Results 91 to 100 of about 323,076 (299)

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu, Lingyao Zeng, Xulin Gan, Yilin Zhou, Han Shen, Dan Wu, Xin Shou, Minmin Jiang, Liyun Shi   +8 more
wiley   +1 more source

Finite Geometric Spaces, Steiner Systems and Cooperative Games

Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2014
Some relations between finite geometric spaces and cooperative games are considered. The games associated to Steiner systems, in particular projective and affine planes, are considered. The properties of winning and blocking coalitions are investigated.
Maturo Antonio, Maturo Fabrizio
doaj   +1 more source

Cooperative Games with Bounded Dependency Degree

, 2017
Cooperative games provide a framework to study cooperation among self-interested agents. They offer a number of solution concepts describing how the outcome of the cooperation should be shared among the players.
Elkind, Edith, Igarashi, Ayumi, Izsak, Rani   +2 more
core   +1 more source

Stochastic Cooperative Games: Theory and Applications [PDF]

, 2005
Cooperative behavior generally emerges for the individual benefit of the people and organizations involved. Whether it is an international agreement like the GATT or the local neighborhood association, the main driving force behind cooperation is the participants’ belief that it will improve their welfare.
Suijs, J.P.M., Borm, P.E.M.
openaire   +4 more sources

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Teams Games Tournament Learning Model to Improve Elementary School Students' Mathematical Creative Thinking Skills

Thinking Skills and Creativity Journal
The mathematical creative thinking skills of students are still relatively low and need to be improved. Thus, they need a learning model that can enhance their mathematical creative thinking skills.
Ni Made Puspita Udiani, Gusti Ngurah Sastra Agustika, Maria Goreti Rini Kristiantari   +2 more
doaj   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

A Gradient-Based Reinforcement Learning Algorithm for Multiple Cooperative Agents

IEEE Access, 2018
Multi-agent reinforcement learning (MARL) can be used to design intelligent agents for solving cooperative tasks. Within the MARL category, this paper proposes the probability of maximal reward based on the infinitesimal gradient ascent (PMR-IGA ...
Zhen Zhang, Dongqing Wang, Dongbin Zhao, Qiaoni Han, Tingting Song   +4 more
doaj   +1 more source