Epidermal growth factor signalling controls Myosin II planar polarity to orchestrate convergent extension movements during Drosophila tubulogenesis [PDF]
, 2014 Aditya Saxena was funded by the Cambridge Commonwealth Trust. Barry Denholm was funded by Kidney Research UK PDF1/2010. Stephanie Bunt was funded by The Rae and Edith Bennett Travelling Scholarship and John Stanley Gardiner Trust Fund.
Krishnaswamy VijayRaghavan +14 more
core +1 more source
Symmetry Breaking in an Edgeless Epithelium by Fat2-Regulated Microtubule Polarity
Cell Reports, 2016 Planar cell polarity (PCP) information is a critical determinant of organ morphogenesis. While PCP in bounded epithelial sheets is increasingly well understood, how PCP is organized in tubular and acinar tissues is not. Drosophila egg chambers (follicles)
Dong-Yuan Chen +4 more
doaj +1 more source
Celsr1 and Celsr2 exhibit distinct adhesive interactions and contributions to planar cell polarity
Frontiers in Cell and Developmental Biology, 2023 Cadherin EGF LAG seven-pass G-type receptor (Celsr) proteins 1-3 comprise a subgroup of adhesion GPCRs whose functions range from planar cell polarity (PCP) signaling to axon pathfinding and ciliogenesis. Like its Drosophila ortholog, Flamingo, mammalian
L. Basta +5 more
semanticscholar +1 more source
Cell Polarity and Morphogenesis: Functions and Mechanisms of Cell Divisions in Vertebrate Gastrulation [PDF]
, 2004 Gastrulation shapes a vertebrate embryo from an egg-shaped aggregate of cells. In many vertebrates, massive cell divisions occur during gastrulation. In this thesis, I investigate the pattern, function, and regulation of mitotic divisions in zebrafish ...
Gong, Ying, Ying Gong
core +1 more source
Investigating the Role of the Planar Cell Polarity (PCP) Protein CELSR1 in Breast Cancer
, 2023 Planar cell polarity (PCP) is essential for generating highly organized tissue structures and for directional cell movement/migration. The role of PCP in embryogenesis is well-documented, however its role in adult pathologies, such as cancer, is a relatively new field of research.
openaire +4 more sources
Van Gogh and Frizzled act redundantly in the Drosophila sensory organ precursor cell to orient its asymmetric division. [PDF]
PLoS ONE, 2009 Drosophila sensory organ precursor cells (SOPs) divide asymmetrically along the anterior-posterior (a-p) body axis to generate two different daughter cells. Planar Cell Polarity (PCP) regulates the a-p orientation of the SOP division. The localization of
José-Eduardo Gomes +2 more
doaj +1 more source
Breast Cancer Research, 2023 Background In light of the growing appreciation for the role of collective cell motility in metastasis, a deeper understanding of the underlying signaling pathways will be critical to translating these observations to the treatment of advanced cancers ...
K. Vandervorst +9 more
semanticscholar +1 more source
The distribution of Dishevelled in convergently extending mesoderm [PDF]
, 2013 Convergent extension (CE) is a conserved morphogenetic movement that drives axial lengthening of the primary body axis and depends on the planar cell polarity (PCP) pathway.
Panousopoulou, Eleni +7 more
core +1 more source
Cancer Letters, 2023 Targeting common oncogenic drivers of glioblastoma multiforme (GBM) in patients has remained largely ineffective, raising the possibility that alternative pathways may contribute to tumor aggressiveness.
C. Dreyer +8 more
semanticscholar +1 more source
Wnt, Hedgehog and junctional Armadillo/beta-catenin establish planar polarity in the Drosophila embryo. [PDF]
PLoS ONE, 2006 To generate specialized structures, cells must obtain positional and directional information. In multi-cellular organisms, cells use the non-canonical Wnt or planar cell polarity (PCP) signaling pathway to establish directionality within a cell.
Pamela F Colosimo, Nicholas S Tolwinski
doaj +1 more source