Results 1 to 10 of about 60,064 (306)
Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions. [PDF]
PLoS Genetics, 2013 p53 protects us from cancer by transcriptionally regulating tumor suppressive programs designed to either prevent the development or clonal expansion of malignant cells.
Katharina Schlereth +9 more
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Protein degradation induced by PROTAC molecules as an emerging drug discovery strategy [PDF]
Journal of the Serbian Chemical Society, 2022 The traditional concept of drug discovery is based on the occupancy driven pharmacology model. It implies the development of inhibitors occupying binding sites that directly affect protein functions.
Koravović Mladen +4 more
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Filament compliance influences cooperative activation of thin filaments and the dynamics of force production in skeletal muscle. [PDF]
PLoS Computational Biology, 2012 Striated muscle contraction is a highly cooperative process initiated by Ca²⁺ binding to the troponin complex, which leads to tropomyosin movement and myosin cross-bridge (XB) formation along thin filaments. Experimental and computational studies suggest
Bertrand C W Tanner +2 more
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Modeling the role of negative cooperativity in metabolic regulation and homeostasis. [PDF]
PLoS ONE, 2012 A significant proportion of enzymes display cooperativity in binding ligand molecules, and such effects have an important impact on metabolic regulation. This is easiest to understand in the case of positive cooperativity.
Eliot C Bush +8 more
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Allosteric activation of preformed EGF receptor dimers by a single ligand binding event
Frontiers in Endocrinology, 2022 Aberrant activation of the epidermal growth factor receptor (EGFR) by mutations has been implicated in a variety of human cancers. Elucidation of the structure of the full-length receptor is essential to understand the molecular mechanisms underlying its
Endang R. Purba +6 more
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Quantum Beam Science, 2023 We have investigated the ultrasonically induced birefringence traces of aqueous solutions of dexamethasone disodium phosphate, a derivative of hydrocortisone (cortisol).
Constantine Kouderis +1 more
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Nature Communications, 2020 Although transcription factor (TF) cooperativity is widespread, a global mechanistic understanding of the role of TF cooperativity is still lacking. Here the authors introduce a statistical learning framework that provides structural insight into TF ...
Ignacio L. Ibarra +6 more
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Physiological Role of Glutamate Dehydrogenase in Cancer Cells
Frontiers in Oncology, 2020 NH4+ increased growth rates and final densities of several human metastatic cancer cells. To assess whether glutamate dehydrogenase (GDH) in cancer cells may catalyze the reverse reaction of NH4+ fixation, its covalent regulation and kinetic parameters ...
Rafael Moreno-Sánchez +7 more
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Conditional Cooperativity in DNA Minor-Groove Recognition by Oligopeptides
Molecules, 2021 The recognition of specific DNA sequences in processes such as transcription is associated with a cooperative binding of proteins. Some transcription regulation mechanisms involve additional proteins that can influence the binding cooperativity by acting
Jurij Lah, San Hadži
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Cooperation of RNA-Binding Proteins – a Focus on Roquin Function in T Cells
Frontiers in Immunology, 2022 Post-transcriptional gene regulation by RNA-binding proteins (RBPs) is important in the prevention of inflammatory and autoimmune diseases. With respect to T cell activation and differentiation, the RBPs Roquin-1/2 and Regnase-1 play pivotal roles by ...
Gesine Behrens +2 more
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