Results 51 to 60 of about 62,969 (218)

Substrate stiffness affects early differentiation events in embryonic stem cells [PDF]

European Cells & Materials, 2009
Embryonic stem cells (ESC) are both a potential source of cells for tissue replacement therapies and an accessible tool to model early embryonic development.
ND Evans, C Minelli, E Gentleman, V LaPointe, SN Patankar, M Kallivretaki, X Chen, CJ Roberts, MM Stevens   +8 more
doaj  

Alternative splicing dynamics during gastrulation in mouse embryo

Scientific Reports
Alternative splicing (AS) plays an essential role in development, differentiation and carcinogenesis. However, the mechanisms underlying splicing regulation during mouse embryo gastrulation remain unclear.
Wei Wang, Yu Zhang, Yuanyuan Zhai, Wuritu Yang, Yongqiang Xing   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Gastrulation in the sea urchin

, 2020
Gastrulation is arguably the most important evolutionary innovation in the animal kingdom. This process provides the basic embryonic architecture, an inner layer separated from an outer layer, from which all animal forms arise. An extraordinarily simple and elegant process of gastrulation is observed in the sea urchin embryo. The cells participating in
McClay, David R., Warner, Jacob, Martik, Megan, Miranda, Esther, Slota, Leslie   +4 more
openaire   +4 more sources

Comparative Expression of Zebrafish Lats1 and Lats2 and Their Implication in Gastrulation Movements

, 2009
Large tumor suppressor (Lats) is a Ser/Thr kinase, and it presents an important function in tumor suppression. lats was originally identified in Drosophila and recently in mammals. In mammals, it contains two homologues, lats1 and lats2.
Pei, De-Sheng, Sun, YH, Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China, Chen, Chun-Hong, Sun, Yong-Hua, Zhu, Zuo-Yan   +4 more
core   +1 more source

A mechanochemical model recapitulates distinct vertebrate gastrulation modes [PDF]

, 2023
During vertebrate gastrulation, an embryo transforms from a layer of epithelial cells into a multilayered gastrula. This process requires the coordinated movements of hundreds to tens of thousands of cells, depending on the organism. In the chick embryo,
Chuai, Manli, Serrano Nájera, Guillermo, Santhosh, Sreejith, Mahadevan, L., Plum, Alex M., Serra, Mattia, Weijer, Cornelis, Weijer, Cornelis J.; id_orcid, Mahadevan, L, Spandan, Vamsi, Plum, Alex   +10 more
core   +1 more source

Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

eLife, 2018
During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on micropatterned surfaces ...
Sophie M Morgani, Jakob J Metzger, Jennifer Nichols, Eric D Siggia, Anna-Katerina Hadjantonakis   +4 more
doaj   +1 more source

Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation

Nature Communications, 2023
Understanding of the molecular drivers of lineage diversification and tissue patterning during primary germ layer development requires in-depth knowledge of the dynamic molecular trajectories of cell lineages across a series of developmental stages of ...
Ran Wang, Xianfa Yang, Jiehui Chen, Lin Zhang, Jonathan A. Griffiths, Guizhong Cui, Yingying Chen, Yun Qian, Guangdun Peng, Jinsong Li, Liantang Wang, John C. Marioni, Patrick P. L. Tam, Naihe Jing   +13 more
doaj   +1 more source

Morphological changes and two Nodal paralogs drive left-right asymmetry in the squamate veiled chameleon (C. calyptratus)

Frontiers in Cell and Developmental Biology, 2023
The ancestral mode of left-right (L-R) patterning involves cilia in the L-R organizer. However, the mechanisms regulating L-R patterning in non-avian reptiles remains an enigma, since most squamate embryos are undergoing organogenesis at oviposition.
Natalia A. Shylo, Sarah E. Smith, Andrew J. Price, Fengli Guo, Melainia McClain, Paul A. Trainor, Paul A. Trainor   +6 more
doaj   +1 more source

Niche‐Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids

Advanced Science, EarlyView.
Compared to E8, mTeSR1 culture downregulated WNT and TGF‑β signaling, and upregulated neural differentiation pathways, enhancing neural priming. Under skin organoid induction conditions, mTeSR1‑cultured hESCs generated organoids with significantly higher neuroepithelial differentiation.
Zhongliang Chen, Liangxia Jiang, Xianbin Wang, Lili Zhong, Rongcan Luo, Min Su, Liangzhao Chu, Peng Luo   +7 more
wiley   +1 more source