Results 21 to 30 of about 1,164,350 (247)

Active cool roof effect: impact of cool roofs on cooling system efficiency

Advances in Building Energy Research, 2013
Cool roofs represent an acknowledged, relatively simple, and low-cost strategy to reduce cooling energy demand of buildings and mitigate urban heat island phenomena. The purpose of this paper is to study the coupled passive–active effect produced by such a technology, where the active effect consists of the cool roof capability to decrease the suction ...
PISELLO, ANNA LAURA, Santamouris, Mattheos, COTANA, Franco   +2 more
openaire   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Comparison of climate and production in closed, semi-closed and open greenhouses [PDF]

, 2011
A (semi-)closed greenhouse is a novel greenhouse with an active cooling system and temporary heat storage in an aquifer. Air is cooled, heated and dehumidified by air treatment units. Climate in (semi-)closed greenhouses differs from that of conventional
Dieleman, J.A., Elings, A., Gelder, A., de, Kooten, O., van, Marcelis, L.F.M., Qian, T.   +5 more
core   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Instanton size distributions from calibrated cooling

, 1994
Using an under-relaxed cooling algorithm we investigated the vacuum in the $2d\ O(3)$ model and $4d$ pure gauge $SU(2)$. We calibrated the amount of cooling performed to have similar physical effect at different lattice spacings.Comment: 3 pages, (Talk ...
C. Michael, Lüscher, P.S. Spencer, Rajaraman   +3 more
core   +2 more sources

Sympathetic Cooling of Mixed Species Two-Ion Crystals for Precision Spectroscopy [PDF]

, 2012
Sympathetic cooling of trapped ions has become an indispensable tool for quantum information processing and precision spectroscopy. In the simplest situation a single Doppler-cooled ion sympathetically cools another ion which typically has a different ...
D. J. Wineland, D. Leibrandt, F. Riehle, G. J. Dick, Jannes B. Wübbena, L. Landau, Olaf Mandel, P. Ghosh, Piet O. Schmidt, Sana Amairi, T. Rosenband   +10 more
core   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Galaxy Formation with local photoionisation feedback I. Methods [PDF]

, 2013
We present a first study of the effect of local photoionising radiation on gas cooling in smoothed particle hydrodynamics simulations of galaxy formation. We explore the combined effect of ionising radiation from young and old stellar populations.
Cantalupo, S., Christensen, C., Hennawi, J. F., Kannan, R., Macciò, A. V., Quinn, T. R., Robitaille, T., Shen, S., Stinson, G. S., Wadsley, J., Woods, R.   +10 more
core   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source