Results 41 to 50 of about 55,791 (279)

Naïve human pluripotent stem cells respond to Wnt, Nodal and LIF signalling to produce expandable naïve extra-embryonic endoderm

open access: yesDevelopment, 2019
Embryonic stem cells (ESCs) exist in at least two states that transcriptionally resemble different stages of embryonic development. Naïve ESCs resemble peri-implantation stages and primed ESCs the pre-gastrulation epiblast.
Madeleine Linneberg-Agerholm   +5 more
semanticscholar   +1 more source

Endoderm-Derived Myeloid-like Metaphocytes in Zebrafish Gill Mediate Soluble Antigen-Induced Immunity

open access: yesCell Reports, 2020
Summary: Immune cells in the mucosal barriers of vertebrates are highly heterogeneous in their origin and function. This heterogeneity is further exemplified by the recent discovery of ectoderm-derived immune cells—metaphocytes in zebrafish epidermis ...
Xi Lin   +4 more
doaj   +1 more source

Genome-scale screens identify JNK/JUN signaling as a barrier for pluripotency exit and endoderm differentiation

open access: yesNature Genetics, 2019
Human embryonic stem cells (ESCs) and human induced pluripotent stem cells hold great promise for cell-based therapies and drug discovery. However, homogeneous differentiation remains a major challenge, highlighting the need for understanding ...
Qing V. Li   +23 more
semanticscholar   +1 more source

Complete Dorsal Pancreatic Agenesis and Unilateral Renal Agenesis: First Case Report and Review of Literature [PDF]

open access: yesInternational Journal of Anatomy Radiology and Surgery, 2016
Dorsal pancreatic agenesis is very rare congenital anomaly of pancreas. Patients with this anomaly are usually asymptomatic or may present with abdominal pain or acute or chronic pancreatitis.
Manjit Motilal Bagul, Purva Traipathi
doaj   +1 more source

Single-cell RNA-seq reveals novel regulators of human embryonic stem cell differentiation to definitive endoderm

open access: yesGenome Biology, 2016
Human pluripotent stem cells offer the best available model to study the underlying cellular and molecular mechanisms of human embryonic lineage specification.
Li-Fang Chu   +9 more
semanticscholar   +1 more source

The endoderm: a divergent cell lineage with many commonalities

open access: yesDevelopment, 2019
The endoderm is a progenitor tissue that, in humans, gives rise to the majority of internal organs. Over the past few decades, genetic studies have identified many of the upstream signals specifying endoderm identity in different model systems, revealing
Sonja Nowotschin   +2 more
semanticscholar   +1 more source

A human ESC-based screen identifies a role for the translated lncRNA LINC00261 in pancreatic endocrine differentiation

open access: yeseLife, 2020
Long noncoding RNAs (lncRNAs) are a heterogenous group of RNAs, which can encode small proteins. The extent to which developmentally regulated lncRNAs are translated and whether the produced microproteins are relevant for human development is unknown ...
Bjoern Gaertner   +10 more
doaj   +1 more source

Corn root morphoanatomy at different development stages and yield under water stress [PDF]

open access: yesPesquisa Agropecuária Brasileira, 2016
: The objective of this work was to characterize the morphoanatomy of roots and the yield traits of two corn hybrids contrasting for drought tolerance (DKB 390, tolerant; and BRS 1030, sensitive), at different stages of development.
Thiago Corrêa de Souza   +4 more
doaj   +1 more source

A case report of craniovertebral junction intradural extramedullary neurenteric cyst

open access: yesMedical Journal of Dr. D.Y. Patil University, 2014
A neurenteric cyst of the craniocervical (CV) junction, as a cause of bulbomedullary compression, is very rare. An abnormal communication between the endoderm and neuroectoderm during the third week of embryogenesis may be responsible for its formation ...
Rajeshwari S Vhora   +3 more
doaj   +1 more source

Lumen Expansion Facilitates Epiblast-Primitive Endoderm Fate Specification during Mouse Blastocyst Formation

open access: yesDevelopmental Cell, 2019
Summary Epithelial tissues typically form lumina. In mammalian blastocysts, in which the first embryonic lumen forms, many studies have investigated how the cell lineages are specified through genetics and signaling, whereas potential roles of the fluid ...
A. Ryan   +3 more
semanticscholar   +1 more source

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