Results 71 to 80 of about 31,866 (253)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
The The Effect of Tramadol Addiction on Convulsion and Related Factors
, 2020 Background: Tramadol is a drug used to control severe pain. Various side effects of this drug have been reported, one of the most important is seizures. The exact cause of tramadol-induced seizures is not known.
Zolfaghari 3, Pouneh +5 more
core +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Studies on the Interception of the Pathways of Epileptic Convulsion Part I. Demaging the Pathways of Epileptic Convulsion with the Horsley-Clarke's Stereotaxic Apparatus [PDF]
, 1959 In order to clarifing the pathways of epileptic convulsion, the following experiments were performed by the author. The same fieldes in the diencephalon of the cat were selectively damaged with the Horsley-Clarke's stereotaxic apparatus, and I-3 weeks ...
Kanbayashi, Tsuneo
core
Decreased NK cell count is a high-risk factor for convulsion in children with COVID-19
, 2023 Background The neurological symptoms caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are of increasing concern. Convulsions are among the main neurological manifestations reported in children with coronavirus disease-2019 (COVID-19)
Xiaohong Li +8 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Parental Anxiety Levels of Patients Admitted to Pediatric Emergency Clinic Due to Febrile Convulsion
, 2020 Aim: This study aims to determine the anxiety levels of the parents of patients admitted to the pediatric emergency clinic due to febrile convulsion, and to evaluate factors that may affect anxiety levels.
Necati Uzun +4 more
core +2 more sources
PARENTAL KNOWLEDGE, ATTITUDE AND PRACTICES REGARDING FEBRILE CONVULSION IN TABUK CITY, SAUDI ARABIA
, 2021 Background: Febrile convulsion is a common condition can traumatize the parents. Its a benign convulsive disorder in children under 5-year-old. In our study we assess the level of parent’s knowledge, attitude and practices regarding febrile convulsion ...
Abdullah Ismail Alsharif , Sarah Mohammed Alzahrani
core +1 more source