Results 81 to 90 of about 872,356 (317)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Virginia Cooperative Extension Peer Reviewer Feedback Form

, 2016
This document provides guidelines for reviewing quality and accuracy of text, and illustrations in manuscripts under consideration for publication by Virginia Cooperative ...

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2021 Home Grounds and Animals PMG - Index

, 2021
This is a chapter of the 2021 Field Crops PMG. The Virginia Pest Management Guide (PMG) series lists options for management of major pests: diseases, insects, nematodes, and weeds.
Langston, David B., Day, Eric R., Chandran, Rakesh, VanGessel, Mark, Singh, Vijay, Currin, John F., Hines, Tommy, Taylor, Sally V., Vollmer, Kurt, Wilson, James, Balota, Maria, Lingenfelter, Dwight, Johnson, Quintin, Laub, Curt, Besancon, Thierry E., Jordan, David, McCoy, Tim, Herbert, Ames Jr., Frame, W. Hunter, Johnson, Charles S., Koehler, Alyssa, Frank, Daniel L., Flessner, Michael L., Wallace, John M., Cahoon, Charles W.   +24 more
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Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Virginia Cooperative Extension Organizational Chart

, 2017
This document is an organizational chart of Virginia Cooperative Extension personnel.title from VCE publications page; document revised August ...
Jones, Edwin J.
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2021 Field Crops PMG

, 2021
The Virginia Pest Management Guide (PMG) series lists options for management of major pests: diseases, insects, nematodes, and weeds. These guides are produced by Virginia Cooperative Extension and each guide is revised annually.
Langston, David B., Lamb, Curt, Day, Eric R., Herbert, D. Ames Jr., VanGessel, Mark, Singh, Vijay, Currin, John F., Hines, Tommy, Taylor, Sally V., Vollmer, Kurt, Wilson, James, Balota, Maria, Lingenfelter, Dwight, Johnson, Quintin, Besancon, Thierry E., Jordan, David, McCoy, Tim, Frame, W. Hunter, Johnson, Charles S., Koehler, Alyssa, Chandra, Rakesh, Frank, Daniel L., Flessner, Michael L., Wallace, John M., Cahoon, Charles W.   +24 more
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Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Publishing cooperative and work-integrated education literature: The Asia-Pacific Journal of Cooperative Education

, 2012
The Asia-Pacific Journal of Cooperative Education (APJCE) was founded in 1999, with the first volume published in 2000. The journal strongly adhered to the philosophy of having freely and readily accessible information, and opted to be a free, fully ...
Zegwaard, Karsten E.
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2021 Field Crops PMG - Disease and Nematode Management

, 2021
This is a chapter of the 2021 Field Crops PMG. The Virginia Pest Management Guide (PMG) series lists options for management of major pests: diseases, insects, nematodes, and weeds.
Langston, David B., Koehler, Alyssa, Johnson, Charles S.   +2 more
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Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source