Results 111 to 120 of about 2,062,237 (252)
Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk
Molecular Oncology, EarlyView.Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley +1 more source
Convergent Validity of Contingent Behavior Responses in Models of Recreation Demand [PDF]
Recreation demand modeling efforts are often limited by the range of variation in observed environmental quality. To address this limitation, the practitioners increasingly makes use of contingent behavior (CB) data; i.e., asking survey respondents to ...
Jeon, Yongsik, Herriges, Joseph A.
core
Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source
Escape from the peak procedure [PDF]
, 2014 The peak procedure is a timing procedure used to measure the ability of animals to time intervals. The peak procedure consists of fixed interval (FI) trials and some non-reinforced or extinction trials (EXT).
Juekarun, Phloiuma
core
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
PR-5 DEP Client Contribution Procedure
, 2013 A Disability Equipment Program procedure covering client contribution. The target audience is Approved Prescribers and Aged and Disability Program Staff.
Department of Health
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
PR-9 DEP Triage and Repair Procedure
, 2013 A Disability Equipment Program procedure covering triage and repair. The target audience is Approved Prescribers and Aged and Disability Program Staff.
Department of Health
core
Procedure-related outcomes and overall complication rates.
, 2018 Procedure-related outcomes and overall complication rates.
Vincent J. Obias (5892818) +12 more
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source