Results 61 to 70 of about 40,613 (248)

Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network

eLife, 2020
Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers.
Shreyasi Mukherjee, Praneet Chaturvedi, Scott A Rankin, Margaret B Fish, Marcin Wlizla, Kitt D Paraiso, Melissa MacDonald, Xiaoting Chen, Matthew T Weirauch, Ira L Blitz, Ken WY Cho, Aaron M Zorn   +11 more
doaj   +1 more source

Modern competency‐based teaching of human sexual development

Anatomical Sciences Education, EarlyView.
Abstract Embryology is an integral part of anatomy and a key subject in basic medical education. The development of the sexual tract, which is closely associated with the formation of the urinary tract and the organs of continence, is particularly complex and relevant for many medical disciplines.
Elisabeth Eppler, Alessandro Bilella, Christian M. Hammer   +2 more
wiley   +1 more source

Endoderm Generates Endothelial Cells during Liver Development

, 2014
Organogenesis requires expansion of the embryonic vascular plexus that migrates into developing organs through a process called angiogenesis. Mesodermal progenitors are thought to derive endothelial cells (ECs) that contribute to both embryonic ...
Uzan, Georges, Hamou, W., Goldman, O., Valerie Gouon-Evans, Uzan, G., Han, Songyan, Han, S., Jodon de Villeroche, V., Songyan Han, Lickert, H., Gouon-Evans, V., Goldman, Orit, Georges Uzan, Lickert, Heiko, Wissam Hamou, Vanina Jodon de Villeroche, Hamou, Wissam, Orit Goldman, Jodon de Villeroche, Vanina, Gouon-Evans, Valerie, Heiko Lickert   +20 more
core   +1 more source

Essential embryology for the Canadian pathologists’ assistant

Anatomical Sciences Education, EarlyView.
Abstract Pathologists' assistants (PAs) are pivotal in healthcare, conducting autopsies and examining tissues under a pathologist's guidance. Embryology knowledge is crucial for PAs to accurately assess anomalies and identify pathologies. Yet, it is often overlooked in academic PA training programs.
Samantha H. Nacci, William Tsui, Fang‐I Lu, Avrum I. Gotlieb, Danielle C. Bentley   +4 more
wiley   +1 more source

Pluripotency factors regulate definitive endoderm specification through eomesodermin

, 2011
Understanding the molecular mechanisms controlling early cell fate decisions in mammals is a major objective toward the development of robust methods for the differentiation of human pluripotent stem cells into clinically relevant cell types.
Matthew W.B. Trotter, Arnold, Sebastian J., Robertson, Elizabeth J., Adrian Kee Keong Teo, Chng, Zhenzhi, N. Ray Dunn, Stephanie Brown, Trotter, Matthew W. B., Lay Teng Ang, Ang, Lay Teng, Teo, Adrian Kee Keong, Brown, Stephanie, Dunn, N. Ray, Sebastian J. Arnold, Ludovic Vallier, Elizabeth J. Robertson, Vallier, Ludovic, Zhenzhi Chng   +17 more
core   +2 more sources

Human iPSC-Derived Posterior Gut Progenitors Are Expandable and Capable of Forming Gut and Liver Organoids

Stem Cell Reports, 2018
Summary: Early endoderm progenitors naturally possess robust propagating potential to develop a majority of meter-long gastrointestinal tracts and are therefore considered as a promising source for therapy.
Ran-Ran Zhang, Masaru Koido, Tomomi Tadokoro, Rie Ouchi, Tatsuya Matsuno, Yasuharu Ueno, Keisuke Sekine, Takanori Takebe, Hideki Taniguchi   +8 more
doaj   +1 more source

Spatiotemporal cellular dynamics of the notochord shape intervertebral disc morphogenesis in the mouse embryo through apoptosis and proliferation

Developmental Dynamics, EarlyView.
Abstract Background The notochord is a midline structure essential for vertebrate embryogenesis, contributing to the development of the nervous system, digestive tract, and vertebral column. In particular, notochord signaling is indispensable for proper patterning and coordinated development of alternating vertebrae and intervertebral discs (IVDs ...
Julie Warin, Estelle Balissat, Pauline Colombier, Lily Paillat, Maeva Dutilleul, Anne Camus   +5 more
wiley   +1 more source

Secretopathies emerge as a new class of neurocristopathies

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient embryonic population of cells that give rise to a wide range of structures, including craniofacial cartilage and bone, peripheral neurons and glia, as well as components of the cardiac outflow tract, among others.
Amanda Teixeira, Cassandra Millet‐Boureima, Joshua A. Moore, Loydie A. Jerome‐Majewska   +3 more
wiley   +1 more source

Zebrafish inversin mutants develop scoliosis in the absence of laterality defects

Developmental Dynamics, EarlyView.
Abstract Background Human mutations in INVERSIN are associated with nephronophthisis, variable penetrance of situs inversus and congenital heart disease. Inversin has been shown to localize to cilia and many of the patient phenotypes are attributed to disrupted cilia function.
Christopher J. Derrick, Lorraine Eley, Deborah J. Henderson, Bill Chaudhry   +3 more
wiley   +1 more source

The parietal endoderm and visceral endoderm were not affected in Cul4b-null embryos.

, 2019
Cul4b+/Y and Cul4bΔ/Y embryos at E7.5 were sectioned and immunostained for GATA-4 (red), OCT-4 (green), and DAPI (blue). Dashed yellow lines indicate the cells with GATA-4 expression that are localized to regions of the parietal endoderm and visceral ...
Shu-Wha Lin (113879), You-Tzung Chen (133378), Chen-Hsueh Pai (828204), I-Shing Yu (113877), Chun-Yu Chen (486495), Chien-Yu Lin (50716), Shu-Rung Lin (828206)   +6 more
core   +1 more source