Results 41 to 50 of about 69,462 (264)

Mechanical tension promotes formation of gastrulation-like nodes and patterns mesoderm specification in human embryonic stem cells

Developmental Cell, 2020
Summary Embryogenesis is directed by morphogens that induce differentiation within a defined tissue geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) adhesions and is modulated by cell tension and tissue-level ...
Jonathon M. Muncie, Nadia M. E. Ayad, J. Lakins, X. Xue, Jianping Fu, V. Weaver   +5 more
semanticscholar   +1 more source

Live imaging of whole mouse embryos during gastrulation : migration analyses of epiblast and mesodermal cells [PDF]

, 2013
During gastrulation in the mouse embryo, dynamic cell movements including epiblast invagination and mesodermal layer expansion lead to the establishment of the three-layered body plan.
Kenichi Nakazato (431530), Kenichi Nakazato, Philipp J Keller, Nakazato, Kenichi, Keller, Philipp J., Ernst H. K. Stelzer (243520), Shigenori Nonaka (115461), Nonaka, Shigenori, Takehiko Ichikawa (431529), Philipp J. Keller (262647), Hiroko Kajiura-Kobayashi (431531), Hiroko Kajiura-Kobayashi, Mochizuki, Atsushi, Kajiura-Kobayashi, Hiroko, Ernst H K Stelzer, Takehiko Ichikawa, Stelzer, Ernst H. K., Shigenori Nonaka, Ichikawa, Takehiko, Atsushi Mochizuki, Atsushi Mochizuki (36572)   +20 more
core   +1 more source

The major β-catenin/E-cadherin junctional binding site is a primary molecular mechano-transductor of differentiation in vivo

eLife, 2018
In vivo, the primary molecular mechanotransductive events mechanically initiating cell differentiation remain unknown. Here we find the molecular stretching of the highly conserved Y654-β-catenin-D665-E-cadherin binding site as mechanically induced by ...
Jens-Christian Röper, Démosthène Mitrossilis, Guillaume Stirnemann, François Waharte, Isabel Brito, Maria-Elena Fernandez-Sanchez, Marc Baaden, Jean Salamero, Emmanuel Farge   +8 more
doaj   +1 more source

Some Questions and Answers About the Role of Hox Temporal Collinearity in Vertebrate Axial Patterning

Frontiers in Cell and Developmental Biology, 2019
The vertebrate anterior-posterior (A-P = craniocaudal) axis is evidently made by a timing mechanism. Evidence has accumulated that tentatively identifies the A-P timer as being or involving Hox temporal collinearity (TC). Here, I focus on the two current
Antony J. Durston
doaj   +1 more source

Mouse gastrulation: coordination of tissue patterning, specification and diversification of cell fate

Mechanisms of Development, 2020
During mouse embryonic development a mass of pluripotent epiblast tissue is transformed during gastrulation to generate the three definitive germ layers: endoderm, mesoderm, and ectoderm.
E. Bardot, A. Hadjantonakis
semanticscholar   +1 more source

Reconstruction of distinct vertebrate gastrulation modes via modulation of key cell behaviors in the chick embryo

bioRxiv, 2021
The morphology of gastrulation driving the internalisation of the mesoderm and endoderm differs dramatically among vertebrate species. It ranges from involution of epithelial sheets of cells through a circular blastopore in amphibians to ingression of ...
Manli Chuai, Guillermo Serrano Nájera, M. Serra, L. Mahadevan, Cornelis J. Weijer   +4 more
semanticscholar   +1 more source

Comparative Expression of Zebrafish Lats1 and Lats2 and Their Implication in Gastrulation Movements [PDF]

, 2009
Large tumor suppressor (Lats) is a Ser/Thr kinase, and it presents an important function in tumor suppression. lats was originally identified in Drosophila and recently in mammals. In mammals, it contains two homologues, lats1 and lats2.
Pei, De-Sheng, Sun, YH, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China, Chen, Chun-Hong, Sun, Yong-Hua, Zhu, Zuo-Yan   +4 more
core   +1 more source

Loss of Apela Peptide in Mice Causes Low Penetrance Embryonic Lethality and Defects in Early Mesodermal Derivatives

Cell Reports, 2017
Apela (also known as Elabela, Ende, and Toddler) is a small signaling peptide that activates the G-protein-coupled receptor Aplnr to stimulate cell migration during zebrafish gastrulation.
Laina Freyer, Chih-Wei Hsu, Sonja Nowotschin, Andrea Pauli, Junji Ishida, Keiji Kuba, Akiyoshi Fukamizu, Alexander F. Schier, Pamela A. Hoodless, Mary E. Dickinson, Anna-Katerina Hadjantonakis   +10 more
doaj   +1 more source

Utilizing Playdoh in the Classroom to Construct a 3D Model Depicting Cellular Movements and Tissue Remodeling during Human Gastrulation, Early Organogenesis, and Embryonic Folding

Journal of Microbiology & Biology Education, 2021
In classroom studies of mammalian embryology, students must fully grasp the cellular and tissue remodeling needed to initiate gastrulation to ensure comprehension of forthcoming developmental processes such as tissue specification and organogenesis ...
Ryan Hesterman, Shannon Rose, Will LeFever, Ryan Stewart, Martina Krone, Camryn Holihan, Kristin Ackerman   +6 more
doaj   +1 more source

Candidate Heterotaxy Gene FGFR4 Is Essential for Patterning of the Left-Right Organizer in Xenopus

Frontiers in Physiology, 2018
Congenital heart disease (CHD) is the most common birth defect, yet its genetic causes continue to be obscure. Fibroblast growth factor receptor 4 (FGFR4) recently emerged in a large patient exome sequencing study as a candidate disease gene for CHD and ...
Emily Sempou, Osaamah Ali Lakhani, Sarah Amalraj, Mustafa K. Khokha   +3 more
doaj   +1 more source