Results 21 to 30 of about 55,791 (279)
StemBook, 2008 In this chapter I focus on the emergence of endoderm, the origin of these cells and their organization in space. I also discuss the molecular events that lead to endoderm formation and how endoderm can be molecularly defined. Although the molecular control of endoderm formation has initially been deciphered using Xenopus, Zebrafish, sea urchin and ...
Grapin-Botton, Anne
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A novel method for generating induced pluripotent stem cell (iPSC)-derived alveolar organoids: a comparison of their ability depending on iPSC origin [PDF]
Organoid, 2023 Background Alveolar organoids may be useful tools in drug discovery for lung diseases, such as chronic obstructive pulmonary disease, and for studying the effects of respiratory viruses, such as severe acute respiratory syndrome coronavirus 2.
Min Jae Lim, Ayoung Jo, Sung-Won Kim
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Science, 2022 The mammalian blastocyst consists of three distinct cell types: epiblast, trophoblast (TB), and primitive endoderm (PrE). Although embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) retain the functional properties of epiblast and TB ...
Y. Ohinata +11 more
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Epithelial cell plasticity drives endoderm formation during gastrulation
Nature Cell Biology, 2021 It is generally accepted that epiblast cells ingress into the primitive streak by epithelial-to-mesenchymal transition (EMT) to give rise to the mesoderm; however, it is less clear how the endoderm acquires an epithelial fate.
Katharina Scheibner +13 more
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Cells, 2021 The endoderm, differentiated from human induced pluripotent stem cells (iPSCs), can differentiate into the small intestine and liver, which are vital for drug absorption and metabolism.
Shimeng Qiu +6 more
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Cell Reports, 2021 SUMMARY In addition to driving specific gene expression profiles, transcriptional regulators are becoming increasingly recognized for their capacity to modulate chromatin structure.
James A. Heslop +3 more
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Nature Communications, 2020 Visceral organs, such as the lungs, stomach and liver, are derived from the fetal foregut through a series of inductive interactions between the definitive endoderm (DE) and the surrounding splanchnic mesoderm (SM).
Lu Han +15 more
semanticscholar +1 more source
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation
Nature Cell Biology, 2020 Cooperation between DNA, RNA and protein regulates gene expression and controls differentiation through interactions that connect regions of nucleic acids and protein domains and through the assembly of biomolecular condensates.
K. Daneshvar +15 more
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T-REX17 is a transiently expressed non-coding RNA essential for human endoderm formation
eLife, 2023 Long non-coding RNAs (lncRNAs) have emerged as fundamental regulators in various biological processes, including embryonic development and cellular differentiation. Despite much progress over the past decade, the genome-wide annotation of lncRNAs remains
Alexandro Landshammer +19 more
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Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration [PDF]
, 2019 Migration of Anterior Visceral Endoderm (AVE) is a critical symmetry breaking event in the early post-implantation embryo development and is essential for establishing the correct body plan.
Orietti, Lorenzo Carlo +3 more
core +6 more sources