Results 51 to 60 of about 3,124 (186)

Differential role of planar cell polarity gene Vangl2 in embryonic and adult mammalian kidneys.

PLoS ONE, 2020
Planar cell polarity (PCP) pathway is crucial for tissue morphogenesis. Mutations in PCP genes cause multi-organ anomalies including dysplastic kidneys.
Ida Derish, Jeremy K H Lee, Melanie Wong-King-Cheong, Sima Babayeva, Jillian Caplan, Vicki Leung, Chloe Shahinian, Michel Gravel, Michael R Deans, Philippe Gros, Elena Torban   +10 more
doaj   +1 more source

Co-Immunoprecipitation assays show oligomeric complex formation consisting of EGFP-Vangl1 and 3XHA-Vangl2, or EGFP-Vangl2 and 3XHA-Vangl2.

, 2012
(A) Immunoprecipitation (IP) of EGFP-Vangl1 or EGFP-Vangl2 using an antibody against GFP pulls down 3XHA-tagged Vangl2 when co-expressed in MDCK cells demonstrating the formation of an oligomeric complex.
Lisa V. Goodrich (182668), Catherine O. Copley (182665), Michael R. Deans (182670), Haifeng Yin (182664)   +3 more
core   +1 more source

Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation

eLife
Van Gogh-like 2 (Vangl2), a core planar cell polarity component, plays an important role in polarized cellular and tissue morphology induction, growth development, and cancer. However, its role in regulating inflammatory responses remains elusive.
Jiansen Lu, Jiahuan Zhang, Huaji Jiang, Zhiqiang Hu, Yufen Zhang, Lian He, Jianwu Yang, Yingchao Xie, Dan Wu, Hongyu Li, Ke Zeng, Peng Tan, Qingyue Xiao, Zijing Song, Chenglong Pan, Xiaochun Bai, Xiao Yu   +16 more
doaj   +1 more source

Betydelsen av VANGL2 i lymfangiogenes

, 2023
The lymphatic system is a network of vessels that permeate a substantial part of the whole body. It plays an essential role in fluid homeostasis by the drainage of interstitial fluid from the blood capillaries, after which the fluid, now called lymph, is
Jakobsson, Emma
core  

VANGL2 en situation de stress hématologique et en cancérologie [PDF]

, 2023
PARTIE I Les voies de signalisation WNT sont essentielles pour plusieurs fonctions des cellules souches hématopoïétiques et progénitrices (HSPC) lors de l’hématopoïèse. Une des voies de signalisation Wnt permet la polarisation planaire des cellules (PCP)
Gauthier, Roxanne A
core   +2 more sources

Loss of Twist1 leads to disruption of ciliary length, endocytic vesicle dynamics, and cell–cell junctions during neural tube formation

Developmental Dynamics, EarlyView.
Abstract Background Endocytosis constitutes a fundamental cellular process governing development through coordinated regulation of plasma membrane remodeling and ciliogenesis, processes essential for cell shape changes and tissue development. Although Twist1 null embryos display complete cranial neural tube (NT) closure defects and conditional knockout
Derrick Thomas, Brittany M. Hufft‐Martinez, Zarna Lalwani, Vi Pham, Mary Elmeniawi, An J. Tran, Jianming Xu, Irfan Saadi, Walid D. Fakhouri   +8 more
wiley   +1 more source

Muscle‐Specific Kinase Signaling and Its Therapeutic Potential

Muscle &Nerve, EarlyView.
ABSTRACT The function of the neuromuscular junction (NMJ) is compromised in many neuromuscular diseases (NMDs) such as autoimmune or congenital myasthenia gravis (MG), amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), and muscular dystrophies.
Stine Marie Jensen, Dana L. E. Vergoossen, Maartje G. Huijbers   +2 more
wiley   +1 more source

Fzd and Vangl2 bind NHERF1.

, 2016
(A) CHO–N10 cells were transfected with HA-Fzd4, and the formation of a Fzd4-NHERF1 complex was determined by coimmunoprecipitation of the HA-tag followed by Western blotting with specific anti-NHERF1 antibodies.
Donna B. Stolz (270230), Anny Caceres Treat (2602243), Michael Tsang (41061), David S. Wheeler (2602240), Peter A. Friedman (753972), Guillermo Romero (2602246)   +5 more
core   +1 more source

Functional analysis of germline VANGL2 variants using rescue assays of vangl2 knockout zebrafish [PDF]

\ua9 The Author(s) 2023. Published by Oxford University Press. Developmental studies have shown that the evolutionarily conserved Wnt Planar Cell Polarity (PCP) pathway is essential for the development of a diverse range of tissues and organs including ...
Chaudhry B, Tohari S, Bouvagnet P, Eley L, Reversade B, Derrick CJ, Alharby E, Coleman AHL, Santos-Ledo A, Szenker-Ravi E, Alqahtani A, Henderson DJ, Yusof A, Roume J, Ng AY-J, Mansard L, Bonnet-Dupeyron M-N, Vache C, Venkatesh B, Roux A-F, Almontashiri NAM   +20 more
core   +4 more sources

Prenatal exome sequencing of fetuses with central nervous system anomalies based on prenatal ultrasound and magnetic resonance imaging diagnosis: A retrospective cohort study with a systematic review and meta‐analysis

Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 10, Page 1950-1964, October 2026.
Prenatal exome sequencing significantly improves diagnostic yield over chromosomal microarray analysis for fetal CNS abnormalities, with a diagnostic yield of 16% in our cohort and 27% in the meta‐analysis. Diagnostic yields vary across different phenotypes. Abstract Introduction Fetal central nervous system (CNS) abnormalities have diverse etiologies,
Jia Yao, Yan Wang, Gang Li, Zhitao Zhang, Yuan Lv, Lizhu Chen   +5 more
wiley   +1 more source