Results 41 to 50 of about 1,106,018 (303)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Microstructure Refinement on Crevice Corrosion of High-Speed Rail Steel U75V Visualized by an In Situ Monitoring System

Frontiers in Materials, 2022
Rail foot covered by a fastener will suffer from crevice corrosion, leading to thinning and localized attack of crevice interior posing a risk of failure. This work investigated crevice corrosion behavior of a typical pearlitic high-speed rail steel U75V,
Jian Wang, Jian Wang, Jian Wang, Binbin Zhang, Binbin Zhang, Binbin Zhang, Weichen Xu, Weichen Xu, Weichen Xu, Jie Zhang, Jie Zhang, Jie Zhang, Lihui Yang, Lihui Yang, Lihui Yang, Zhongbo Peng, Baorong Hou, Baorong Hou, Baorong Hou   +18 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Cooling mechanical resonators to quantum ground state from room temperature

, 2014
Ground-state cooling of mesoscopic mechanical resonators is a fundamental requirement for test of quantum theory and for implementation of quantum information. We analyze the cavity optomechanical cooling limits in the intermediate coupling regime, where
Dong, Chun-Hua, Gong, Qihuang, Li, Yan, Liu, Rui-Shan, Liu, Yong-Chun, Xiao, Yun-Feng   +5 more
core   +1 more source

Efficient sympathetic motional ground-state cooling of a molecular ion [PDF]

, 2015
Cold molecular ions are promising candidates in various fields ranging from precision spectroscopy and test of fundamental physics to ultra-cold chemistry.
Gebert, Florian, Schmidt, Piet O., Wan, Yong, Wolf, Fabian   +3 more
core   +3 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Effect of cooling medium temperature on cooling curve and microstructure of Ti65 alloy

Cailiao gongcheng
The cooling rate after high-temperature heat treatment has a significant effect on the microstructure and properties of Ti65 alloy. The effect of cooling medium temperature on the cooling curve and microstructure of Ti65 alloy after high-temperature heat
DONG Xiaolin, LI Wenyuan, TAN Haibing, LIU Jianrong, LIU Qiaomu, CHEN Yulong, WANG Lei, WANG Qingjiang   +7 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Occurrence of Hysteresis like behavior of resistance of $Sb_2 Te_3$ film in heating-cooling cycle

, 2004
Experimental observations of a peculiar behavior observed on heating and cooling ${\rm Sb_2Te_3}$ films at different heating and cooling rate are detailed. The film regained its original resistance, forming a closed loop, on the completion of the heating-
A.G. Vedeshwar, Arun, Arun, Arun, Carslaw, Damodara Das, Damodara Das, Damodara Das, Jayachandran, Lefebvre, Maissel, P. Arun, Pankaj Tyagi, Sakamoto, Sze   +14 more
core   +1 more source

Rate of Cooling in a Moose (Alces alces) Carcass [PDF]

Journal of Wildlife Diseases, 2019
Postmortem body temperature is used to estimate time of death in humans, but the available models are not validated for most nonhuman species. Here, we report that cooling in an adult female moose (Alces alces) equipped with a rumen temperature monitor was extremely slow, with a rumen temperature of 27-28 C as late as 40 h postmortem.
Evans, Alina L., Fuchs, Boris, Græsli, Anne Randi, Neumann, Wiebke, Stenbacka, Fredrik, Singh, Navinder J., Ericsson, Göran, Malmsten, Jonas, Arnemo, Jon Martin   +8 more
openaire   +3 more sources