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From genes to germ layers: virtual twins of gastruloids [PDF]

npj Systems Biology and Applications
Human gastrulation remains a black box due to ethical and technical reasons. Human pluripotent stem cell-based 2D micropatterns and 3D organoids (gastruloids) recapitulate aspects of human gastrulation.
Leona M. Irwin, Shaun M. Cowley, Himanshu Kaul   +2 more
doaj   +2 more sources

Extracellular presentation of syntaxin4 as a potential trigger for region-specific gastrulation [PDF]

Cell Structure and Function
During early embryogenesis, gastrulation occurs within a specific region of the pluripotent epiblast, where cells undergo significant changes in their context.
Sae Nozaki, Taisei Mihara, Yohei Hirai
doaj   +2 more sources

Reassembling gastrulation

Developmental Biology, 2021
During development, a single cell is transformed into a highly complex organism through progressive cell division, specification and rearrangement. An important prerequisite for the emergence of patterns within the developing organism is to establish asymmetries at various scales, ranging from individual cells to the entire embryo, eventually giving ...
Alexandra Schauer, Carl-Philipp Heisenberg   +1 more
openaire   +2 more sources

Fishing for drugs

eLife, 2022
Screening for drugs that disrupt embryonic development in zebrafish can help identify treatments that suppress metastasis.
Chinyere Kemet, Emily Hill, Hui Feng
doaj   +1 more source

Genetically programmed retinoic acid deficiency during gastrulation phenocopies most known developmental defects due to acute prenatal alcohol exposure in FASD

Frontiers in Cell and Developmental Biology, 2023
Fetal Alcohol Spectrum Disorder (FASD) arises from maternal consumption of alcohol during pregnancy affecting 2%–5% of the Western population. In Xenopus laevis studies, we showed that alcohol exposure during early gastrulation reduces retinoic acid (RA)
B. Petrelli, A. Oztürk, M. Pind, H. Ayele, A. Fainsod, G. G. Hicks   +5 more
doaj   +1 more source

Tunicate gastrulation [PDF]

, 2020
Tunicates are a diverse group of invertebrate marine chordates that includes the larvaceans, thaliaceans, and ascidians. Because of their unique evolutionary position as the sister group of the vertebrates, tunicates are invaluable as a comparative model and hold the promise of revealing both conserved and derived features of chordate gastrulation ...
Konner M, Winkley, Matthew J, Kourakis, Anthony W, DeTomaso, Michael T, Veeman, William C, Smith   +4 more
openaire   +2 more sources

Virtual cells in a virtual microenvironment recapitulate early development-like patterns in human pluripotent stem cell colonies

Stem Cell Reports, 2023
Summary: The mechanism by which morphogenetic signals engage the regulatory networks responsible for early embryonic tissue patterning is incompletely understood.
Himanshu Kaul, Nicolas Werschler, Ross D. Jones, M. Mona Siu, Mukul Tewary, Andrew Hagner, Joel Ostblom, Daniel Aguilar-Hidalgo, Peter W. Zandstra   +8 more
doaj   +1 more source

A hypomorphic mutation in Pold1 disrupts the coordination of embryo size expansion and morphogenesis during gastrulation

Biology Open, 2022
Formation of a properly sized and patterned embryo during gastrulation requires a well-coordinated interplay between cell proliferation, lineage specification and tissue morphogenesis.
Tingxu Chen, Heather Alcorn, Sujan Devbhandari, Dirk Remus, Elizabeth Lacy, Danwei Huangfu, Kathryn V. Anderson   +6 more
doaj   +1 more source

Rho1 activation recapitulates early gastrulation events in the ventral, but not dorsal, epithelium of Drosophila embryos

eLife, 2020
Ventral furrow formation, the first step in Drosophila gastrulation, is a well-studied example of tissue morphogenesis. Rho1 is highly active in a subset of ventral cells and is required for this morphogenetic event.
Ashley Rich, Richard G Fehon, Michael Glotzer   +2 more
doaj   +1 more source

The Adaptor Protein Lurap1 Is Required for Cell Cohesion during Epiboly Movement in Zebrafish

Biology, 2021
Cell adhesion and polarized cellular behaviors play critical roles in a wide variety of morphogenetic events. In the zebrafish embryo, epiboly represents an important process of epithelial morphogenesis that involves differential cell adhesion and ...
Ji-Tong Li, Xiao-Ning Cheng, Chong Zhang, De-Li Shi, Ming Shao   +4 more
doaj   +1 more source