Results 41 to 50 of about 259,615 (264)

Effect of Roll Material on Strip Solidification between the Rolls of a Vertical-Type High-Speed Twin-Roll Caster

open access: yesMetals, 2022
Tool steel for hot working is usually used for the rolls of conventional twin-roll casters for aluminum alloys. In a vertical high-speed twin-roll caster, copper rolls are used to rapidly solidify the aluminum alloys and to increase the casting speed ...
Toshio Haga, Yukihiro Kurahashi
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

The effect of sintering and cooling process on geometry distortion and mechanical properties transition of PTFE/Al reactive materials

open access: yesDefence Technology, 2020
In this research, the effect of the sintering and cooling process on geometry distortion and mechanical properties of PTFE/Al reactive material is investigated.
Hai-fu Wang   +5 more
doaj   +1 more source

Precipitation behavior of γ′ phase in P/M superalloy Udimet720Li

open access: yesFenmo yejin jishu, 2021
P/M superalloy Udimet720Li specimens were solutioned and quenched at the different cooling rates in gas quenching furnace, following by the double aging treatment. The microstructures and elevated temperature tensile properties at 650 ℃ were investigated,
LIU Jian   +4 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

open access: yesFEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Effect of Spray Parameters on Vacuum Cooling of Tofu

open access: yesZhileng xuebao, 2021
More and more attention is paid to vacuum spray cooling (VSC) because it can effectively reduce the water loss rate in the process of food vacuum cooling.
Peng Yuhang   +6 more
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

open access: yesFEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata   +13 more
wiley   +1 more source

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