Results 51 to 60 of about 5,277,200 (190)
Journal of Clinical Medicine, 2023 Background: Treatment and outcomes of breast cancer, one of the most prevalent female cancers, have improved in recent decades. However, metastatic breast cancer remains incurable in most cases, and new therapies are needed to ameliorate prognosis ...
I. Voutsadakis
semanticscholar +1 more source
PCP and Wnt pathway components act in parallel during zebrafish mechanosensory hair cell orientation
Nature Communications, 2019 Planar cell polarity (PCP) regulates hair cell orientation in the zebrafish lateral line. Here, the authors show that mutating Wnt pathway genes (wnt11f1, fzd7a/b, and gpc4) causes concentric hair cell patterns not regulated by PCP, thus showing PCP/Wnt ...
Joaquin Navajas Acedo +7 more
doaj +1 more source
Developmental Dynamics, 2023 The local signaling mechanism which directly assembles and maintains glutamatergic synapses has not been well understood. Glutamatergic synapses are made of presynaptic and postsynaptic compartments with distinct sets of proteins.
Andiara E. Freitas +3 more
semanticscholar +1 more source
Cell autonomous polarization by the planar cell polarity signaling pathway
bioRxiv, 2023 As epithelial cells polarize in the tissue plane, the Planar Cell Polarity (PCP) signaling module segregates two distinct molecular subcomplexes to opposite sides of cells.
Alexis T. Weiner +5 more
semanticscholar +1 more source
Cell Reports, 2018 Summary: Planar polarity, the coordinated polarization of cells in the plane of a tissue, is important for normal tissue development and function. Proteins of the core planar polarity pathway become asymmetrically localized at the junctions between cells
Margarida Ressurreição +2 more
doaj +1 more source
Structural and Functional Siderophore Remodeling by Enzymatic Delipidation
Angewandte Chemie, Volume 138, Issue 39, 21 September 2026.A surprising functional switch in bacterial siderophores was discovered through genome mining and the analysis of environmental and pathogenic Pandoraea species. Pandorachelin B, a lipocyclopeptide that promotes swarming motility, is cleaved by a specialized acylase, yielding a ring‐contracted, homodetic cyclopeptide, pandorachelin A, which exhibits ...
Elena Herzog +5 more
wiley +2 more sources
Requirement for Dlgh-1 in planar cell polarity and skeletogenesis during vertebrate development. [PDF]
PLoS ONE, 2013 The development of specialized organs is tightly linked to the regulation of cell growth, orientation, migration and adhesion during embryogenesis. In addition, the directed movements of cells and their orientation within the plane of a tissue, termed ...
Charlene Rivera +7 more
doaj +1 more source
Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity [PDF]
, 2011 Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components ...
Isabelle Roszko +5 more
core +1 more source
Wnt-Frizzled planar cell polarity signaling in the regulation of cell motility
Current Topics in Developmental Biology, 2022 The molecular complexes underlying planar cell polarity (PCP) were first identified in Drosophila through analysis of mutant phenotypes in the adult cuticle and the orientation of associated polarized protrusions such as wing hairs and sensory bristles ...
Yildiz Koca +2 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2022 Planar cell polarity (PCP) signaling polarizes cells within the plane of an epithelium. In the airways, planar cell polarity signaling orients the directional beating of motile cilia required for effective mucociliary clearance.
Koshi Kunimoto +4 more
doaj +1 more source