Results 71 to 80 of about 5,277,200 (190)

Triggered Calcium Lightning Programs Cochlear Development

Exploration, EarlyView.
Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma, Hai‐Peng Wang, Yu‐Meng Jiang, Ke Lai, Ming‐Xian Li, Zhen Zhang, Li‐Na Gong, Jing‐Wei Lai, Kai‐Ming Su, Lu‐Yang Wang, Hui Wang, Shan‐Kai Yin, Hao He, Hai‐Bo Shi   +13 more
wiley   +1 more source

Flexible photocatalytic materials: From substrate engineering to multi‐field synergistic enhancement

FlexMat, EarlyView.
This review examines flexible photocatalytic systems, covering substrate evolution from polymers to biomass, fabrication methods like electrospinning, and key mechanical and optoelectrochemical metrics under deformation. Enhancement strategies are critically discussed, followed by applications in energy conversion, environmental remediation, and ...
Weiqi Wang, Xinrong Zhang, Jing Zhao, Songcan Wang   +3 more
wiley   +1 more source

The Meckel-Gruber syndrome protein TMEM67 controls basal body positioning and epithelial branching morphogenesis in mice via the non-canonical Wnt pathway. [PDF]

, 2015
Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes.
Daniel J. Jagger, Zakia A. Abdelhamed, Johnson, CA, Carmel Toomes, Jagger, DJ, Johnson, Colin A., Toomes, C, Wheway, G, Christopher F. Inglehearn, Colin A. Johnson, Jagger, Daniel J., Toomes, Carmel, Abdelhamed, ZA, Abdelhamed, Zakia A., Subaashini Natarajan, Inglehearn, CF, Natarajan, Subaashini, Gabrielle Wheway, Inglehearn, Christopher F., Natarajan, S, Inglehearn, Chris F., Wheway, Gabrielle   +21 more
core   +1 more source

Tissue flow regulates planar cell polarity independently of the Frizzled core pathway.

Cell Reports, 2022
Planar cell polarity (PCP) regulates the orientation of external structures. A core group of proteins that includes Frizzled forms the heart of the PCP regulatory system. Other PCP mechanisms that are independent of the core group likely exist, but their
T. Ayukawa, Masakazu Akiyama, Y. Hozumi, K. Ishimoto, J. Sasaki, Senoo Haruki, T. Sasaki, M. Yamazaki   +7 more
semanticscholar   +1 more source

Survey on differential estimators for 3d point clouds

Computer Graphics Forum, EarlyView.
Abstract Recent advancements in 3D scanning technologies, including LiDAR and photogrammetry, have enabled the precise digital replication of real‐world objects. These methods are widely used in fields such as GIS, robotics, and cultural heritage. However, the point clouds generated by such scans are often noisy and unstructured, posing challenges for ...
Léo Arnal–Anger, Thibault Lejemble, David Coeurjolly, Loïc Barthe, Nicolas Mellado   +4 more
wiley   +1 more source

Loss of CFTR Function Increases Wnt/Planar Cell Polarity (PCP) Signaling and Tight Junction Permeability in Intestinal Epithelium

The FASEB Journal, 2019
Cystic fibrosis (CF) patients and cystic fibrosis transmembrane conductance regulator (Cftr) knockout (KO) mice exhibit increased intestinal paracellular permeability. This can lead to the translocation of bacterial toxins from the gut lumen into the circulation, adversely affecting liver and lung function.
Rowena Woode, Nancy Walker, Jinghua Liu, Ashlee Strubberg, Lane Clarke   +4 more
openaire   +1 more source

Frizzled-Induced Van Gogh Phosphorylation by CK1ε Promotes Asymmetric Localization of Core PCP Factors in Drosophila

Cell Reports, 2016
Epithelial tissues are polarized along two axes. In addition to apical-basal polarity, they are often polarized within the plane of the epithelium, so-called Planar Cell Polarity (PCP).
Lindsay K. Kelly, Jun Wu, Wang A. Yanfeng, Marek Mlodzik   +3 more
doaj   +1 more source

Planar cell polarity and the pathogenesis of Tourette Disorder: New hypotheses and perspectives.

Developmental Biology, 2022
Planar cell polarity (PCP) signaling plays a fundamental role in shaping the development and ongoing function of the nervous system, beginning from early stages of neural tube closure and spanning the maintenance of functional synapses in adults.
Jun-Bing Wu, Lauren A Poppi, Max A. Tischfield   +2 more
semanticscholar   +1 more source

Wt1 Is Required for the Regression of Müllerian Ducts in Male Mice by Inducing Wif1 and Osx Expression

Cell Proliferation, EarlyView.
Wt1 expressed in the MD mesenchyme promotes MD regression by inducing Wif1 and Osx transcription. In male mice, mesenchyme‐specific inactivation of Wt1 results in MD retention. ABSTRACT In mammals, Müllerian ducts (MDs) are the precursors of the female reproductive tract which regress in males during embryonic development.
Min Chen, Xin Qi, Shanshan Qin, Jia Kang, Changhuo Cen, Miao Guo, Yang Gao, Mengyue Wang, Jiayi Li, Xiuhong Cui, Yanbo Wang, Lan Zhu, Fei Gao   +12 more
wiley   +1 more source

The cell biology of planar cell polarity

, 2014
Planar cell polarity (PCP) refers to the coordinated alignment of cell polarity across the tissue plane. Key to the establishment of PCP is asymmetric partitioning of cortical PCP components and intercellular communication to coordinate polarity between ...
Devenport, Danelle, Danelle Devenport
core   +1 more source