Results 91 to 100 of about 5,277,200 (190)

Prickle isoforms determine handedness of helical morphogenesis

eLife, 2020
Subcellular asymmetry directed by the planar cell polarity (PCP) signaling pathway orients numerous morphogenetic events in both invertebrates and vertebrates.
Bomsoo Cho, Song Song, Jeffrey D Axelrod
doaj   +1 more source

Prickle1 regulates neurite outgrowth of apical spiral ganglion neurons but not hair cell polarity in the murine cochlea. [PDF]

PLoS ONE, 2017
In the mammalian organ of Corti (OC), the stereocilia on the apical surface of hair cells (HCs) are uniformly organized in a neural to abneural axis (or medial-laterally). This organization is regulated by planar cell polarity (PCP) signaling.
Tian Yang, Jennifer Kersigo, Shu Wu, Bernd Fritzsch, Alexander G Bassuk   +4 more
doaj   +1 more source

Lung Pericytes: Molecular Mechanisms, Signaling Pathways, and Roles in Pulmonary Diseases

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Central role of pericytes across major pulmonary diseases. Conceptual wheel diagram illustrating the central role of lung pericytes across diverse pulmonary disease states. A pericyte positioned at the center expresses canonical markers, including PDGFRβ, CD146, and NG2, and connects radially to five major disease contexts.
Stuti Agarwal, Anuradha Bankar, Vinicio A. de Jesus Perez   +2 more
wiley   +1 more source

Coordination of planar cell polarity pathways through Spiny-legs

eLife, 2015
Morphogenesis and physiology of tissues and organs requires planar cell polarity (PCP) systems that orient and coordinate cells and their behaviors, but the relationship between PCP systems has been controversial.
Abhijit A Ambegaonkar, Kenneth D Irvine
doaj   +1 more source

Cryo-EM structure and oligomerization of the human planar cell polarity core protein Vangl1

Nature Communications
Vangl is a planar cell polarity (PCP) core protein essential for aligned cell orientation along the epithelial plane perpendicular to the apical-basal direction, which is important for tissue morphogenesis, development and collective cell behavior ...
Fan Zhang, Shao-Bai Li, Hao Wu, Shanshuang Chen   +3 more
semanticscholar   +1 more source

Impacts of Ionospheric Conductance During the December 2021 Solar Eclipse on the Coupled Magnetosphere‐Ionosphere‐Thermosphere System

Journal of Geophysical Research: Space Physics, Volume 131, Issue 8, August 2026.
Abstract Solar eclipses provide unique opportunities to investigate geospace dynamics driven by rapid, localized reductions in solar radiation. On December 4th $4\text{t}\text{h}$, 2021, a total solar eclipse occurred over West Antarctica during substorms.
Yu Hong, Yue Deng, Daniel T. Welling, Aaron J. Ridley, Gang Lu, Astrid Maute, Qingyu Zhu, Sebastijan Mrak, Colin Waters, Cheng Sheng, Minjing Li, Ramon Lopez   +11 more
wiley   +1 more source

Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton.

PLoS Biology, 2013
Planar cell polarity (PCP) regulates cell alignment required for collective cell movement during embryonic development. This requires PCP/PCP effector proteins, some of which also play essential roles in ciliogenesis, highlighting the long-standing ...
Cheng Cui, Bishwanath Chatterjee, Thomas P Lozito, Zhen Zhang, Richard J Francis, Hisato Yagi, Lisa M Swanhart, Subramaniam Sanker, Deanne Francis, Qing Yu, Jovenal T San Agustin, Chandrakala Puligilla, Tania Chatterjee, Terry Tansey, Xiaoqin Liu, Matthew W Kelley, Elias T Spiliotis, Adam V Kwiatkowski, Rocky Tuan, Gregory J Pazour, Neil A Hukriede, Cecilia W Lo   +21 more
doaj   +1 more source

Contrast Agents for Enhanced Bioimaging: A Comprehensive Review

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
Contrast agents, especially those that are nanoparticle‐based, are revolutionizing bioimaging by enabling highly sensitive, specific, and early‐stage diagnosis of diseases like cancer, using clinical imaging modalities such as CT, MRI, PET, and SPECT.
Paulo Sérgio Taube, Donald Fernandes, Arthur Abinader Vasconcelos, Hugo de Campos Braga, Alan Kelbis Oliveira Lima, José Arnaldo Santana Costa, Karla Furtado Andriani, Ester da Cunha Meira Santos, Antonio Jorge Silva Araújo Junior, Hauster Maximiler Campos de Paula, Wallace Júnio Reis, Kashif Gul, Nida Wahab, Luis Carlos Resio, Elisa Kawana Leal dos Santos, Márcio Peres de Araujo, Matheus Allen P. da Silva, Juliana Paula da Silva   +17 more
wiley   +1 more source

The planar cell polarity pathway in vertebrate development

, 2011
Directing the orientation of cells in three dimensions is a fundamental aspect of many of the processes underlying the generation of the appropriate shape and function of tissues and organs during embryonic development.
Meijlink, F., Wansleeben, C.
core   +1 more source

Cell polarity, cell adhesion, and spermatogenesis: role of cytoskeletons [version 1; referees: 2 approved]

F1000Research, 2017
In the rat testis, studies have shown that cell polarity, in particular spermatid polarity, to support spermatogenesis is conferred by the coordinated efforts of the Par-, Crumbs-, and Scribble-based polarity complexes in the seminiferous epithelium ...
Linxi Li, Ying Gao, Haiqi Chen, Tito Jesus, Elizabeth Tang, Nan Li, Qingquan Lian, Ren-shan Ge, C. Yan Cheng   +8 more
doaj   +1 more source