Results 51 to 60 of about 62,161 (225)

Alternative splicing dynamics during gastrulation in mouse embryo

Scientific Reports
Alternative splicing (AS) plays an essential role in development, differentiation and carcinogenesis. However, the mechanisms underlying splicing regulation during mouse embryo gastrulation remain unclear.
Wei Wang, Yu Zhang, Yuanyuan Zhai, Wuritu Yang, Yongqiang Xing   +4 more
doaj   +1 more source

Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation

Nature Communications, 2023
Understanding of the molecular drivers of lineage diversification and tissue patterning during primary germ layer development requires in-depth knowledge of the dynamic molecular trajectories of cell lineages across a series of developmental stages of ...
Ran Wang, Xianfa Yang, Jiehui Chen, Lin Zhang, Jonathan A. Griffiths, Guizhong Cui, Yingying Chen, Yun Qian, Guangdun Peng, Jinsong Li, Liantang Wang, John C. Marioni, Patrick P. L. Tam, Naihe Jing   +13 more
doaj   +1 more source

Morphological changes and two Nodal paralogs drive left-right asymmetry in the squamate veiled chameleon (C. calyptratus)

Frontiers in Cell and Developmental Biology, 2023
The ancestral mode of left-right (L-R) patterning involves cilia in the L-R organizer. However, the mechanisms regulating L-R patterning in non-avian reptiles remains an enigma, since most squamate embryos are undergoing organogenesis at oviposition.
Natalia A. Shylo, Sarah E. Smith, Andrew J. Price, Fengli Guo, Melainia McClain, Paul A. Trainor, Paul A. Trainor   +6 more
doaj   +1 more source

Gastrulation in the sea urchin

, 2020
Gastrulation is arguably the most important evolutionary innovation in the animal kingdom. This process provides the basic embryonic architecture, an inner layer separated from an outer layer, from which all animal forms arise. An extraordinarily simple and elegant process of gastrulation is observed in the sea urchin embryo. The cells participating in
McClay, David R., Warner, Jacob, Martik, Megan, Miranda, Esther, Slota, Leslie   +4 more
openaire   +4 more sources

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

eLife, 2018
During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on micropatterned surfaces ...
Sophie M Morgani, Jakob J Metzger, Jennifer Nichols, Eric D Siggia, Anna-Katerina Hadjantonakis   +4 more
doaj   +1 more source

Charting Morphotoxicity With Complementary Embryo Models

Advanced Healthcare Materials, EarlyView.
Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Dorian G. Luijkx, Pauline L. Balder, Romy M. L. Verhagen, Vinidhra Shankar, Barry Jutten, Pinak Samal, Timo Rademakers, Clemens A. van Blitterswijk, Stefan Giselbrecht, Erik J. Vrij   +9 more
wiley   +1 more source

TRPM7 regulates gastrulation during vertebrate embryogenesis [PDF]

, 2011
During gastrulation, cells in the dorsal marginal zone polarize, elongate, align and intercalate to establish the physical body axis of the developing embryo.
Sato, Akira, Komiya, Yuko, Habas, Raymond, Liu, Wei, Loren W. Runnels, Yuko Komiya, Akira Sato, Mezzacappa, Courtney, Li-Ting Su, Deepak K. Khadka, Courtney Mezzacappa, Su, Li-Ting, Runnels, Loren W., Raymond Habas, Wei Liu, Khadka, Deepak K.   +15 more
core   +1 more source

Recent advances in understanding cell types during human gastrulation [PDF]

, 2022
Gastrulation is a fundamental process during embryonic development, conserved across all multicellular animals(1). In the majority of metazoans, gastrulation is characterised by large scale morphogenetic remodeling, leading to the conversion of an early ...
Tyser, Richard C.V., Srinivas, Shankar
core   +2 more sources

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source