Results 91 to 100 of about 3,124 (186)

Friedelin Ameliorates Nucleus Pulposus Inflammation by Increasing p65 Autophagic Degradation to Inhibit NF‐κB Signalling Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.
ABSTRACT Intervertebral disc degeneration (IVDD) is a prevalent disorder associated with chronic inflammation, significantly affecting spinal health and general quality of life. This study examines the anti‐inflammatory properties of Friedelin (FD) and its impact on the NF‐κB signalling pathway in relation to IVDD.
Kewu Tu, Dongteng Liao, Zhaomou Chen, Zhenyu Wang, Kun Zhao, Hongyu Zhong, Shimin Wu, Huiyin Zhu, Jinming Xu, Beidi Zhou, Xiangheng Dai, Qiang Wu   +11 more
wiley   +1 more source

Brainstem respiratory oscillators develop independently of neuronal migration defects in the Wnt/PCP mouse mutant looptail.

PLoS ONE, 2012
The proper development and maturation of neuronal circuits require precise migration of component neurons from their birthplace (germinal zone) to their final positions.
Muriel Thoby-Brisson, Julien Bouvier, Derrick M Glasco, Michelle E Stewart, Charlotte Dean, Jennifer N Murdoch, Jean Champagnat, Gilles Fortin, Anand Chandrasekhar   +8 more
doaj   +1 more source

Folate Interaction With Genetic Risk for Neural Tube Defects Among Infants in Bangladesh

Birth Defects Research, Volume 117, Issue 12, December 2025.
ABSTRACT Background Neural tube defects such as spina bifida (SB) are congenital anomalies associated with significant morbidity and mortality worldwide. Environmental factors, particularly folate, modify SB risk. Based on recurrence rates of SB within families, genetic risk also contributes to SB development.
Enrique Mondragon‐Estrada, Xingyan Wang, Michael D. Uhler, Afifah Farooque, Kelly Liu, Sudipta Kumer Mukherjee, Sheikh Muhammad Ekramullah, D. M. Arman, Joynul Islam, Hafiza Sultana Suchanda, David C. Christiani, Benjamin C. Warf, Maitreyi Mazumdar, Sarah U. Morton   +13 more
wiley   +1 more source

Heterozygous Vangl2Looptail mice reveal novel roles for the planar cell polarity pathway in adult lung homeostasis and repair

Disease Models & Mechanisms, 2017
Lung diseases impose a huge economic and health burden worldwide. A key aspect of several adult lung diseases, such as idiopathic pulmonary fibrosis (IPF) and chronic obstructive pulmonary disease (COPD), including emphysema, is aberrant tissue repair ...
Thanushiyan Poobalasingam, Laura L. Yates, Simone A. Walker, Miguel Pereira, Nina Y. Gross, Akmol Ali, Maria Kolatsi-Joannou, Marjo-Riitta Jarvelin, Juha Pekkanen, Eugenia Papakrivopoulou, David A. Long, Mark Griffiths, Darcy Wagner, Melanie Königshoff, Matthew Hind, Cosetta Minelli, Clare M. Lloyd, Charlotte H. Dean   +17 more
doaj   +1 more source

Role of Histone Deacetylase and Inhibitors in Cardiovascular Diseases

Cell Proliferation, Volume 58, Issue 12, December 2025.
HDACs play an important role in the occurrence and development of cardiovascular diseases, such as myocardial hypertrophy, hypertension, and atherosclerosis. HDAC inhibitors have broad prospects for the treatment of CVD, and different HDAC subtypes can act through different mechanisms.
Li‐Ying Zhang, Yue‐Yue Wang, Ri Wen, Tie‐Ning Zhang, Ni Yang   +4 more
wiley   +1 more source

Mitotic Spindle Asymmetry: A Wnt/PCP-Regulated Mechanism Generating Asymmetrical Division in Cortical Precursors

Cell Reports, 2014
The regulation of asymmetric cell division (ACD) during corticogenesis is incompletely understood. We document that spindle-size asymmetry (SSA) between the two poles occurs during corticogenesis and parallels ACD.
Delphine Delaunay, Véronique Cortay, Dorothée Patti, Kenneth Knoblauch, Colette Dehay   +4 more
doaj   +1 more source

PCSK9 Loss‐of‐Function Disrupts Cellular Microfilament Network via LIN28A/HES5/JMY Axis in Neural Tube Defects

Advanced Science, Volume 12, Issue 41, November 6, 2025.
PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li, Rui Wang, Wenting Luo, Hui Gu, Tianchu Huang, Qiushi Wang, Zhengwei Yuan   +6 more
wiley   +1 more source

Bioinformatics analysis identifies dysregulation of MiR-548F-3p and its hub gene in triple-negative breast cancer [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Triple-negative breast cancer (TNBC), which affects 15–20% of cases, lacks targeted therapies and poses challenges in treatment. MicroRNAs (miRNAs) are potential biomarkers and therapeutic targets in breast cancer.
Samira Behroozi, Mahdieh Salimi, Najaf Allahyari Fard   +2 more
doaj   +1 more source

List of peptides observed for Vangl2 identification.

, 2012
List of peptides observed for Vangl2 identification.
Emilie Baudelet (130794), Luc Camoin (130796), Jean-Paul Borg (93544), Lea Lasvaux (130802), Mireille Montcouquiol (130807), Michel Pierres (130798), Edwige Belotti (130788), Tania M. Puvirajesinghe (130790), Stéphane Audebert (130792), Géraldine Ferracci (130804)   +9 more
core   +1 more source

The planar cell polarity protein VANGL2 coordinates remodeling of the extracellular matrix

Communicative & Integrative Biology, 2012
Understanding how planar cell polarity (PCP) is established, maintained, and coordinated in migrating cell populations is an important area of research with implications for both embryonic morphogenesis and tumor cell invasion. We recently reported that the PCP protein Vang-like 2 (VANGL2) regulates the endocytosis and cell surface level of membrane ...
Williams, B. Blairanne, Mundell, Nathan, Dunlap, Julie, Jessen, Jason   +3 more
openaire   +2 more sources