Interspecies control of development during mammalian gastrulation
, 2023 Gastrulation represents a pivotal phase of development and aberrations during this period can have major consequences, from minor anatomical deviations to severe congenital defects.
Simpson, Luke, Alberio, Ramiro
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Gastrulation in C. elegans [PDF]
WormBook, 2005 Gastrulation is the process by which the germ layers become positioned in an embryo. C. elegans gastrulation serves as a model for studying the molecular mechanisms of diverse cellular and developmental phenomena, including morphogenesis, cell polarization, cell-cell signaling, actomyosin contraction and cell-cell adhesion.
Jeremy, Nance +2 more
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Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in flies
eLife, 2016 Gastrulation constitutes a fundamental yet diverse morphogenetic process of metazoan development. Modes of gastrulation range from stochastic translocation of individual cells to coordinated infolding of an epithelial sheet.
Silvia Urbansky +3 more
doaj +1 more source
MIGC: Pseudotime differentially expressed genes detection with mutual information. [PDF]
Quant BiolAbstract Trajectory analysis of single‐cell RNA sequencing (scRNA‐seq) data provides insights into cell differentiation and the underlying mechanisms at the gene level. Although various pseudotime inference methods have been proposed, the detection of pseudotime differentially expressed genes (DEGs) mainly relies on generalized additive model fitting ...
Li J, Yuan Y.
europepmc +2 more sources
Inhibition of the synthesis of glycosphingolipid by a ceramide analogue (PPMP) in the gastrulation of Bufo arenarum [PDF]
, 2000 In the present study the role of glycosphingolipids (GSL) in amphibian development was investigated. We analysed the de novo synthesis of neutral GSL and gangliosides through the initial stages of Bufo arenarnm embryo development and their participation ...
Analía Fuentes +5 more
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Hox genes control vertebrate body elongation by collinear Wnt repression
eLife, 2015 In vertebrates, the total number of vertebrae is precisely defined. Vertebrae derive from embryonic somites that are continuously produced posteriorly from the presomitic mesoderm (PSM) during body formation.
Nicolas Denans +2 more
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Retinoic Acid is Required for Normal Morphogenetic Movements During Gastrulation
Frontiers in Cell and Developmental Biology, 2022 Retinoic acid (RA) is a central regulatory signal that controls numerous developmental processes in vertebrate embryos. Although activation of Hox expression is considered one of the earliest functions of RA signaling in the embryo, there is evidence ...
Michal Gur +3 more
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Wnt5b integrates Fak1a to mediate gastrulation cell movements via Rac1 and Cdc42 [PDF]
Open Biology, 2020 Focal adhesion kinase (FAK) mediates vital cellular pathways during development. Despite its necessity, how FAK regulates and integrates with other signals during early embryogenesis remains poorly understood.
I-Chen Hung +5 more
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Ingression-type cell migration drives vegetal endoderm internalisation in the Xenopus gastrula
eLife, 2017 During amphibian gastrulation, presumptive endoderm is internalised as part of vegetal rotation, a large-scale movement that encompasses the whole vegetal half of the embryo. It has been considered a gastrulation process unique to amphibians, but we show
Jason WH Wen, Rudolf Winklbauer
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Furry is required for cell movements during gastrulation and functionally interacts with NDR1
Scientific Reports, 2021 Gastrulation is a key event in animal embryogenesis during which germ layer precursors are rearranged and the embryonic axes are established. Cell polarization is essential during gastrulation, driving asymmetric cell division, cell movements, and cell ...
Ailen S. Cervino +5 more
doaj +1 more source