Results 71 to 80 of about 5,537,146 (196)

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

The impact of a register on the management of neonatal cooling in Switzerland. [PDF]

, 2015
BACKGROUND Therapeutic hypothermia following hypoxic ischaemic encephalopathy in term infants was introduced into Switzerland in 2005. Initial documentation of perinatal and resuscitation details was poor and neuromonitoring insufficient.
Tolsa, J-F, Wellmann, S, Bucher, H.U., Latal, B., Ramos, G., Birkenmayer, A., Daetwyler, K., Grass, B., Wellmann, S., Birkenmayer, A, Pfister, R E, Tolsa, J.F., Fontana, M, Hagmann, C., Bernet, V., Bernet, V, Wagner, Bendicht Peter, Latal, B, Berger, T.M., Bucher, H U, Nelle, M, Scharrer, B., Hagmann, Cornelia; https://orcid.org/, Natalucci, G, Nelle, Mathias, Bär, W., Wagner, B., Brotschi, B., Zeilinger, G., Micallef, J.P., Scharrer, B, Held, Ulrike, Meyer, Ph, Truttmann, A, Held, U., Hagmann, Cornelia, Schneider, J, Beck, I., Grass, Beate, Natalucci, G., Fontana, M., Pfister, R.E., Beck, Ingrid, Schulzke, S.M., Natalucci, Giancarlo; https://orcid.org/, Schulzke, S M, Adams, M., Adams, M, Nelle, M., Pfister, Riccardo, Schneider, J., Daetwyler, K, Micallef, J P, Frey, B, Ramos, Gabriel, Zeilinger, G, Frey, B., Brotschi, Barbara, Truttmann, A., Bär, W, Meyer, P., Berger, T M, Latal, B; https://orcid.org/, Wagner, B   +63 more
core   +1 more source

Monitoring body temperature during moderate intensity exercise and inactive recovery in the cold

Current Issues in Sport Science, 2019
Exposure to cold ambient conditions during outdoor recreation can lead to significant heat loss. It is unknown how fast body temperature decreases or how fast a person could become hypothermic in cold temperatures.
Emily Procter, Giacomo Strapazzon, Hannes Gatterer, Bernd Wallner, Hermann Brugger, Martin Burtscher   +5 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Improvement of summer comfort by passive cooling with increased ventilation and night cooling [PDF]

, 2013
The study describes the potential improvement of summer comfort and reduction of energy consumption that can be achieved by adopting passive cooling solutions, such as daytime comfort ventilation with increased air velocities and night cooling, in ...
Pellegrini, Tommaso
core  

Rapid Cooling and Solidification Microstructure of Argon Atomized Ti-48Al Alloy Droplets

Cailiao gongcheng, 2018
An analytical approach was developed to investigate nucleation and growth of Ti-48Al (atom fraction/%) alloy droplets during their flight in an argon atomization process.
BAO Ying, LUO Lin, YU Ze-min, YANG Dong-ye, LIU Na, ZHANG Guo-qing, SUN Jian-fei   +6 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

Microstructure Evolution of Sn-35Bi-1Ag/Ni-P/Cu Solder Joints During Post-reflow Cooling and Isothermal Aging

Cailiao gongcheng, 2018
Two kinds of rapid and slow cooling solder joints of Sn-35Bi-1Ag/Ni-P/Cu were prepared by reflow soldering and then cooling in water and oven, respectively. The kinetics of two kinds of layers were investigated using isothermal aging.
LU Han-qiao, LI Yu-long, YU Xiao, LONG Wei-feng, JIANG Jian-feng   +4 more
doaj   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source