Results 81 to 90 of about 3,124 (186)

Model for the NHERF1-induced interaction of Fzd4 and Vangl2.

, 2016
(A) Experimental design of the studies described in Panels (B) and (C). We propose that Fzd4 and Vangl2 interact with the PDZ domains of NHERF1. Thus, in the absence of NHERF1, Fzd4 and Vangl2 are expected to interact only weakly; however, NHERF1 ...
Donna B. Stolz (270230), Anny Caceres Treat (2602243), Michael Tsang (41061), David S. Wheeler (2602240), Peter A. Friedman (753972), Guillermo Romero (2602246)   +5 more
core   +1 more source

Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo [PDF]

Journal of Cell Science, 2013
The planar cell polarity (PCP; non-canonical Wnt) pathway is required to orient the cells within the plane of an epithelium. Here, we show that cofilin 1 (Cfl1), an actin-severing protein, and Vangl2, a core PCP protein, cooperate to control PCP in the early mouse embryo.
James P, Mahaffey, Joaquim, Grego-Bessa, Karel F, Liem, Kathryn V, Anderson   +3 more
openaire   +3 more sources

Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice

Chinese Medical Journal, 2018
Background: Valproic acid (VPA) exposure during pregnancy has been proven to contribute to congenital heart disease (CHD). Our previous findings implied that disruption of planar cell polarity (PCP) signaling pathway in cardiomyocytes might be a factor ...
Hong-Yu Duan, Kai-Yu Zhou, Tao Wang, Yi Zhang, Yi-Fei Li, Yi-Min Hua, Chuan Wang   +6 more
doaj   +1 more source

Cell non-autonomy amplifies disruption of neurulation by mosaic Vangl2 deletion in mice

Nature Communications, 2021
Mutations that cause tissue mosaicism have been identified in individuals with severe congenital defects. Here, the authors show that mosaic deletion of Vangl2 in the murine neuroepithlium causes spina bifida by preventing apical constriction via reduced
Gabriel L. Galea, Eirini Maniou, Timothy J. Edwards, Abigail R. Marshall, Ioakeim Ampartzidis, Nicholas D. E. Greene, Andrew J. Copp   +6 more
doaj   +1 more source

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source

NHERF1 promotes plasma membrane localization of Vangl2.

, 2016
(A) CHO-N10 cells expressing NHERF1 in a tetracycline-sensitive manner were transfected with HA-Fzd1 and EGFP-Vangl2. The cells were treated with 50 nM tetracycline or vehicle, decorated with anti-HA antibody followed by Alexa 594-labeled secondary ...
Donna B. Stolz (270230), Anny Caceres Treat (2602243), Michael Tsang (41061), David S. Wheeler (2602240), Peter A. Friedman (753972), Guillermo Romero (2602246)   +5 more
core   +1 more source

A Meta‐Analysis of the Effects of Chronic Stress on the Prefrontal Transcriptome in Animal Models and Convergence With Existing Human Data

Brain and Behavior, Volume 16, Issue 1, January 2026.
Chronic stress is linked to many human psychiatric disorders involving the prefrontal cortex (PFC). We performed a meta‐analysis of public transcriptional profiling data that showed that chronically stressed mice have less gene expression for glia and neural activity in the PFC. These findings mirror patterns seen in psychiatric patients.
Jinglin Xiong, Megan H. Hagenauer, Cosette A. Rhoads, Elizabeth Flandreau, Nancy Rempel‐Clower, Erin Hernandez, Duy Manh Nguyen, Annaka Saffron, Toni Duan, Stanley Watson Jr., Huda Akil   +10 more
wiley   +1 more source

Interaction of epitope-tagged Vangl2 and Vangl1 proteins.

, 2012
(A) Schematic diagram of Vangl1 and full-length and truncated mutants of Vangl2 used for this study. (B) Transient co-expression of myc-Vangl1 with GFP-Vangl2, GFP-Vangl2ΔN, GFP-Vangl2ΔC, GFP-Vangl2ΔNΔC a control protein (GFP in T47D cells and ...
Emilie Baudelet (130794), Luc Camoin (130796), Jean-Paul Borg (93544), Lea Lasvaux (130802), Mireille Montcouquiol (130807), Michel Pierres (130798), Edwige Belotti (130788), Tania M. Puvirajesinghe (130790), Stéphane Audebert (130792), Géraldine Ferracci (130804)   +9 more
core   +1 more source

Rearrangements between differentiating hair cells coordinate planar polarity and the establishment of mirror symmetry in lateral-line neuromasts

Biology Open, 2012
Summary In addition to their ubiquitous apical-basal polarity, many epithelia are also polarized along an orthogonal axis, a phenomenon termed planar cell polarity (PCP).
Ivana Mirkovic, Serhiy Pylawka, A. J. Hudspeth   +2 more
doaj   +1 more source

Toward Implantation‐Assisting Technologies: Lessons From In Vivo and Ex Vivo Models

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Background Despite advances in assisted reproductive technology (ART), embryo implantation remains inefficient and represents a major barrier to successful pregnancy. Recurrent implantation failure persists even after transfer of high‐quality embryos, reflecting an incomplete understanding of the molecular mechanisms governing implantation ...
Takehiro Hiraoka, Yasushi Hirota, Masahito Ikawa   +2 more
wiley   +1 more source