Results 41 to 50 of about 62,161 (225)
A mechanochemical model recapitulates distinct vertebrate gastrulation modes [PDF]
, 2023 During vertebrate gastrulation, an embryo transforms from a layer of epithelial cells into a multilayered gastrula. This process requires the coordinated movements of hundreds to tens of thousands of cells, depending on the organism. In the chick embryo,
Chuai, Manli +10 more
core +1 more source
Folded gastrulation and T48 drive the evolution of coordinated mesoderm internalization in flies
eLife, 2016 Gastrulation constitutes a fundamental yet diverse morphogenetic process of metazoan development. Modes of gastrulation range from stochastic translocation of individual cells to coordinated infolding of an epithelial sheet.
Silvia Urbansky +3 more
doaj +1 more source
, 2015 Neural tube defects including spina bifida are common and severe congenital disorders. In mice, mutations in more than 200 genes can result in neural tube defects.
Jennifer K Heppert +21 more
core +1 more source
Retinoic Acid is Required for Normal Morphogenetic Movements During Gastrulation
Frontiers in Cell and Developmental Biology, 2022 Retinoic acid (RA) is a central regulatory signal that controls numerous developmental processes in vertebrate embryos. Although activation of Hox expression is considered one of the earliest functions of RA signaling in the embryo, there is evidence ...
Michal Gur +3 more
doaj +1 more source
Wnt5b integrates Fak1a to mediate gastrulation cell movements via Rac1 and Cdc42 [PDF]
Open Biology, 2020 Focal adhesion kinase (FAK) mediates vital cellular pathways during development. Despite its necessity, how FAK regulates and integrates with other signals during early embryogenesis remains poorly understood.
I-Chen Hung +5 more
doaj +1 more source
Hox genes control vertebrate body elongation by collinear Wnt repression
eLife, 2015 In vertebrates, the total number of vertebrae is precisely defined. Vertebrae derive from embryonic somites that are continuously produced posteriorly from the presomitic mesoderm (PSM) during body formation.
Nicolas Denans +2 more
doaj +1 more source
Furry is required for cell movements during gastrulation and functionally interacts with NDR1
Scientific Reports, 2021 Gastrulation is a key event in animal embryogenesis during which germ layer precursors are rearranged and the embryonic axes are established. Cell polarization is essential during gastrulation, driving asymmetric cell division, cell movements, and cell ...
Ailen S. Cervino +5 more
doaj +1 more source
Nematode Gastrulation: Having a BLASTocoel! [PDF]
, 2005 During gastrulation of the nematode worm Caenorhabditis elegans, individual cells ingress into a solid ball of cells. Gastrulation in a basal nematode, in contrast, has now been found to occur by invagination into a blastocoel, revealing an unanticipated
Joshi, Pradeep M., Rothman, Joel H.
core +1 more source
Ingression-type cell migration drives vegetal endoderm internalisation in the Xenopus gastrula
eLife, 2017 During amphibian gastrulation, presumptive endoderm is internalised as part of vegetal rotation, a large-scale movement that encompasses the whole vegetal half of the embryo. It has been considered a gastrulation process unique to amphibians, but we show
Jason WH Wen, Rudolf Winklbauer
doaj +1 more source
Substrate stiffness affects early differentiation events in embryonic stem cells [PDF]
European Cells & Materials, 2009 Embryonic stem cells (ESC) are both a potential source of cells for tissue replacement therapies and an accessible tool to model early embryonic development.
ND Evans +8 more
doaj