Results 101 to 110 of about 2,062,237 (252)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Nociception and pain assessment during suctioning procedures in mechanically ventilated patients in the intensive care unit: A validation study of the Nociception Level index (NOL™)

Canadian Journal of Pain
Background Many patients in the intensive care unit (ICU) cannot communicate pain through self-reports or behaviors. Though individual physiologic parameters (e.g.
Shiva Shahiri, Philippe Richebé, Marc O. Martel, Patrick Lavoie, Céline Gélinas   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Higher d Eisenstein series and a duality-invariant distance measure

Journal of High Energy Physics
The Petersson inner product is a natural inner product on the space of modular invariant functions. We derive a formula, written as a convergent sum over elementary functions, for the inner product E s (G, B) of the real analytic Eisenstein series $${E}_{
Nathan Benjamin, A. Liam Fitzpatrick
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

PR-10 DEP Replacement Procedure

, 2013
A Disability Equipment Program procedure covering replacement. The target audience is Approved Prescribers and Aged and Disability Program Staff.
Department of Health
core  

The mating systems of pinnipeds and marine iguanas: convergent evolution of polygyny [PDF]

, 1984
Trillmich F, Trillmich KGK. The mating systems of pinnipeds and marine iguanas: convergent evolution of polygyny. Biological Journal of the Linnean Society.
Trillmich, Fritz ; https://orcid.org/, Trillmich, Krisztina G. K.   +1 more
core  

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

European Union broadcasting and telecoms: towards a convergent regulatory regime?

, 1999
After placing the development of EU broadcasting and telecommunications policy into its historical context, the article argues that the EU, having traditionally found it difficult to develop a regulatory regime concerning content and culture, has ...
Michalis, M.
core   +1 more source

The Convergent Atrial Fibrillation Ablation Procedure: Evolution of a Multidisciplinary Approach to Atrial Fibrillation Management

Arrhythmia & Electrophysiology Review, 2020
Karan Wats, Andy Kiser, Kevin Makati, Nitesh Sood, David DeLurgio, Yisachar Greenberg, Felix Yang   +6 more
doaj   +1 more source