Results 91 to 100 of about 81,569 (272)
Epiblast morphogenesis before gastrulation
Developmental Biology, 2015 The epiblast is a single cell-layered epithelium which generates through gastrulation all tissues in an amniote embryo proper. Specification of the epiblast as a cell lineage in early development is coupled with that of the trophoblast and hypoblast, two lineages dedicated to forming extramebryonic tissues.
openaire +2 more sources
Pitfalls and missing links in current understanding of 4D genomes
Quantitative Biology, Volume 14, Issue 2, June 2026.Abstract The spatial and temporal organization of the genome—collectively termed the 4D genome—is pivotal for regulating gene expression, maintaining genome stability, and guiding development. The convergence of chromosome conformation capture technologies, super‐resolution microscopy, and single‐cell epigenomics has transformed our understanding of ...
Michael Q. Zhang
wiley +1 more source
Mechanobiology in Stem Cell‐Based Bioprinting
Cell Proliferation, Volume 59, Issue 5, May 2026.Mechanobiology in stem cell‐based bioprinting is an emerging field that bridges the mechanical conditions of the bioprinting process with the regulation of stem cell behaviour for engineering living tissues. Stresses encountered during bioprinting, together with the mechanical properties of bioinks, play a critical role in regulating stem cell ...
Supeng Ding, Tiankun Liu, Rui Yao
wiley +1 more source
Substrate for Thyroid Hormone Synthesis: Biochemistry, Evolution, and Physiology
The FASEB Journal, Volume 40, Issue 8, 30 April 2026.Two proposed sequence of events for thyroxine formation in patients expressing mutant thyroglobulin. (A) (1) TSH stimulation drives expression of misfolded TG. (2) Unremitting ER stress. (3) Stress‐induced cell death. (4) Dead thyrocytes release their contents. (5) The contents become iodinated. (6) Forming thyroxine.
Crystal Young, Peter Arvan
wiley +1 more source
eLife, 2018 Understanding the coordination of the forces generated in embryos by two processes, convergent extension and convergent thickening, is key to understanding how a hollow sphere of cells develops into an elongated embryo.
Shinuo Weng, John B Wallingford
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Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development
Advanced Science, Volume 13, Issue 19, 2 April 2026.This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen +11 more
wiley +1 more source
eLife, 2018 Indirect evidence suggests that blastopore closure during gastrulation of anamniotes, including amphibians such as Xenopus laevis, depends on circumblastoporal convergence forces generated by the marginal zone (MZ), but direct evidence is lacking.
David R Shook +3 more
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Spatial and temporal patterns of distribution of the gap junction protein connexin43 during mouse gastrulation and organogenesis [PDF]
, 1992 Connexin43 (Cx43) is a member of the family of channel-forming proteins that make up the gap junction and are believed to provide pathways for cell-cell exchange of developmental signals.
Biswal, Sandip +2 more
core
Frontiers in AquacultureIntroductionCommercial production of Atlantic halibut (Hippoglossus hippoglossus) has many obstacles, such as low and highly variable egg quality and survival rates during early developmental stages.
Nils Niepagen +3 more
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Pitx2c orchestrates embryonic axis extension via mesendodermal cell migration
eLife, 2018 Pitx2c, a homeodomain transcription factor, is classically known for its left-right patterning role. However, an early wave of pitx2 expression occurs at the onset of gastrulation in several species, indicating a possible earlier role that remains ...
Michelle M Collins +5 more
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