Results 101 to 110 of about 1,085,552 (317)

DNA oligomer binding in competition exhibits cooperativity

New Journal of Physics, 2019
Binding of two complementary DNA single strands to a double-helix, DNA hybridization, is a sequence specific molecular recognition process that plays important roles in biology and biotechnological applications.
Mina Mohammadi-Kambs, Albrecht Ott
doaj   +1 more source

Deception as cooperation

Studies in History and Philosophy of Science Part C: Studies in History and Philosophy of Biological and Biomedical Sciences, 2019
Data from my 'Deception as Cooperation ...
openaire   +3 more sources

Common Ground: Why Should University Faculty Partner with Virginia Cooperative Extension?

, 2014
The Virginia Beginning Farmer and Rancher Coalition Program (VBFRCP) is a collaborative effort through Virginia Cooperative Extension and Virginia Tech that reaches across the commonwealth to provide educational opportunities for beginning farmers and ...
Niewolny, Kimberly L., Gehrt, Karen Roth
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Virginia Cooperative Extension - By the Numbers

, 2016
Provides statistics on the activities of Virginia Cooperative Extension and the Virginia Agricultural Experiment Station, including funding, extension and research effort, 4-H programs, and volunteer participation in VCE ...

core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Landscape plants

, 1985
Presents information on a variety of landscaping plants, trees and ...
Virginia Cooperative Extension Service
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Being prepared

, 2003
prepared by Robert H. Flashman, Celia Ray Hayhoe, and Alex Lesueur, Jr.Reprinted 2003A joint publication of the Kentucky Cooperative Extension Service and Virginia Cooperative ...
Flashman, Robert H., Lesueur, Alex, Hayhoe, Celia Ray   +2 more
core