Results 281 to 290 of about 6,828,636 (339)
Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu +8 more
wiley +1 more source
NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment
The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou +6 more
wiley +1 more source
A multimodal fusion framework integrating sequence, atomic, and fragment representations captures drug–target interactions across multiple scales. The model delivers strong predictive performance and enables efficient virtual screening. Applied to hematopoietic progenitor kinase 1 (HPK1), it identifies structurally diverse inhibitors with nanomolar ...
Shuo Liu +7 more
wiley +1 more source
Multi-Agent Reinforcement Learning with Cooperative Reward Shaping
Jincheng Zhang
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Cooperative Influence Learning
The 9th International Conference on Smart Media and Applications, 2020Cooperation or Cooperative behavior constrained between any two nodes or groups always result in constant scrutiny for reconfiguration. This continual reconfiguration creates a new modulus for expansion and thus detecting community structure can fundamentally become a problem of identifying groups and a leader in a network. In a network, the influencer
Harshit Srivastava +2 more
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