Results 71 to 80 of about 69,462 (264)

Nematode Gastrulation: Having a BLASTocoel! [PDF]

, 2005
During gastrulation of the nematode worm Caenorhabditis elegans, individual cells ingress into a solid ball of cells. Gastrulation in a basal nematode, in contrast, has now been found to occur by invagination into a blastocoel, revealing an unanticipated
Joshi, Pradeep M., Rothman, Joel H.
core   +1 more source

Substrate stiffness affects early differentiation events in embryonic stem cells [PDF]

European Cells & Materials, 2009
Embryonic stem cells (ESC) are both a potential source of cells for tissue replacement therapies and an accessible tool to model early embryonic development.
ND Evans, C Minelli, E Gentleman, V LaPointe, SN Patankar, M Kallivretaki, X Chen, CJ Roberts, MM Stevens   +8 more
doaj  

Alternative splicing dynamics during gastrulation in mouse embryo

Scientific Reports
Alternative splicing (AS) plays an essential role in development, differentiation and carcinogenesis. However, the mechanisms underlying splicing regulation during mouse embryo gastrulation remain unclear.
Wei Wang, Yu Zhang, Yuanyuan Zhai, Wuritu Yang, Yongqiang Xing   +4 more
doaj   +1 more source

Time space and single-cell resolved tissue lineage trajectories and laterality of body plan at gastrulation

Nature Communications, 2023
Understanding of the molecular drivers of lineage diversification and tissue patterning during primary germ layer development requires in-depth knowledge of the dynamic molecular trajectories of cell lineages across a series of developmental stages of ...
Ran Wang, Xianfa Yang, Jiehui Chen, Lin Zhang, Jonathan A. Griffiths, Guizhong Cui, Yingying Chen, Yun Qian, Guangdun Peng, Jinsong Li, Liantang Wang, John C. Marioni, Patrick P. L. Tam, Naihe Jing   +13 more
doaj   +1 more source

Morphological changes and two Nodal paralogs drive left-right asymmetry in the squamate veiled chameleon (C. calyptratus)

Frontiers in Cell and Developmental Biology, 2023
The ancestral mode of left-right (L-R) patterning involves cilia in the L-R organizer. However, the mechanisms regulating L-R patterning in non-avian reptiles remains an enigma, since most squamate embryos are undergoing organogenesis at oviposition.
Natalia A. Shylo, Sarah E. Smith, Andrew J. Price, Fengli Guo, Melainia McClain, Paul A. Trainor, Paul A. Trainor   +6 more
doaj   +1 more source

Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation

Cell Reports, 2017
Summary The mouse inner cell mass (ICM) segregates into the epiblast and primitive endoderm (PrE) lineages coincident with implantation of the embryo. The epiblast subsequently undergoes considerable expansion of cell numbers prior to gastrulation.
Hisham Mohammed, Irene Hernando-Herraez, Aurora Savino, A. Scialdone, I. Macaulay, C. Mulas, Tamir Chandra, T. Voet, W. Dean, J. Nichols, J. Marioni, W. Reik   +11 more
semanticscholar   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

From genes to germ layers: virtual twins of gastruloids

npj Systems Biology and Applications
Human gastrulation remains a black box due to ethical and technical reasons. Human pluripotent stem cell-based 2D micropatterns and 3D organoids (gastruloids) recapitulate aspects of human gastrulation.
Leona M. Irwin, Shaun M. Cowley, Himanshu Kaul   +2 more
doaj   +1 more source

Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

eLife, 2018
During gastrulation epiblast cells exit pluripotency as they specify and spatially arrange the three germ layers of the embryo. Similarly, human pluripotent stem cells (PSCs) undergo spatially organized fate specification on micropatterned surfaces ...
Sophie M Morgani, Jakob J Metzger, Jennifer Nichols, Eric D Siggia, Anna-Katerina Hadjantonakis   +4 more
doaj   +1 more source

Gastrulation and germ layer formation in the sea anemone Nematostella vectensis and other cnidarians.

Mechanisms of Development, 2020
Among the basally branching metazoans, cnidarians display well-defined gastrulation processes leading to a diploblastic body plan, consisting of an endodermal and an ectodermal cell layer.
U. Technau
semanticscholar   +1 more source