Results 11 to 20 of about 62,967 (236)
A single-embryo, single-cell time-resolved model for mouse gastrulation
Cell, 2021 Summary Mouse embryonic development is a canonical model system for studying mammalian cell fate acquisition. Recently, single-cell atlases comprehensively charted embryonic transcriptional landscapes, yet inference of the coordinated dynamics of cells ...
Saifeng Cheng +2 more
exaly +2 more sources
The evolution of gastrulation morphologies
Development, 2023 ABSTRACTDuring gastrulation, early embryos specify and reorganise the topology of their germ layers. Surprisingly, this fundamental and early process does not appear to be rigidly constrained by evolutionary pressures; instead, the morphology of gastrulation is highly variable throughout the animal kingdom.
Serrano Nájera, Guillermo +1 more
openaire +4 more sources
Spatial profiling of early primate gastrulation in utero
Nature, 2022 Gastrulation controls the emergence of cellular diversity and axis patterning in the early embryo. In mammals, this transformation is orchestrated by dynamic signalling centres at the interface of embryonic and extraembryonic tissues1–3.
Christopher A Penfold +2 more
exaly +2 more sources
Multi-omics profiling of mouse gastrulation at single-cell resolution
Nature, 2019 Formation of the three primary germ layers during gastrulation is an essential step in the establishment of the vertebrate body plan and is associated with major transcriptional changes1–5.
Ricard Argelaguet +2 more
exaly +2 more sources
Attachment of the blastoderm to the vitelline envelope affects gastrulation of insects
Nature, 2019 During gastrulation, physical forces reshape the simple embryonic tissue to form the complex body plans of multicellular organisms1. These forces often cause large-scale asymmetric movements of the embryonic tissue2,3.
Stefan Münster +2 more
exaly +2 more sources
Extracellular presentation of syntaxin4 as a potential trigger for region-specific gastrulation [PDF]
Cell Structure and FunctionDuring early embryogenesis, gastrulation occurs within a specific region of the pluripotent epiblast, where cells undergo significant changes in their context.
Sae Nozaki, Taisei Mihara, Yohei Hirai
doaj +2 more sources
Developmental Biology, 2021 During development, a single cell is transformed into a highly complex organism through progressive cell division, specification and rearrangement. An important prerequisite for the emergence of patterns within the developing organism is to establish asymmetries at various scales, ranging from individual cells to the entire embryo, eventually giving ...
Alexandra Schauer +1 more
openaire +2 more sources
Cell Stem Cell, 2023 Summary The emergence of the three germ layers and the lineage-specific precursor cells orchestrating organogenesis represent fundamental milestones during early embryonic development.
Bo Zeng +22 more
semanticscholar +1 more source
eLife, 2022 Screening for drugs that disrupt embryonic development in zebrafish can help identify treatments that suppress metastasis.
Chinyere Kemet, Emily Hill, Hui Feng
doaj +1 more source
Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs
Cell, 2022 Summary In vitro cultured stem cells with distinct developmental capacities can contribute to embryonic or extraembryonic tissues after microinjection into pre-implantation mammalian embryos.
Shadi Tarazi +23 more
semanticscholar +1 more source