Results 51 to 60 of about 1,106,018 (303)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Laser cooling with a modified optical shaker

, 2009
Some practical improvements are proposed for the "optical-shaker" laser-cooling technique [I.S. Averbukh and Y. Prior, Phys. Rev. Lett. 94, 153002 (2005)].
Marmet, Louis
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The effect of sintering and cooling process on geometry distortion and mechanical properties transition of PTFE/Al reactive materials

Defence Technology, 2020
In this research, the effect of the sintering and cooling process on geometry distortion and mechanical properties of PTFE/Al reactive material is investigated.
Hai-fu Wang, Bao-qun Geng, Huan-guo Guo, Yuan-feng Zheng, Qing-bo Yu, Chao Ge   +5 more
doaj   +1 more source

Time-Dependence of the Mass Accretion Rate in Cluster Cooling Flows [PDF]

, 2000
We analyze two time-dependent cluster cooling flow models in spherical symmetry. The first assumes that the intracluster gas resides in a static external potential, and includes the effects of optically thin radiative cooling and mass deposition.
Bailey M. E., Chevalier R. A., Craig L. Sarazin, Eric A. Lufkin, McGlynn T. A., Meiksin A., Raymond E. White III, Thomas P. A., White D. A.   +8 more
core   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Effect of Roll Material on Strip Solidification between the Rolls of a Vertical-Type High-Speed Twin-Roll Caster

Metals, 2022
Tool steel for hot working is usually used for the rolls of conventional twin-roll casters for aluminum alloys. In a vertical high-speed twin-roll caster, copper rolls are used to rapidly solidify the aluminum alloys and to increase the casting speed ...
Toshio Haga, Yukihiro Kurahashi
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Simulations of Jet Heating in Galaxy Clusters: Successes and Challenges

, 2018
We study how jets driven by active galactic nuclei influence the cooling flow in Perseus-like galaxy cluster cores with idealised, non-relativistic, hydrodynamical simulations performed with the Eulerian code ATHENA using high-resolution Godunov methods ...
Faucher-Giguere, Claude-Andre, Fielding, Drummond, Martizzi, Davide, Quataert, Eliot   +3 more
core   +1 more source

THE RATE OF COOLING OF SEVERAL POULTICE MASSES [PDF]

Journal of the American Medical Association, 1909
The value of poultices for most purposes being proportional to their retention of heat, it appeared desirable to compare the rate of cooling of several poultice masses. A comparison of the easily prepared linseed poultice and the official clay poultice, cataplasma kaolini, seemed particularly desirable and these were controlled most carefully ...
openaire   +2 more sources