Results 31 to 40 of about 69,462 (264)

A zebrafish embryo screen utilizing gastrulation identifies the HTR2C inhibitor pizotifen as a suppressor of EMT-mediated metastasis

open access: yeseLife, 2021
Metastasis is responsible for approximately 90% of cancer-associated mortality but few models exist that allow for rapid and effective screening of anti-metastasis drugs.
Joji Nakayama   +6 more
doaj   +1 more source

Dynamics of Sea Urchin Gastrulation Revealed by Tracking Cells of Diverse Lineage and Regulatory State [PDF]

open access: yes, 2011
During gastrulation in the sea urchin embryo the archenteron, or primitive gut, is formed by an initial process of invagination at the vegetal pole of the embryo, followed by extension across the blastocoel toward the future mouth.
Barnet, Matthew Edward
core   +1 more source

Molecular anatomy of the pre-primitive-streak chick embryo [PDF]

open access: yesOpen Biology, 2020
The early stages of development of the chick embryo, leading to primitive streak formation (the start of gastrulation), have received renewed attention recently, especially for studies of the mechanisms of large-scale cell movements and those that ...
Hyung Chul Lee   +6 more
doaj   +1 more source

A single-cell molecular map of mouse gastrulation and early organogenesis

open access: yesNature, 2019
Across the animal kingdom, gastrulation represents a key developmental event during which embryonic pluripotent cells diversify into lineage-specific precursors that will generate the adult organism. Here we report the transcriptional profiles of 116,312
Blanca Pijuan-Sala   +15 more
semanticscholar   +1 more source

Cell Polarity and Morphogenesis: Functions and Mechanisms of Cell Divisions in Vertebrate Gastrulation [PDF]

open access: yes, 2004
Gastrulation shapes a vertebrate embryo from an egg-shaped aggregate of cells. In many vertebrates, massive cell divisions occur during gastrulation. In this thesis, I investigate the pattern, function, and regulation of mitotic divisions in zebrafish ...
Gong, Ying, Ying Gong
core   +1 more source

Characterization of convergent thickening, a major convergence force producing morphogenic movement in amphibians

open access: yeseLife, 2022
The morphogenic process of convergent thickening (CT) was originally described as the mediolateral convergence and radial thickening of the explanted ventral involuting marginal zone (IMZ) of Xenopus gastrulae (Keller and Danilchik, 1988).
David R Shook   +9 more
doaj   +1 more source

Rab7 is required for mesoderm patterning and gastrulation in Xenopus

open access: yesBiology Open, 2021
Early embryogenesis requires tightly controlled temporal and spatial coordination of cellular behavior and signaling. Modulations are achieved at multiple levels, from cellular transcription to tissue-scale behavior.
Jennifer Kreis   +2 more
doaj   +1 more source

Quo vadis PGRMC? Grand-Scale Biology in Human Health and Disease

open access: yesFrontiers in Bioscience-Landmark, 2022
The title usage of Latin Quo vadis ‘where are you going’ extends the question Unde venisti from where ‘did you come?’ posed in the accompanying paper and extends consideration of how ancient eukaryotic and eumetazoan functions of progesterone receptor ...
Michael A. Cahill
doaj   +1 more source

Imaging in Spinal DysraphismA Pictoral Assay [PDF]

open access: yesInternational Journal of Anatomy Radiology and Surgery, 2021
Spinal dysraphism includes the congenital malformations of the spine and spinal cord. Spinal cord development takes place through successive stages of gastrulation, primary neurulation, and secondary neurulation. Defect in any of these three phases can
Anurudh Kishore Vatti   +2 more
doaj   +1 more source

The cessation of gastrulation [PDF]

open access: yesCell Adhesion & Migration, 2010
An integral component of gastrulation in all organisms is epithelial to mesenchymal transition (EMT), a fundamental morphogenetic event through which epithelial cells transform into mesenchymal cells. The mesenchymal cells that arise from epithelial cells during gastrulation contribute to various tissue rudiments during subsequent development ...
Sho, Ohta   +2 more
openaire   +2 more sources

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