Pluripotency factors regulate definitive endoderm specification through eomesodermin [PDF]
, 2011 Understanding the molecular mechanisms controlling early cell fate decisions in mammals is a major objective toward the development of robust methods for the differentiation of human pluripotent stem cells into clinically relevant cell types.
Matthew W.B. Trotter +17 more
core +3 more sources
The parietal endoderm and visceral endoderm were not affected in Cul4b-null embryos. [PDF]
, 2019 Cul4b+/Y and Cul4bΔ/Y embryos at E7.5 were sectioned and immunostained for GATA-4 (red), OCT-4 (green), and DAPI (blue). Dashed yellow lines indicate the cells with GATA-4 expression that are localized to regions of the parietal endoderm and visceral ...
Shu-Wha Lin (113879) +6 more
core +1 more source
Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal [PDF]
, 2006 In Xenopus, the establishment of the anteroposterior axis involves two key signalling pathways, canonical Wnt and Nodal-related TGFbeta. There are also a number of transcription factors that feedback upon these pathways.
Gardner, Clare E +11 more
core +1 more source
Stem cell engineering of the endoderm: approaches to controlling endoderm induction and differentiation from embryonic stem cells [PDF]
, 2008 Embryonic stem (ES) cell technology holds promise for curing innumerable human ailments. However, studies of the endoderm germ layer and its derivatives (liver, pancreas, and lung) are lacking.
Parashurama, Natesh
core +1 more source
Tukushi modulates Xnr2, FGF, and and BMP signalling: Regulation of Xenopus Germ Layer Formation [PDF]
, 2007 BACKGROUND: Cell-cell communication is essential in tissue patterning. In early amphibian development, mesoderm is formed in the blastula-stage embryo through inductive interactions in which vegetal cells act on overlying equatorial cells. Members of the
Ohta, K +4 more
core
Vertebrate development: Multiple phases to endoderm formation [PDF]
, 1999 Recent results support a two-step model for endoderm formation in amphibian embryos, in which endoderm is initially specified by localised maternal factors, including the transcription factor VegT, but is then maintained by extracellular signalling ...
Dale, Leslie, Leslie Dale
core +1 more source
Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration. [PDF]
, 2019 Migration of Anterior Visceral Endoderm (AVE) is a critical symmetry breaking event in the early post-implantation embryo development and is essential for establishing the correct body plan.
Orietti, Lorenzo Carlo +3 more
core +2 more sources
Endoderm patterning in Xenopus laevis [PDF]
, 2004 The endoderm is the inner germ layer of the vertebrate embryo from which the respiratory and digestive systems are derived. These include organs such as the liver, pancreas, stomach, lungs and intestine.
Costa, R
core
Vertebrate intestinal endoderm development [PDF]
Developmental Dynamics, 2011 AbstractThe endoderm gives rise to the lining of the esophagus, stomach and intestines, as well as associated organs. To generate a functional intestine, a series of highly orchestrated developmental processes must occur. In this review, we attempt to cover major events during intestinal development from gastrulation to birth, including endoderm ...
Jason R, Spence +2 more
openaire +2 more sources
Advanced Science, EarlyView.LRRK2‐mutant induced pluripotent stem cells (iPSCs) were derived from a patient with Parkinson's disease (PD). Using CRISPR/Cas9–mediated gene editing, the pathogenic LRRK2 mutations were precisely corrected, and isogenic dopaminergic neural progenitor cells (DA‐NPCs) were subsequently generated.
Qing Yan +29 more
wiley +1 more source