The evolution of gastrulation morphologies [PDF]
Development, 2023 ABSTRACTDuring gastrulation, early embryos specify and reorganise the topology of their germ layers. Surprisingly, this fundamental and early process does not appear to be rigidly constrained by evolutionary pressures; instead, the morphology of gastrulation is highly variable throughout the animal kingdom.
Serrano Nájera, Guillermo +1 more
core +8 more sources
From genes to germ layers: virtual twins of gastruloids [PDF]
npj Systems Biology and ApplicationsHuman gastrulation remains a black box due to ethical and technical reasons. Human pluripotent stem cell-based 2D micropatterns and 3D organoids (gastruloids) recapitulate aspects of human gastrulation.
Leona M. Irwin +2 more
doaj +2 more sources
Actomyosin-based Self-organization of cell internalization during
BMC Biology, 2012 Background Gastrulation is a key transition in embryogenesis; it requires self-organized cellular coordination, which has to be both robust to allow efficient development and plastic to provide adaptability.
Pohl Christian +4 more
doaj +2 more sources
Random migration of induced pluripotent stem cell-derived human gastrulation-stage mesendoderm. [PDF]
PLoS ONE, 2018 Gastrulation is the initial systematic deformation of the embryo to form germ layers, which is characterized by the placement of appropriate cells in their destined locations.
Yuta Yamamoto +8 more
doaj +2 more sources
Adhesive Crosstalk in Gastrulation [PDF]
Developmental Cell, 2003 Recent studies show that signaling through integrin receptors is required for normal cell movements during Xenopus gastrulation. Integrins function in this process by modulating the activity of cadherin adhesion molecules within tissues undergoing convergence and extension movements.
Montero, J., Heisenberg, C.
openaire +4 more sources
Ectoderm tensile stress controls mesoderm internalization during embryo gastrulation [PDF]
Nature CommunicationsGastrulation is the dynamic reorganization of embryonic cells into a multi-stratified epithelial system from which inner and outer organs originate and a mature animal emerges. Tissue folding is one of the key morphogenetic processes driving gastrulation.
Abdul Basith Tanari +3 more
doaj +2 more sources
A Developmental Requirement for HIRA-Dependent H3.3 Deposition Revealed at Gastrulation in Xenopus
Cell Reports, 2012 Discovering how histone variants that mark distinct chromatin regions affect a developmental program is a major challenge in the epigenetics field. To assess the importance of the H3.3 histone variant and its dedicated histone chaperone HIRA, we used an ...
Emmanuelle Szenker +2 more
doaj +2 more sources
Conservation of cis-Regulatory Syntax Underlying Deuterostome Gastrulation [PDF]
CellsThroughout embryonic development, the shaping of the functional and morphological characteristics of embryos is orchestrated by an intricate interaction between transcription factors and cis-regulatory elements.
Lorena Buono +8 more
doaj +2 more sources
seqFish toy dataset of mouse gastrulation
, 2021 Highly multiplexed spatially resolved gene expression profiling of mouse organogenesis (aka spatial mouse gastrulation atlas ...
Elyas Heidari (11811722)
core +6 more sources
Cynomolgus Monkey (Macaca fascicularis) Embryo Models: From Developmental Benchmarks to Functionally Testable Embryoids. [PDF]
J Med PrimatolABSTRACT Stem cell‐based embryo models now reconstruct increasingly advanced stages of mammalian development, but developmental fidelity remains a central limitation. This review examines why cynomolgus monkey systems are biologically necessary, how natural embryos and emerging technologies benchmark primate development, and how advanced monkey ...
Jeong Y, Byun J, Moon SH, Kwon T.
europepmc +2 more sources