Results 51 to 60 of about 62,967 (236)

Hox genes control vertebrate body elongation by collinear Wnt repression

eLife, 2015
In vertebrates, the total number of vertebrae is precisely defined. Vertebrae derive from embryonic somites that are continuously produced posteriorly from the presomitic mesoderm (PSM) during body formation.
Nicolas Denans, Tadahiro Iimura, Olivier Pourquié   +2 more
doaj   +1 more source

Furry is required for cell movements during gastrulation and functionally interacts with NDR1

Scientific Reports, 2021
Gastrulation is a key event in animal embryogenesis during which germ layer precursors are rearranged and the embryonic axes are established. Cell polarization is essential during gastrulation, driving asymmetric cell division, cell movements, and cell ...
Ailen S. Cervino, Bruno Moretti, Carsten Stuckenholz, Hernán E. Grecco, Lance A. Davidson, M. Cecilia Cirio   +5 more
doaj   +1 more source

Ingression-type cell migration drives vegetal endoderm internalisation in the Xenopus gastrula

eLife, 2017
During amphibian gastrulation, presumptive endoderm is internalised as part of vegetal rotation, a large-scale movement that encompasses the whole vegetal half of the embryo. It has been considered a gastrulation process unique to amphibians, but we show
Jason WH Wen, Rudolf Winklbauer
doaj   +1 more source

Substrate stiffness affects early differentiation events in embryonic stem cells [PDF]

European Cells & Materials, 2009
Embryonic stem cells (ESC) are both a potential source of cells for tissue replacement therapies and an accessible tool to model early embryonic development.
ND Evans, C Minelli, E Gentleman, V LaPointe, SN Patankar, M Kallivretaki, X Chen, CJ Roberts, MM Stevens   +8 more
doaj  

Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation

Nature Communications, 2023
Understanding of the molecular drivers of lineage diversification and tissue patterning during primary germ layer development requires in-depth knowledge of the dynamic molecular trajectories of cell lineages across a series of developmental stages of ...
Ran Wang, Xianfa Yang, Jiehui Chen, Lin Zhang, Jonathan A. Griffiths, Guizhong Cui, Yingying Chen, Yun Qian, Guangdun Peng, Jinsong Li, Liantang Wang, John C. Marioni, Patrick P. L. Tam, Naihe Jing   +13 more
doaj   +1 more source

Morphological changes and two Nodal paralogs drive left-right asymmetry in the squamate veiled chameleon (C. calyptratus)

Frontiers in Cell and Developmental Biology, 2023
The ancestral mode of left-right (L-R) patterning involves cilia in the L-R organizer. However, the mechanisms regulating L-R patterning in non-avian reptiles remains an enigma, since most squamate embryos are undergoing organogenesis at oviposition.
Natalia A. Shylo, Sarah E. Smith, Andrew J. Price, Fengli Guo, Melainia McClain, Paul A. Trainor, Paul A. Trainor   +6 more
doaj   +1 more source

Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation

Cell Reports, 2017
Summary The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE) lineages coincident with implantation of the embryo. The epiblast subsequently undergoes considerable expansion of cell numbers prior to gastrulation.
Hisham Mohammed, Irene Hernando-Herraez, Aurora Savino, A. Scialdone, I. Macaulay, C. Mulas, Tamir Chandra, T. Voet, W. Dean, J. Nichols, J. Marioni, W. Reik   +11 more
semanticscholar   +1 more source

Gastrulation and germ layer formation in the sea anemone Nematostella vectensis and other cnidarians.

Mechanisms of Development, 2020
Among the basally branching metazoans, cnidarians display well-defined gastrulation processes leading to a diploblastic body plan, consisting of an endodermal and an ectodermal cell layer.
U. Technau
semanticscholar   +1 more source

Alternative splicing dynamics during gastrulation in mouse embryo

Scientific Reports
Alternative splicing (AS) plays an essential role in development, differentiation and carcinogenesis. However, the mechanisms underlying splicing regulation during mouse embryo gastrulation remain unclear.
Wei Wang, Yu Zhang, Yuanyuan Zhai, Wuritu Yang, Yongqiang Xing   +4 more
doaj   +1 more source

Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

eLife, 2018
During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on micropatterned surfaces ...
Sophie M Morgani, Jakob J Metzger, Jennifer Nichols, Eric D Siggia, Anna-Katerina Hadjantonakis   +4 more
doaj   +1 more source