Results 111 to 120 of about 2,151,814 (254)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Response inhibition in motor conversion disorder

open access: yes, 2013
Conversion disorders (CDs) are unexplained neurological symptoms presumed to be related to a psychological issue. Studies focusing on conversion paralysis have suggested potential impairments in motor initiation or execution.
Voon, V.   +20 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Attention-deficit/hyperactivity disorder: a closer look [PDF]

open access: yes, 1999
Plan BThis paper examines Attention-Deficit Hyperactivity Disorder. More specifically, the aim of this paper is to discuss some of the many operational definitions of ADHD.
O'Neill, Michael J.
core  

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Abreaction for conversion disorder: systematic review with meta-analysis

open access: yes, 2010
Background The value of drug interviews in the treatment of conversion disorder is at present unknown. Aims To review all the available papers published in English that report on the use of drug interviews for treating conversion/dissociative disorder ...

core   +1 more source

Paradoxical therapy in conversion disorder

open access: yes, 1998
Paradoxical therapy consists of suggesting that the patient intentionally engages in the unwanted behaviour, such as performing complusive ritual or bringing on a conversion attack.
Ataoğlu, Ahmet   +2 more
core   +1 more source

Methylome changes associated with functional movement/conversion disorder: Influence of biological sex and childhood abuse exposure. [PDF]

open access: yesProg Neuropsychopharmacol Biol Psychiatry, 2023
Spagnolo PA   +4 more
europepmc   +1 more source

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