Results 41 to 50 of about 40,613 (248)
PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix
eLife, 2013 During embryonic development signalling pathways act repeatedly in different contexts to pattern the emerging germ layers. Understanding how these different responses are regulated is a central question for developmental biology.
S Nahuel Villegas +7 more
doaj +1 more source
Advanced Functional Materials, EarlyView.We present a tissue‐stimulator platform for seamless electrode integration with pancreatic tissue, applying uniform electrical stimulation through optimized design with biohybrid 3D printing. Advantageous effects of electrical stimulation on β‐cell function were observed, including enhanced calcium signaling, islet morphology, and maturation.
Jihwan Kim +7 more
wiley +1 more source
ELABELA Targets Mitochondria to Modulate Heart Development
Advanced Science, EarlyView.The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang +22 more
wiley +1 more source
İstanbul Medical Journal, 2018 Introduction: Human induced pluripotent stem cells (hiPSCs) have been recognized as key progenitor cells for liver regeneration, which could potentially be used in the repair of liver injury.
Nasim Parsafam +6 more
doaj +1 more source
In vitro Symbiosis of Reef-Building Coral Cells With Photosynthetic Dinoflagellates
Frontiers in Marine Science, 2021 Coral reefs are the biodiversity hot spots of the oceans, but they have suffered from increasing environmental stresses caused principally by anthropogenic global warming.
Kaz Kawamura +6 more
doaj +1 more source
Advanced Science, EarlyView.A developmentally inspired bioprinting approach enables the fabrication of pluripotent tissues that undergo shape‐morphing and in situ cardiac lineage specification. This method employs embedded bioprinting to deposit iPSCs within soft granular hydrogels to create pluripotent tissue constructs that undergo cell‐mediated shape morphogenesis.
Ankita Pramanick +8 more
wiley +1 more source
BMP signaling induces visceral endoderm differentiation of XEN cells and parietal endoderm
, 2012 The extraembryonic endoderm of mammals is essential for nutritive support of the fetus and patterning of the early embryo. Visceral and parietal endoderm are major subtypes of this lineage with the former exhibiting most, if not all, of the embryonic ...
Kunath, Tilo +13 more
core +1 more source
Vg1-Nodal heterodimers are the endogenous inducers of mesendoderm
eLife, 2017 Nodal is considered the key inducer of mesendoderm in vertebrate embryos and embryonic stem cells. Other TGF-beta-related signals, such as Vg1/Dvr1/Gdf3, have also been implicated in this process but their roles have been unclear or controversial.
Tessa G Montague, Alexander F Schier
doaj +1 more source
Advanced Science, EarlyView.In this article, Shuai and colleagues demonstrate that metabolic remodeling drives self‐diploidization in murine haploid ESCs (haESCs). Mitochondrial dysfunction and imbalanced pyruvate metabolism underlie this process. Genome‐wide screening using haESCs identifies key mitochondrial quality‐control related genes, enabling a metabolism‐based medium that
Yi Fu +11 more
wiley +1 more source
FEBS Open Bio, 2021 Thyroid dysgenesis (TD) is a major cause of primary congenital hypothyroidism; however, the molecular mechanism underlying this process is unclear.
Rui‐jia Zhang +6 more
doaj +1 more source