Results 41 to 50 of about 379,003 (248)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Canadian Broadcasting Policy, Capitalism, and CanCon

Canadian Journal for the Academic Mind
In April of 2023, Bill C-11, the Online Streaming Act, was given Royal Assent to amend Canada’s 1991 Broadcasting Act to regulate transnational, American-based online streaming services that lack intrinsic reason to enhance and foster conceptions of a ...
Christine Rose Cooling
doaj   +1 more source

Dynamics model for the thermal performance from a lyophilization process, based on a complete transfer functions matrix

Revista de Ciencias Tecnológicas, 2020
During the beginning of the XX century lyophilization was developed as an alternative technology to extend the storage time for fruit and vegetables or other kind of food; however, the energetic consumption of this technology makes it not an option for ...
Maria Elizabeth Rodríguez- Ibarra, Eloy Edmundo Rodríguez Vázquez, Ana Marell Arteaga-Martínez, Samantha Lilia Narváez-Granados, Helen Janeth Zuñiga-Osorio, Victor Miguel Villasana-Velázquez   +5 more
doaj   +1 more source

A New Alternate Method to Reuse Rehashed Edible Oil for the Betterment of Society - Dual Benefit Approach in Photovoltaic Modules

IEEE Access, 2021
The Photovoltaic (PV) cell converts a portion of incident irradiation of visible wavelength into electricity and the remaining into heat, thereby decreasing the electrical efficiency. Hence, it is necessary to transfer the heat generated in the module by
Prince Winston David, Karthikeyan Ganesan, Palpandian Murugesan, Pravin Murugesan, Ganesan Jeyakodi, Praveen Kumar Balachandran, Santhan Kumar Cherukuri, Thanikanti Sudhakar Babu, Hassan Haes Alhelou   +8 more
doaj   +1 more source

Where Do Cooling Flows Cool? [PDF]

The Astrophysical Journal, 2000
18 pages with 6 figures; accepted by Astrophysical ...
Brighenti, Fabrizio, Mathews, William G.
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Electromagnetic thermal coupling analysis for a novel cooling system of an axial flux hub motor

IET Electric Power Applications, 2022
In this paper, a novel cooling system of the yokeless and segmented armature axial flux machine (YASA) applied in‐wheel traction is presented.
Jiujian Chang, Chen Wang
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source