Results 71 to 80 of about 3,124 (186)

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, Volume 2, Issue 3, Page 280-298, June 2026.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source

Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2

Nature Communications, 2022
Planar cell polarity (PCP) is critical for tissue-wide coordination and successful development. Here Jussila et al. generate a GFP-Vangl2 fusion for live imaging and discover a surprising directionality to the intercellular propagation of cell polarity ...
Maria Jussila, Curtis W. Boswell, Nigel W. Griffiths, Patrick G. Pumputis, Brian Ciruna   +4 more
doaj   +1 more source

Growth‐regulating proteins differ between British seawater fish species, shedding light on their ecological adaptations

Journal of Fish Biology, Volume 108, Issue 6, Page 1701-1711, June 2026.
Abstract Wnt proteins are a family of molecules that help control how cells grow, develop and communicate – processes that are fundamental to the development and health of all animals. Although Wnt pathways have been studied extensively in model species, very little is known about how they operate in marine fish.
Angeliki Maravelia, Soniya Malik, Clare Murcott, Ioannis Batzakas, Paraskevi Goggolidou   +4 more
wiley   +1 more source

Vangl2-regulated polarisation of second heart field-derived cells is required for outflow tract lengthening during cardiac development.

PLoS Genetics, 2014
Planar cell polarity (PCP) is the mechanism by which cells orient themselves in the plane of an epithelium or during directed cell migration, and is regulated by a highly conserved signalling pathway. Mutations in the PCP gene Vangl2, as well as in other
Simon A Ramsbottom, Vipul Sharma, Hong Jun Rhee, Lorraine Eley, Helen M Phillips, Hannah F Rigby, Charlotte Dean, Bill Chaudhry, Deborah J Henderson   +8 more
doaj   +1 more source

Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling

Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian, Mina Ogawa, Manami Kondo, Gabrielle Langeveld, Ling Jun Huan, Feng Zhang, Andrew Hollinger, Sara Deir, Christine Bear, Boyang Zhang, Shinichiro Ogawa   +10 more
wiley   +1 more source

Subcellular localization of Celsr1 and VANGL2 in MDCK II cells.

, 2014
A: The cells were transfected with GFP-Celsr1 or DsRed-VANGL2. GFP-Celsr1 itself was localized to cell membrane while DsRed-VANGL2 was unable to localize to cell membrane. B: The cells were co-transfected with dsRed-VANGL2 (Red) and GFP-Celsr1 wild type,
Yunping Lei (437813), Richard H. Finnell (179831), Wei Yang (109917), M. Elizabeth Ross (437815), Huiping Zhu (294587), Gary M. Shaw (194351)   +5 more
core   +1 more source

The roles of maternal Vangl2 and aPKC inXenopusoocyte and embryo patterning [PDF]

Development, 2011
The Xenopus oocyte contains components of both the planar cell polarity and apical-basal polarity pathways, but their roles are not known. Here, we examine the distribution, interactions and functions of the maternal planar cell polarity core protein Vangl2 and the apical-basal complex component aPKC.
Sang-Wook, Cha, Emmanuel, Tadjuidje, Christopher, Wylie, Janet, Heasman   +3 more
openaire   +2 more sources

Differential sensitivity of midline development to mitosis during and after primitive streak extension

Developmental Dynamics, Volume 255, Issue 5, Page 486-502, May 2026.
Abstract Background Midline establishment is a fundamental process during early embryogenesis for Bilaterians. Midline morphogenesis in non‐amniotes can occur without mitosis, through Planar Cell Polarity (PCP) signaling. By contrast, amniotes utilize both cellular processes for developing the early midline landmark, the primitive streak (PS).
Zhiling Zhao, Rieko Asai, Takashi Mikawa
wiley   +1 more source

Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer [PDF]

Endocrine Related Cancer, 2014
Cancers commonly reactivate embryonic developmental pathways to promote the aggressive behavior of their cells, resulting in metastasis and poor patient outcome. While developmental pathways such as canonical Wnt signaling and epithelial-to-mesenchymal transition have received much attention, our understanding of the role of the planar cell polarity ...
Hatakeyama, Jason, Wald, Jessica H, Printsev, Ignat, Ho, Hsin-Yi Henry, Carraway, Kermit L   +4 more
openaire   +4 more sources

Wnt proteins can direct planar cell polarity in vertebrate ectoderm

eLife, 2016
The coordinated orientation of cells across the tissue plane, known as planar cell polarity (PCP), is manifested by the segregation of core PCP proteins to different sides of the cell.
Chih-Wen Chu, Sergei Y Sokol
doaj   +1 more source