Results 21 to 30 of about 5,277,200 (190)

Directional alignment of different cell types organizes planar cell polarity [PDF]

iScience
Summary: Intercellular coupling between core PCP proteins is essential for unidirectional polarization of epithelial cells, known as planar cell polarity (PCP).
Masaki Arata, Hiroshi Koyama, Toshihiko Fujimori   +2 more
doaj   +2 more sources

Avian Facial Morphogenesis Is Regulated by c-Jun N-terminal Kinase/Planar Cell Polarity (JNK/PCP) Wingless-related (WNT) Signaling* [PDF]

Journal of Biological Chemistry, 2014
Background: Numerous genes contribute to the increased risk of facial clefting, but the cellular mechanisms involved are not well understood. Results: JNK/PCP wingless-related signaling is demonstrated as a major regulator of face shape.
Poongodi Geetha-Loganathan, S. Nimmagadda, Katherine K. Fu, J. Richman   +3 more
semanticscholar   +3 more sources

Coupling Planar Cell Polarity Signaling to Morphogenesis [PDF]

The Scientific World Journal, 2002
Epithelial cells and other groups of cells acquire a polarity orthogonal to their apical–basal axes, referred to as Planar Cell Polarity (PCP). The process by which these cells become polarized requires a signaling pathway using Frizzled as a receptor ...
Jeffrey D. Axelrod, Helen McNeill
doaj   +2 more sources

A systems biology approach to multi-scale modelling and analysis of planar cell polarity in drosophila melanogaster wing [PDF]

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Systems biology aims to describe and understand biology at a global scale where biological systems function as a result of complex mechanisms that happen at
Gao, Qian
core   +7 more sources

Deubiquitination of Vangl by USP6 and USP32 Regulates Planar Cell Polarity Signaling. [PDF]

Adv Sci (Weinh)
Compartment‐specific deubiquitination controls Vangl dosage and planar cell polarity signaling. USP6 and USP32 regulate distinct subcellular pools of Vangl by removing distinct ubiquitin modifications from Vangl proteins. This regulatory mechanism safeguards PCP‐dependent embryonic morphogenesis, while aberrant USP32‐dependent stabilization of VANGL ...
Zha F, Feng D, Xue Z, Liu Z, Lin X, Wang Z, Xu L, Chan JFW, Cheung M, Huen MSY, Guo Y, Chan KM, Liu Y, Gao B.   +13 more
europepmc   +2 more sources

Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway [PDF]

Nature Genetics, 2005
The mammalian auditory sensory organ, the organ of Corti, consists of sensory hair cells with uniformly oriented stereocilia on the apical surfaces and has a distinct planar cell polarity (PCP) parallel to the sensory epithelium. It is not certain how this polarity is achieved during differentiation.
Jianbo Wang, S. Mark, Xiaohui Zhang, Dong Qian, S. Yoo, Kristen Radde‐Gallwitz, Yanping Zhang, Xi Lin, A. Collazo, A. Wynshaw-Boris, P. Chen   +10 more
semanticscholar   +3 more sources

Planar cell polarity in organ formation [PDF]

, 2018
The planar cell polarity (PCP) pathway controls a variety of morphological events across many species. During embryonic development, the PCP pathway regulates coordinated behaviour of groups of cells to direct morphogenetic processes such as convergent ...
Henderson DJ, Long, David A, Long DA, Dean, CH, Dean CH, Henderson, Deborah J, Dean, Charlotte H, Henderson, DJ, Long, DA   +8 more
core   +6 more sources

Activation of Wnt Planar cell polarity (PCP) signaling promotes growth plate column formation in vitro

Journal of Orthopaedic Research, 2012
AbstractDisrupting the Wnt Planar Cell Polarity (PCP) signaling pathway in vivo results in loss of columnar growth plate architecture, but it is unknown whether activation of this pathway in vitro is sufficient to promote column formation. We hypothesized that activation of the Wnt PCP pathway in growth plate chondrocyte cell pellets would promote ...
R. M. Randall, Yvonne Y. Shao, Lai Wang, R. Ballock   +3 more
semanticscholar   +3 more sources

Broadening horizons: Pathogenesis and therapeutics of renal ciliopathies. [PDF]

J Cell Commun Signal
This review elucidates the molecular mechanisms and aberrant signaling pathways in renal ciliopathies, links genetic heterogeneity to clinical phenotypes, and lays a theoretical basis for prenatal diagnosis and novel therapies. Abstract Renal ciliopathies encompass a spectrum of genetic disorders arising from structural or functional impairments of ...
Zhang Q, Xue S, Gao Z, Shi P, Wang L, Feng Q, Kong X, Zhu X.   +7 more
europepmc   +2 more sources

Live imaging and conditional disruption of native PCP activity using endogenously tagged zebrafish sfGFP-Vangl2

Nature Communications, 2022
Planar cell polarity (PCP) is critical for tissue-wide coordination and successful development. Here Jussila et al. generate a GFP-Vangl2 fusion for live imaging and discover a surprising directionality to the intercellular propagation of cell polarity ...
Maria Jussila, Curtis W. Boswell, Nigel W. Griffiths, Patrick G. Pumputis, Brian Ciruna   +4 more
doaj   +1 more source