Results 1 to 10 of about 62,967 (236)
eLife, 2021 Metastasis is responsible for approximately 90% of cancer-associated mortality but few models exist that allow for rapid and effective screening of anti-metastasis drugs.
Joji Nakayama +6 more
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Molecular anatomy of the pre-primitive-streak chick embryo [PDF]
Open Biology, 2020 The early stages of development of the chick embryo, leading to primitive streak formation (the start of gastrulation), have received renewed attention recently, especially for studies of the mechanisms of large-scale cell movements and those that ...
Hyung Chul Lee +6 more
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A single-cell molecular map of mouse gastrulation and early organogenesis
Nature, 2019 Across the animal kingdom, gastrulation represents a key developmental event during which embryonic pluripotent cells diversify into lineage-specific precursors that will generate the adult organism. Here we report the transcriptional profiles of 116,312
Blanca Pijuan-Sala +15 more
semanticscholar +1 more source
Ptenb mediates gastrulation cell movements via Cdc42/AKT1 in zebrafish.
PLoS ONE, 2011 Phosphatidylinositol 3-kinase (PI3 kinase) mediates gastrulation cell migration in zebrafish via its regulation of PIP(2)/PIP(3) balance. Although PI3 kinase counter enzyme PTEN has also been reported to be essential for gastrulation, its role in ...
Chen-Min Yeh +5 more
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eLife, 2022 The morphogenic process of convergent thickening (CT) was originally described as the mediolateral convergence and radial thickening of the explanted ventral involuting marginal zone (IMZ) of Xenopus gastrulae (Keller and Danilchik, 1988).
David R Shook +9 more
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A mechanochemical model recapitulates distinct vertebrate gastrulation modes
bioRxiv, 2021 Gastrulation is a critical event in vertebrate morphogenesis driven by cellular processes, and characterized by coordinated multi-cellular movements that form the robust morphological structures.
M. Serra +7 more
semanticscholar +1 more source
Rab7 is required for mesoderm patterning and gastrulation in Xenopus
Biology Open, 2021 Early embryogenesis requires tightly controlled temporal and spatial coordination of cellular behavior and signaling. Modulations are achieved at multiple levels, from cellular transcription to tissue-scale behavior.
Jennifer Kreis +2 more
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Quo vadis PGRMC? Grand-Scale Biology in Human Health and Disease
Frontiers in Bioscience-Landmark, 2022 The title usage of Latin Quo vadis ‘where are you going’ extends the question Unde venisti from where ‘did you come?’ posed in the accompanying paper and extends consideration of how ancient eukaryotic and eumetazoan functions of progesterone receptor ...
Michael A. Cahill
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Imaging in Spinal DysraphismA Pictoral Assay [PDF]
International Journal of Anatomy Radiology and Surgery, 2021 Spinal dysraphism includes the congenital malformations of the spine and spinal cord. Spinal cord development takes place through successive stages of gastrulation, primary neurulation, and secondary neurulation. Defect in any of these three phases can
Anurudh Kishore Vatti +2 more
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eLife, 2018 In vivo, the primary molecular mechanotransductive events mechanically initiating cell differentiation remain unknown. Here we find the molecular stretching of the highly conserved Y654-β-catenin-D665-E-cadherin binding site as mechanically induced by ...
Jens-Christian Röper +8 more
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