Results 91 to 100 of about 145,104 (305)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The Effect of Impartial Beneficence on Bystander Cooperation Behavior: The Roles of Social Perception and Impartial Beneficence Personality

Behavioral Sciences
Previous research on utilitarianism has focused predominantly on instrumental harm while neglecting the investigation of impartial beneficence. This study designed three progressive experiments (total n = 1378) to explore how impartial beneficence ...
Xiaodan Xu, Yingjun Zhang, Ming Yu, Hongju Li, Feng Zhang, Yan Xu   +5 more
doaj   +1 more source

THE PSYCHOLOGICAL CHARACTERISTICS OF GRAMMAR SKILLS AND SOME HINTS FOR ENHANCING STUDENT COOPERATIVE BEHAVIOR AND CLASSROOM MANAGEMENT

, 2022
Qayumova Dildora
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Factors affecting nurses' collaboration and communication skills with colleagues: The role of communication skills on collaboration

Adıyaman Üniversitesi Sağlık Bilimleri Dergisi
Aim: To determine the factors affecting nurses' collaboration and communication skills with colleagues and to evaluate the role of communication skills on collaboration.Materials and Methods: A descriptive cross-sectional study design was used. The study
Ali Kaplan, Selçuk Öztürk
doaj   +1 more source

Overexpression of CDT1 inhibits cell cycle progression at S phase by interacting with the mini‐chromosome maintenance complex and causes DNA damage

FEBS Open Bio, EarlyView.
CDT1 is an essential protein for DNA replication licensing that loads the MCM complex, the eukaryotic replicative DNA helicase, onto replication origins. Overexpression of CDT1 induces cell cycle arrest at the S phase. Here we showed CDT1 inhibits the progression of replication forks by interacting with the MCM complex, leading to the stalling and ...
Takashi Tsuyama, Nonoka Takayama, Rina Tanaka, Yuuki Arai, Yohko Yamaguchi, Yuko Nawata, Yutaro Azuma, Shusuke Tada   +7 more
wiley   +1 more source

Perceptions and Attitudes of First-Year Medical Students on a Modified Team-Based Learning (TBL) Strategy in Anatomy

Sultan Qaboos University Medical Journal, 2012
Objectives: Although team-based learning (TBL) is widely used in medical education, its evaluation from the perspectives of the students exposed to it has been limited.
Ibrahim M Inuwa
doaj  

The Effect of Moral Judgment on Bystander Cooperation Behavior: The Role of Personal Force

Behavioral Sciences
Background: While extensive research has examined the antecedents of utilitarian moral judgment, its subsequent social consequences remain less explored.
Xiaodan Xu, Yidie Lai, Juan Wang, Yang Liu, Ming Yu, Feng Zhang, Yan Xu   +6 more
doaj   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source