A system to enrich for primitive streak-derivatives, definitive endoderm and mesoderm, from pluripotent cells in culture. [PDF]
PLoS ONE, 2012 Two lineages of endoderm develop during mammalian embryogenesis, the primitive endoderm in the pre-implantation blastocyst and the definitive endoderm at gastrulation.
Svetlana Vassilieva +6 more
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Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes [PDF]
eLife, 2017 The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes – carotid body glomus cells, and ‘pulmonary neuroendocrine cells’ (PNECs) - are obscure.
Dorit Hockman +16 more
doaj +3 more sources
Induced Pluripotent Stem Cells as a Tool to Decipher the Normal and Abnormal Development of the Esophagus and Trachea from Normal Morphogenesis to Esophageal Atresia, Tracheomalacia, and Laryngo–Tracheal Clefts [PDF]
CellsThe development of the esophagus and trachea following the septation of the anterior foregut is a highly regulated process involving bidirectional communication between the endoderm and mesoderm.
Yuxuan Zhang +3 more
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A novel method for generating induced pluripotent stem cell (iPSC)-derived alveolar organoids: a comparison of their ability depending on iPSC origin [PDF]
Organoid, 2023 Background Alveolar organoids may be useful tools in drug discovery for lung diseases, such as chronic obstructive pulmonary disease, and for studying the effects of respiratory viruses, such as severe acute respiratory syndrome coronavirus 2.
Min Jae Lim, Ayoung Jo, Sung-Won Kim
doaj +1 more source
Cells, 2021 The endoderm, differentiated from human induced pluripotent stem cells (iPSCs), can differentiate into the small intestine and liver, which are vital for drug absorption and metabolism.
Shimeng Qiu +6 more
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T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation
eLife, 2023 Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various biological processes, including embryonic development and cellular differentiation. Despite much progress over the past decade, the genome-wide annotation of lncRNAs remains
Alexandro Landshammer +19 more
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Mature Mediastinal Teratoma [PDF]
Journal of Clinical and Diagnostic Research, 2015 A teratoma is a tumour with tissue or organ components resembling normal derivatives of more than one germ layer. We present a case of mediastinal mature teratoma as they have a low incidence rate.
Chikka Narasimhaiah Anushree +1 more
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In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors
Cell Reports, 2017 T-box transcription factors T/Brachyury homolog A (Ta) and Tbx16 are essential for correct mesoderm development in zebrafish. The downstream transcriptional networks guiding their functional activities are poorly understood.
Andrew C. Nelson +5 more
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Sequencing and analysis of the gastrula transcriptome of the brittle star Ophiocoma wendtii [PDF]
, 2012 Background The gastrula stage represents the point in development at which the three primary germ layers diverge. At this point the gene regulatory networks that specify the germ layers are established and the genes that define the differentiated states ...
Garey, James R. +4 more
core +2 more sources
In vitro generation of human pluripotent stem cell derived lung organoids
eLife, 2015 Recent breakthroughs in 3-dimensional (3D) organoid cultures for many organ systems have led to new physiologically complex in vitro models to study human development and disease.
Briana R Dye +12 more
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