Vangl2 Mutants

, 2023
Despite advancements in prenatal care, neural tube defects (NTDs) continue to be one of the most prominent and fatal disorders affecting fetuses. While dietary insufficiencies have been shown to affect proper neural tube closure, it is likely that there ...
Johnson, Ishea
core  

Spatial and temporal analysis of PCP protein dynamics during neural tube closure

eLife, 2018
Planar cell polarity (PCP) controls convergent extension and axis elongation in all vertebrates. Although asymmetric localization of PCP proteins is central to their function, we understand little about PCP protein localization during convergent ...
Mitchell T Butler, John B Wallingford
doaj   +1 more source

Vangl2 promotes the formation of long cytonemes to enable distant Wnt/β-catenin signaling

Nature Communications, 2021
Cytonemes are cellular projections known to transfer Wnt ligands between cells, but their regulation remains unclear. Here, the authors show that activation of the planar cell polarity protein Vangl2 generates long and branched cytonemes increasing ...
Lucy Brunt, Gediminas Greicius, Sally Rogers, Benjamin D. Evans, David M. Virshup, Kyle C. A. Wedgwood, Steffen Scholpp   +6 more
doaj   +1 more source

Multi‐Omics Reveals Early Pregnancy Placental Dysfunction Associated With Preterm and Term Preeclampsia

MedComm, Volume 7, Issue 6, June 2026.
Preeclampsia, a severe pregnancy‐induced disorder unique to humans, affects ∼5% of pregnancies globally. To understand the pathogenesis of preeclampsia, this study performed a comprehensive multi‐omics analysis of early pregnancy placental biopsies (chorionic villus samples) from pregnancies that later developed preterm/term preeclampsia, compared to ...
Ellen Menkhorst, Guannan Yang, Yimiao Yu, Leilani L. Santos, Wei Zhou, Argyro Syngelaki, Swati Varshney, Nicholas A. Williamson, Kaori Koga, Daniel Lorber Rolnik, Fabricio da Silva Costa, Kypros Nicolaides, Kim‐Anh Lê Cao, Evdokia Dimitriadis   +13 more
wiley   +1 more source

The PCP genes Celsr1 and Vangl2 are required for normal lung branching morphogenesis [PDF]

Human Molecular Genetics, 2010
The lungs are generated by branching morphogenesis as a result of reciprocal signalling interactions between the epithelium and mesenchyme during development. Mutations that disrupt formation of either the correct number or shape of epithelial branches affect lung function.
Yates, Laura L., Schnatwinkel, Carsten, Murdoch, Jennifer N., Bogani, Debora, Formstone, Caroline, Townsend, Stuart, Greenfield, Andy, Niswander, Lee A., Dean, Charlotte H.   +8 more
openaire   +3 more sources

The PDZ Protein Na+/H+ Exchanger Regulatory Factor-1 (NHERF1) Regulates Planar Cell Polarity and Motile Cilia Organization. [PDF]

PLoS ONE, 2016
Directional flow of the cerebrospinal fluid requires coordinated movement of the motile cilia of the ependymal epithelium that lines the cerebral ventricles. Here we report that mice lacking the Na+/H+ Exchanger Regulatory Factor 1 (NHERF1/Slc9a3r1, also
Anny Caceres Treat, David S Wheeler, Donna B Stolz, Michael Tsang, Peter A Friedman, Guillermo Romero   +5 more
doaj   +1 more source