Results 201 to 210 of about 8,353 (338)

Paternal Circadian Disruption Impairs Offspring Cognition via Sperm microRNAs

Advanced Science, EarlyView.
Paternal circadian disruption remodels the sperm small RNA payload, elevating miR‐92a‐3p/miR‐25‐3p levels and perturbing early embryonic gene regulatory programs. Microinjection experiments and single‐embryo transcriptomics reveal sex‐specific developmental vulnerabilities, ultimately impairing offspring hippocampal synaptic plasticity and cognition ...
Kexin Zou, Sisi Luo, Binliang Tang, Zhiqiang Liu, Yuchuan Zhou, Yicong Meng, Zhengmu Wu, Zheng Sun, Weihui Shi, Jianzhong Sheng, Chuanjin Yu, Zhenhua Li, Siyi Wei, Mo Zhang, Yujie Luo, Jing Yan, Xueyun Qin, Jiahang Mo, Chengliang Zhou, Jinsong Li, Hefeng Huang, Yifu Ding, Guolian Ding   +22 more
wiley   +1 more source

The crayfish-rice coculture model contributes to regulating the soil fertility of rice fields and maintaining the stability of soil microbial community composition and function. [PDF]

Adv Biotechnol (Singap)
Wei D, Xing C, Zeng S, Hou D, Deng Z, Long X, Wang H, Zhou R, Yu L, Shu N, Tao Z, Zhou X, Weng S, He J, Huang Z.   +14 more
europepmc   +1 more source

PENINGKATAN HASIL BELAJAR MENULIS RESENSI BUKU DENGAN MODEL COOPERATIVE INTEGRATED READING AND COMPOSITION (CIRC)

, 2019
The ability to write a student review of SMP Negeri 244 is low. Learners do not understand the writing of reviews. The purpose of research to improve learning outcomes to write reviews.
Sumaryanto, Purwidi
core  

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Beyond the monorail perspective: constructing a dual-role engagement framework in peer feedback for second language oral communication. [PDF]

Front Psychol
He W, Jin X.
europepmc   +1 more source

MENINGKATKAN KECERDASAN LINGUISTIK PADA PEMBELAJARAN MATEMATIKA MELALUI COOPERATIVE INTEGRATED READING AND COMPOSITION (CIRC)

, 2019
Artikel ini membahas pentingnya kecerdasan bahasa (linguistik) dalam pembelajaran Matematika. Kecerdasan linguistik berkaitan dengan kemampuan membaca, menulis, berdiskusi, berargumentasi dan berdebat.
Marlina, Emas
core  

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

The use of educational psychology-based STEAM education concept in the development of English curriculum resources. [PDF]

Sci Rep
Li Y.
europepmc   +1 more source

Cross Kingdom Metabolic Engineering Paradigm Elevating Sustainable Protein Production

Advanced Science, EarlyView.
ABSTRACT Confronting the dual crisis of escalating global protein demand and unsustainable agriculture necessitates transformative solutions. Here, we pioneer evolutionary insights from maize nitrogen optimization via asparagine synthetase (ASNS) to rewire metabolism in Pichia pastoris.
Yuanyuan Du, Changyu Pi, Kai Hong, Le Gao, Xin Wu   +4 more
wiley   +1 more source

Epidemiology, Genetic Evolution, and Capsid Protein Variation of Porcine Circovirus 2 in China (2023-2024): Sustained Dominance of Genotype PCV2d. [PDF]

Viruses
Tong Z, Ni S, Liu J, Liu P, Shi D, Chen G, Zong X, Lv Y, Xiao R, Tan C.   +9 more
europepmc   +1 more source