Results 41 to 50 of about 131,260 (306)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Data Dissemination in Cooperative ITS from an Information-centric Perspective

open access: yes, 2010
—The success of cooperative Intelligent Transportation Systems (ITS) applications such as collision avoidance or adaptive cruise control stands or falls with the exchange of information between distributed and usually moving nodes.
Röckl, Matthias   +3 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Comprehensive Performance Analysis of Fully Cooperative Communication in WBANs

open access: yesIEEE Access, 2016
While relay-based cooperative networks (widely known in the literature as cooperative communication), where relays only forward signals from the sources to the destination, have been extensively researched, fully cooperative systems have not been ...
L. C. Tran   +3 more
doaj   +1 more source

The integration of asynchronous and synchronous communication support in cooperative systems

open access: yes, 2022
S.180-195This paper presents the design and a first evaluation of the cooperative system KOLUMBUS 2 that integrates synchronous and asynchronous communication support and the joint work on material.
Kienle, A.
core  

Specification and Implementation of a Belief-Desire-Joint-Intention Architecture for Collaborative Problem Solving [PDF]

open access: yes, 1993
Systems composed of multiple interacting problem solvers are becoming increasingly pervasive and have been championed in some quarters as the basis of the next generation of intelligent information systems.
Jennings, N. R.   +2 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

CORELA: a cooperative relaying enhanced link adaptation algorithm for IEEE 802.11 WLANs [PDF]

open access: yes, 2011
One of the key challenges for cooperative relaying multi-rate wireless networks is the integration and interaction of relaying with link adaptation algorithms, in particular under incomplete and/or imprecise channel state information conditions.
Li, L, Kaleshi, D, Zhong, Fan
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

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