Results 31 to 40 of about 40,613 (248)

A desert lncRNA HIDEN regulates human endoderm differentiation via interacting with IMP1 and stabilizing FZD5 mRNA

Genome Biology, 2023
Background Extensive studies have revealed the function and mechanism of lncRNAs in development and differentiation, but the majority have focused on those lncRNAs adjacent to protein-coding genes.
Pei Lu, Jie Yang, Mao Li, Shanshan Wen, Tianzhe Zhang, Chenchao Yan, Ran Liu, Yu Xiao, Xinghuan Wang, Wei Jiang   +9 more
doaj   +1 more source

Dynamics of Drosophila endoderm specification

Proceedings of the National Academy of Sciences, 2022
Significance To understand developmental patterning of an organism, it is necessary to accurately measure how the state of a gene regulatory network is changing over time. One way of extracting dynamics of a network involves simultaneously imaging several reporters within fixed tissue.
Shannon E. Keenan, Maria Avdeeva, Liu Yang, Daniel S. Alber, Eric F. Wieschaus, Stanislav Y. Shvartsman   +5 more
openaire   +2 more sources

Genome-Wide Epigenetic Characterization of Tissues from Three Germ Layers Isolated from Sheep Fetuses

Frontiers in Genetics, 2017
DNA methylation of regulatory and growth-related genes contributes to fetal programming which is important for maintaining the correct development of three germ layers of the embryo that develope into different tissues and organs, and which persists into
Emanuele Capra, Paola Toschi, Marcello Del Corvo, Marcello Del Corvo, Barbara Lazzari, Barbara Lazzari, Pier A. Scapolo, Pasqualino Loi, John L. Williams, Alessandra Stella, Alessandra Stella, Paolo Ajmone-Marsan   +11 more
doaj   +1 more source

Notochord Patterning of the Endoderm

Developmental Biology, 2001
Endodermally derived organs of the gastrointestinal and respiratory system form at distinct anterioposterior and dorsoventral locations along the vertebrate body axis. This stereotyped program of organ formation depends on the correct patterning of the endodermal epithelium so that organ differentiation and morphogenesis occur at appropriate positions ...
Cleaver, Ondine, Krieg, Paul A
openaire   +2 more sources

Retinoic acid is required for endodermal pouch morphogenesis and not for pharyngeal endoderm specification [PDF]

Developmental Dynamics, 2006
AbstractLateral view of the head of a 30 hours post fertilization Tg(foxd3:gfp) zebrafish embryo expressing GFP in neural crest cells which will differentiate into pigment cells and cells in the pharyngeal arches (anterior is pointing up). The embryo is double labeled with the antibody Zn8 in red, which labels four endodermal pouches in between neural ...
Daniel, Kopinke, Joshua, Sasine, Jennifer, Swift, W Zac, Stephens, Tatjana, Piotrowski   +4 more
openaire   +2 more sources

Stem/progenitor cells in the developing human lung

Journal of Pediatric and Neonatal Individualized Medicine, 2016
Human lungs are composed of more than 40 cell types. The lung is classified as a “conditionally renewing” tissue and is able of a quick response to cellular damage thanks to the presence of multiple stem/progenitor cells.
Daniela Fanni, Margherita Fanos, Clara Gerosa, Flaviana Cau, Erika Pisu, Peter Van Eyken, Rossano Ambu   +6 more
doaj   +1 more source

Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis. [PDF]

PLoS ONE, 2009
BACKGROUND: Endoderm organ primordia become specified between gastrulation and gut tube folding in Amniotes. Although the requirement for RA signaling for the development of a few individual endoderm organs has been established a systematic assessment of
Elke Bayha, Mette C Jørgensen, Palle Serup, Anne Grapin-Botton   +3 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal [PDF]

, 2006
In Xenopus, the establishment of the anteroposterior axis involves two key signalling pathways, canonical Wnt and Nodal-related TGFbeta. There are also a number of transcription factors that feedback upon these pathways.
Gardner, Clare E, Clare E. Gardner, Geoffrey I. Johnston, Brickman, Joshua M, Andrea L. Zamparini, Tim Watts, Zamparini, Andrea L, Tomlinson, Simon R, Watts, Tim, Joshua M. Brickman, Johnston, Geoffrey I, Simon R. Tomlinson   +11 more
core   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source