Results 51 to 60 of about 5,537,146 (196)

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Effect of Spray Parameters on Vacuum Cooling of Tofu

Zhileng xuebao, 2021
More and more attention is paid to vacuum spray cooling (VSC) because it can effectively reduce the water loss rate in the process of food vacuum cooling.
Peng Yuhang, Du Shuaihua, Jin Tingxiang, Chen Hua, Wei Yao, Huang Yu, Zhang Pan   +6 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

The Impact of EMS on the Temperature Fluctuations, Appearance, and Microstructure of GTA Stainless Steel Welds

Metals, 2020
The purpose of this study was to evaluate the temperature fluctuation induced by electromagnetic stirring (EMS) and to investigate the influence of temperature fluctuation on the appearance and microstructure of the stainless steel welds.
Sheng-Long Jeng, Dai-Ping Su, Jing-Ting Lee, Jiunn-Yuan Huang   +3 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Continuous Cooling Transformation and Structure Refinement of A Low Carbon High Strength Steel Produced by FTSR

Teshugang, 2009
Continuous cooling transformation(CCT) and structure of 85 mm FTSR(Flexible Thin Slab rolling) cast slab ofa low carbon steel(%:0.19C,1.15Mn,0.008Mo,0.002Ti,0.032Als)deformed 40% with stain rate 5 s-1 at 1000 ℃ then cooling with 5℃/s to 900 ℃ and ...
高爱民, 杨琨, 冯运莉, 陈礼斌
doaj  

Effects of continuous cooling and isothermal cooling parameters on microstructure and mechanical properties of EH420 marine steel

Journal of Materials Research and Technology
This study aims to investigate the effects of continuous cooling after deformation at 900 °C and isothermal cooling after deformation at 830 °C on the microstructure and mechanical properties of EH420 steel, emphasizing ferrite structure evolution.
Hui Liu, Zhiqiang Wu, Guili Xu, Junhong Yu, Daheng Xiao, Wenhao Zhou, Biao Deng, Xuhui Liu, Jun Hu   +8 more
doaj   +1 more source