Results 21 to 30 of about 40,613 (248)

T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation

eLife, 2023
Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various biological processes, including embryonic development and cellular differentiation. Despite much progress over the past decade, the genome-wide annotation of lncRNAs remains
Alexandro Landshammer, Adriano Bolondi, Helene Kretzmer, Christian Much, René Buschow, Alina Rose, Hua-Jun Wu, Sebastian D Mackowiak, Bjoern Braendl, Pay Giesselmann, Rosaria Tornisiello, Krishna Mohan Parsi, Jack Huey, Thorsten Mielke, David Meierhofer, René Maehr, Denes Hnisz, Franziska Michor, John L Rinn, Alexander Meissner   +19 more
doaj   +1 more source

Investigating the molecular guts of endoderm formation using zebrafish [PDF]

, 2021
The vertebrate endoderm makes major contributions to the respiratory and gastrointestinal tracts and all associated organs. Zebrafish and humans share a high degree of genetic homology and strikingly similar endodermal organ systems.
Figiel, Daniela M., Elsayed, Randa, Nelson, Andrew   +2 more
core   +1 more source

Mature Mediastinal Teratoma [PDF]

Journal of Clinical and Diagnostic Research, 2015
A teratoma is a tumour with tissue or organ components resembling normal derivatives of more than one germ layer. We present a case of mediastinal mature teratoma as they have a low incidence rate.
Chikka Narasimhaiah Anushree, Vissa Shanti   +1 more
doaj   +1 more source

In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors

Cell Reports, 2017
T-box transcription factors T/Brachyury homolog A (Ta) and Tbx16 are essential for correct mesoderm development in zebrafish. The downstream transcriptional networks guiding their functional activities are poorly understood.
Andrew C. Nelson, Stephen J. Cutty, Saule N. Gasiunas, Isabella Deplae, Derek L. Stemple, Fiona C. Wardle   +5 more
doaj   +1 more source

In vitro generation of human pluripotent stem cell derived lung organoids

eLife, 2015
Recent breakthroughs in 3-dimensional (3D) organoid cultures for many organ systems have led to new physiologically complex in vitro models to study human development and disease.
Briana R Dye, David R Hill, Michael AH Ferguson, Yu-Hwai Tsai, Melinda S Nagy, Rachel Dyal, James M Wells, Christopher N Mayhew, Roy Nattiv, Ophir D Klein, Eric S White, Gail H Deutsch, Jason R Spence   +12 more
doaj   +1 more source

Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes

eLife, 2017
The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes – carotid body glomus cells, and ‘pulmonary neuroendocrine cells’ (PNECs) - are obscure.
Dorit Hockman, Alan J Burns, Gerhard Schlosser, Keith P Gates, Benjamin Jevans, Alessandro Mongera, Shannon Fisher, Gokhan Unlu, Ela W Knapik, Charles K Kaufman, Christian Mosimann, Leonard I Zon, Joseph J Lancman, P Duc S Dong, Heiko Lickert, Abigail S Tucker, Clare V H Baker   +16 more
doaj   +1 more source

Pharyngeal endoderm development

, 2023
AnnData object of scRNA-seq dataset of pharyngeal endoderm development data.
Michal Klein (9349343), Philipp Weiler (12855479), Marius Lange (9348875)   +2 more
core   +1 more source

Endoderm differentiation of tWT and dKO hESCs.

, 2022
A, A schematic drawing of the endoderm differentiation. B, Relative expression levels of representative genes during the endoderm differentiation. Box-plot elements are described in Fig 1. n = 7 from three different experiments.
Shota Nakanoh (9071402), An-Sofie Lenaerts (210471), Carola Maria Morell (14159951), Laetitia Pinte (10142636), Ludovic Vallier (75166), Juned Kadiwala (9071390)   +5 more
core   +1 more source

Mechanisms of endoderm formation in a cartilaginous fish reveal ancestral and homoplastic traits in jawed vertebrates

Biology Open, 2014
In order to gain insight into the impact of yolk increase on endoderm development, we have analyzed the mechanisms of endoderm formation in the catshark S. canicula, a species exhibiting telolecithal eggs and a distinct yolk sac.
Benoit G. Godard, Marion Coolen, Sophie Le Panse, Aurélie Gombault, Susana Ferreiro-Galve, Laurent Laguerre, Ronan Lagadec, Patrick Wincker, Julie Poulain, Corinne Da Silva, Shigehiro Kuraku, Wilfrid Carre, Agnès Boutet, Sylvie Mazan   +13 more
doaj   +1 more source

DIGIT Is a Conserved Long Noncoding RNA that Regulates GSC Expression to Control Definitive Endoderm Differentiation of Embryonic Stem Cells

Cell Reports, 2016
Long noncoding RNAs (lncRNAs) exhibit diverse functions, including regulation of development. Here, we combine genome-wide mapping of SMAD3 occupancy with expression analysis to identify lncRNAs induced by activin signaling during endoderm ...
Kaveh Daneshvar, Joshua V. Pondick, Byeong-Moo Kim, Chan Zhou, Samuel R. York, Jillian A. Macklin, Ameed Abualteen, Bo Tan, Alla A. Sigova, Chelsea Marcho, Kimberly D. Tremblay, Jesse Mager, Michael Y. Choi, Alan C. Mullen   +13 more
doaj   +1 more source