Results 91 to 100 of about 365,980 (259)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Malingering and functional movement disorder

Неврология, нейропсихиатрия, психосоматика
Functional movement disorders (FMD) are frequently encountered in the clinical practice of neurologists. Recently, the interest of specialists in FMD has increased. Based on neuroimaging, neurophysiological and neuropsychological studies, concepts of the
K. M. Evdokimov, E. Yu. Fedotova, S. N. Illarioshkin   +2 more
doaj   +1 more source

Electro-Magnetic Earthquake Bursts and Critical Rupture of Peroxy Bond Networks in Rocks

, 2006
We propose a mechanism for the low frequency electromagnetic emissions and other electromagnetic phenomena which have been associated with earthquakes. The mechanism combines the critical earthquake concept and the concept of crust acting as a charging ...
Allègre, Alperovich, Andersen, Andersen, Anifrani, Ashby, Bak, Bell, Bianchi, Bouchaud, Bowman, Bowman, Bowman, Bowman, Brehm, Brehm, Bufe, Bufe, Chen, Cliverd, Contoyiannis, D. Sornette, Debate on VAN (special issue), Derr, Dey, Dickinson, Dieterich, Edwards, Eftaxias, Eftaxias, Ellsworth, F. Freund, Freund, Freund, Freund, Freund, Freund, Freund, Freund, Freund, Freund, Freund, Freund, Freund, Freund, Frid, Friebele, Frost, Fujinawa, Fujinawa, Garcimartin, Gershenzon, Gokhberg, Hayakawa, Heimpel, Helmstetter, Hickman, Huang, Huang, Ivanov, Jaumé, Johansen, Johansen, Johnston, Jones, Jones, Kagan, Kapiris, Kapiris, Kathrein, Keilis-Borok, Keilis-Borok, Keilis-Borok, King, King, King, Knopoff, Kopytenko, Kossobokov, Lei, Lei, Lei, Levin, Lindh, Liu, Liu, Ma, Main, Martelli, Martens, Martin, Mogi, Molchanov, Molchanov, Molchanov, Mora, Moura, Moura, Moura, Naaman, NASDA-CON-960003, Nechad, Nechad, Nitsan, Ohta, Ondoh, Ouillon, Ouillon, Ouzounov, Park, Place, Pulinets, Pulinets, Pulinets, Qiang, Rabinovitch, Raleigh, Regenauer-Lieb, Ricci, Rossman, Roux, Sahimi, Saleur, Sammis, Sammis, Shamir, Smyth, Sornette, Sornette, Sornette, Sornette, Sornette, Sornette, Sornette, Sornette, Sornette, Sornette, Sorokin, Srivastav, St-Laurent, Stauffer, Sykes, Taylor, Tocher, Trigunait, Tronin, Tronin, Tsukuda, Varotsos, Vere-Jones, Vershinin, Wilson, Yasui, Yen, Yoshida, Yoshino, Yukalov, Zhuang, Zlotnicki   +158 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Locus coeruleus co‐activation patterns at rest show higher state persistence in patients with dissociative seizures: A Pilot Study

Epilepsia Open
Objective Dissociative seizures are paroxysmal disruptions of awareness and behavioral control in the context of affective arousal. Alterations in stress‐related endocrine function have been demonstrated, but the timescale of dissociation suggests that ...
Samantha Weber, Johannes Jungilligens, Selma Aybek, Stoyan Popkirov   +3 more
doaj   +1 more source

Somatization and Conversion Disorder [PDF]

The Canadian Journal of Psychiatry, 2004
Somatization is the psychological mechanism whereby psychological distress is expressed in the form of physical symptoms. The psychological distress in somatization is most commonly caused by a mood disorder that threatens mental stability. Conversion disorder occurs when the somatic presentation involves any aspect of the central nervous system over ...
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source